YMR063W / RIM9

Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR063W / RIM9

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.07|P-value:4.60E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:12.00|P-value:2.07E-20 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.18|P-value:2.23E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:-5.27|P-value:3.04E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.04|P-value:9.03E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-7.44|P-value:7.29E-9 ID:SGTC_174|Compound:3553-0389|FD-Score:4.21|P-value:5.78E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:11.20|P-value:3.39E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.14|P-value:3.76E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.07|P-value:4.61E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.78|P-value:1.08E-9 ID:SGTC_264|Compound:promethazine|FD-Score:4.88|P-value:8.42E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:6.72|P-value:1.15E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:6.82|P-value:7.83E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:5.36|P-value:1.79E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:6.90|P-value:5.56E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:5.34|P-value:1.94E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.63|P-value:7.21E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:4.47|P-value:2.78E-4 ID:SGTC_393|Compound:acivicin|FD-Score:5.14|P-value:3.72E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.99|P-value:5.99E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:4.97|P-value:6.45E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.35|P-value:6.67E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.56|P-value:9.15E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:10.30|P-value:1.29E-15 ID:SGTC_511|Compound:blebbistatin|FD-Score:7.12|P-value:2.13E-8 ID:SGTC_512|Compound:prima-1|FD-Score:9.09|P-value:1.40E-12 ID:SGTC_525|Compound:k781-2675|FD-Score:9.57|P-value:9.85E-14 ID:SGTC_526|Compound:4469-0568|FD-Score:6.09|P-value:1.36E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:9.05|P-value:1.72E-12 ID:SGTC_576|Compound:1073-0113|FD-Score:4.88|P-value:8.41E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:5.14|P-value:3.69E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:4.99|P-value:5.96E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:7.75|P-value:1.29E-9 ID:SGTC_733|Compound:4069-0007|FD-Score:6.58|P-value:2.05E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:7.94|P-value:5.03E-10 ID:SGTC_773|Compound:4358-1457|FD-Score:5.18|P-value:3.28E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:5.83|P-value:3.51E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:7.54|P-value:3.36E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:7.33|P-value:8.77E-9 ID:SGTC_813|Compound:k007-0158|FD-Score:5.66|P-value:6.54E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:5.70|P-value:5.64E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:4.32|P-value:4.27E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.77|P-value:1.19E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.03|P-value:9.30E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:12.20|P-value:3.05E-21 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.19|P-value:6.07E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.02|P-value:1.75E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.01|P-value:9.72E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.17|P-value:6.47E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:9.81|P-value:2.48E-14 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:13.90|P-value:7.44E-27 ID:SGTC_1084|Compound:voriconazole|FD-Score:7.38|P-value:7.00E-9 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.84|P-value:7.06E-8 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.84|P-value:3.39E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.40|P-value:1.58E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:-4.15|P-value:8.17E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.19|P-value:3.21E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:17.30|P-value:1.41E-40 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.19|P-value:3.16E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.36|P-value:1.80E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.28|P-value:2.36E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.70|P-value:1.44E-4 ID:SGTC_1687|Compound:st020778|FD-Score:10.20|P-value:2.88E-15 ID:SGTC_1712|Compound:st032288|FD-Score:4.36|P-value:3.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.14|P-value:1.15E-6 ID:SGTC_1760|Compound:st045453|FD-Score:8.25|P-value:1.11E-10 ID:SGTC_1782|Compound:st039423|FD-Score:-5.69|P-value:7.43E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-6.51|P-value:3.63E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-16.40|P-value:3.75E-36 ID:SGTC_1788|Compound:fluconazole|FD-Score:30.90|P-value:1.96E-124 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.00|P-value:1.91E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.38|P-value:3.58E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.27|P-value:4.88E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.02|P-value:2.31E-6 ID:SGTC_1884|Compound:5633444|FD-Score:8.40|P-value:5.43E-11 ID:SGTC_1912|Compound:st060209|FD-Score:-4.83|P-value:1.23E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.25|P-value:5.23E-4 ID:SGTC_2006|Compound:4011487|FD-Score:8.34|P-value:7.09E-11 ID:SGTC_2016|Compound:5121758|FD-Score:4.85|P-value:9.19E-5 ID:SGTC_2021|Compound:4019055|FD-Score:6.07|P-value:1.47E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-6.56|P-value:2.93E-7 ID:SGTC_2183|Compound:6420625|FD-Score:5.44|P-value:1.38E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.58|P-value:9.18E-14 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.70|P-value:5.73E-6 ID:SGTC_2254|Compound:7938975|FD-Score:6.43|P-value:3.79E-7 ID:SGTC_2311|Compound:7694451|FD-Score:5.24|P-value:2.71E-5 ID:SGTC_2322|Compound:7413319|FD-Score:7.85|P-value:7.96E-10 ID:SGTC_2389|Compound:9091542|FD-Score:6.99|P-value:3.71E-8 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.80|P-value:3.98E-6 ID:SGTC_2481|Compound:5478948|FD-Score:4.20|P-value:5.87E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.68|P-value:6.15E-6 ID:SGTC_2485|Compound:5633444|FD-Score:11.70|P-value:1.62E-19 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.31|P-value:2.68E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.82|P-value:3.68E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:7.68|P-value:1.75E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.30|P-value:1.32E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.99|P-value:5.98E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.41|P-value:3.38E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.95|P-value:2.31E-6 ID:SGTC_2862|Compound:9027634|FD-Score:4.12|P-value:7.38E-4 ID:SGTC_2925|Compound:9010536|FD-Score:6.70|P-value:1.25E-7 ID:SGTC_2928|Compound:9011484|FD-Score:6.38|P-value:4.47E-7 ID:SGTC_2930|Compound:9013230|FD-Score:6.73|P-value:1.10E-7 ID:SGTC_2991|Compound:9074669|FD-Score:9.16|P-value:9.53E-13 ID:SGTC_2993|Compound:9054257|FD-Score:8.86|P-value:4.79E-12 ID:SGTC_3152|Compound:9099253|FD-Score:10.90|P-value:2.49E-17 ID:SGTC_3293|Compound:9120939|FD-Score:-4.14|P-value:8.42E-4 ID:SGTC_3296|Compound:9122258|FD-Score:4.07|P-value:8.45E-4 ID:SGTC_3308|Compound:9128332|FD-Score:6.02|P-value:1.75E-6 ID:SGTC_3310|Compound:9130229|FD-Score:4.07|P-value:8.41E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.14|P-value:8.33E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.07|P-value:4.60E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:12.00|P-value:2.07E-20 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.18|P-value:2.23E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:-5.27|P-value:3.04E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.04|P-value:9.03E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-7.44|P-value:7.29E-9 ID:SGTC_174|Compound:3553-0389|FD-Score:4.21|P-value:5.78E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:11.20|P-value:3.39E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.14|P-value:3.76E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.07|P-value:4.61E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.78|P-value:1.08E-9 ID:SGTC_264|Compound:promethazine|FD-Score:4.88|P-value:8.42E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:6.72|P-value:1.15E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:6.82|P-value:7.83E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:5.36|P-value:1.79E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:6.90|P-value:5.56E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:5.34|P-value:1.94E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.63|P-value:7.21E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:4.47|P-value:2.78E-4 ID:SGTC_393|Compound:acivicin|FD-Score:5.14|P-value:3.72E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.99|P-value:5.99E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:4.97|P-value:6.45E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.35|P-value:6.67E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.56|P-value:9.15E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:10.30|P-value:1.29E-15 ID:SGTC_511|Compound:blebbistatin|FD-Score:7.12|P-value:2.13E-8 ID:SGTC_512|Compound:prima-1|FD-Score:9.09|P-value:1.40E-12 ID:SGTC_525|Compound:k781-2675|FD-Score:9.57|P-value:9.85E-14 ID:SGTC_526|Compound:4469-0568|FD-Score:6.09|P-value:1.36E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:9.05|P-value:1.72E-12 ID:SGTC_576|Compound:1073-0113|FD-Score:4.88|P-value:8.41E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:5.14|P-value:3.69E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:4.99|P-value:5.96E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:7.75|P-value:1.29E-9 ID:SGTC_733|Compound:4069-0007|FD-Score:6.58|P-value:2.05E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:7.94|P-value:5.03E-10 ID:SGTC_773|Compound:4358-1457|FD-Score:5.18|P-value:3.28E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:5.83|P-value:3.51E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:7.54|P-value:3.36E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:7.33|P-value:8.77E-9 ID:SGTC_813|Compound:k007-0158|FD-Score:5.66|P-value:6.54E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:5.70|P-value:5.64E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:4.32|P-value:4.27E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.77|P-value:1.19E-4 ID:SGTC_917|Compound:harmaline|FD-Score:4.03|P-value:9.30E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:12.20|P-value:3.05E-21 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.19|P-value:6.07E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.02|P-value:1.75E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.01|P-value:9.72E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.17|P-value:6.47E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:9.81|P-value:2.48E-14 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:13.90|P-value:7.44E-27 ID:SGTC_1084|Compound:voriconazole|FD-Score:7.38|P-value:7.00E-9 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.84|P-value:7.06E-8 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.84|P-value:3.39E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.40|P-value:1.58E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:-4.15|P-value:8.17E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.19|P-value:3.21E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:17.30|P-value:1.41E-40 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.19|P-value:3.16E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.36|P-value:1.80E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.28|P-value:2.36E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.70|P-value:1.44E-4 ID:SGTC_1687|Compound:st020778|FD-Score:10.20|P-value:2.88E-15 ID:SGTC_1712|Compound:st032288|FD-Score:4.36|P-value:3.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.14|P-value:1.15E-6 ID:SGTC_1760|Compound:st045453|FD-Score:8.25|P-value:1.11E-10 ID:SGTC_1782|Compound:st039423|FD-Score:-5.69|P-value:7.43E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-6.51|P-value:3.63E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-16.40|P-value:3.75E-36 ID:SGTC_1788|Compound:fluconazole|FD-Score:30.90|P-value:1.96E-124 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.00|P-value:1.91E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.38|P-value:3.58E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.27|P-value:4.88E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.02|P-value:2.31E-6 ID:SGTC_1884|Compound:5633444|FD-Score:8.40|P-value:5.43E-11 ID:SGTC_1912|Compound:st060209|FD-Score:-4.83|P-value:1.23E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.25|P-value:5.23E-4 ID:SGTC_2006|Compound:4011487|FD-Score:8.34|P-value:7.09E-11 ID:SGTC_2016|Compound:5121758|FD-Score:4.85|P-value:9.19E-5 ID:SGTC_2021|Compound:4019055|FD-Score:6.07|P-value:1.47E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-6.56|P-value:2.93E-7 ID:SGTC_2183|Compound:6420625|FD-Score:5.44|P-value:1.38E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.58|P-value:9.18E-14 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.70|P-value:5.73E-6 ID:SGTC_2254|Compound:7938975|FD-Score:6.43|P-value:3.79E-7 ID:SGTC_2311|Compound:7694451|FD-Score:5.24|P-value:2.71E-5 ID:SGTC_2322|Compound:7413319|FD-Score:7.85|P-value:7.96E-10 ID:SGTC_2389|Compound:9091542|FD-Score:6.99|P-value:3.71E-8 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.80|P-value:3.98E-6 ID:SGTC_2481|Compound:5478948|FD-Score:4.20|P-value:5.87E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.68|P-value:6.15E-6 ID:SGTC_2485|Compound:5633444|FD-Score:11.70|P-value:1.62E-19 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.31|P-value:2.68E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.82|P-value:3.68E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:7.68|P-value:1.75E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.30|P-value:1.32E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.99|P-value:5.98E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.41|P-value:3.38E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.95|P-value:2.31E-6 ID:SGTC_2862|Compound:9027634|FD-Score:4.12|P-value:7.38E-4 ID:SGTC_2925|Compound:9010536|FD-Score:6.70|P-value:1.25E-7 ID:SGTC_2928|Compound:9011484|FD-Score:6.38|P-value:4.47E-7 ID:SGTC_2930|Compound:9013230|FD-Score:6.73|P-value:1.10E-7 ID:SGTC_2991|Compound:9074669|FD-Score:9.16|P-value:9.53E-13 ID:SGTC_2993|Compound:9054257|FD-Score:8.86|P-value:4.79E-12 ID:SGTC_3152|Compound:9099253|FD-Score:10.90|P-value:2.49E-17 ID:SGTC_3293|Compound:9120939|FD-Score:-4.14|P-value:8.42E-4 ID:SGTC_3296|Compound:9122258|FD-Score:4.07|P-value:8.45E-4 ID:SGTC_3308|Compound:9128332|FD-Score:6.02|P-value:1.75E-6 ID:SGTC_3310|Compound:9130229|FD-Score:4.07|P-value:8.41E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.14|P-value:8.33E-4

Top fitness defect scores for YMR063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1788 fluconazole 30.90 20.0 µM 1.96E-124 azole & statin 1 3.08E-210
2 SGTC_1317 1273-0028 17.30 910.0 nM 1.41E-40 azole & statin 4 1.65E-67
3 SGTC_1083 didemethylchlorpromazine sulfoxide 13.90 707.4 nM 7.44E-27 redox potentiating 3 3.31E-44
4 SGTC_922 1866-0035 12.20 480.0 µM 3.05E-21 excess fatty acid 5 1.09E-34
5 SGTC_43 0570-0105 12.00 72.5 µM 2.07E-20 ERG2 6 2.78E-33
6 SGTC_2485 5633444 11.70 17.8 µM 1.62E-19 redox potentiating 2 9.06E-32
7 SGTC_227 fluconazole 11.20 33.5 µM 3.39E-18 azole & statin 12 1.56E-29
8 SGTC_3152 9099253 10.90 49.5 µM 2.49E-17 NEO1-PIK1 19 4.55E-28
9 SGTC_471 1-acyl-paf 10.30 4.0 µM 1.29E-15 DNA intercalators 1 3.61E-25
10 SGTC_1687 st020778 10.20 55.4 µM 2.88E-15 47 1.40E-24
11 SGTC_1067 clotrimazole 9.81 1.4 µM 2.48E-14 azole & statin 1 5.32E-23
12 SGTC_2249 haloperidol 9.58 116.4 µM 9.18E-14 ergosterol depletion effects on membrane 17 4.86E-22
13 SGTC_525 k781-2675 9.57 26.7 µM 9.85E-14 redox potentiating 7 5.47E-22
14 SGTC_2991 9074669 9.16 71.4 µM 9.53E-13 azole & statin 7 2.52E-20
15 SGTC_512 prima-1 9.09 270.0 µM 1.40E-12 DNA intercalators 1 4.82E-20
16 SGTC_528 3492-0019 9.05 172.0 µM 1.72E-12 calcium & mitochondrial duress 51 6.86E-20
17 SGTC_2993 9054257 8.86 71.4 µM 4.79E-12 fatty acid desaturase (OLE1) 9 3.84E-19
18 SGTC_1884 5633444 8.40 25.0 µM 5.43E-11 redox potentiating 18 2.30E-17
19 SGTC_2006 4011487 8.34 200.0 µM 7.09E-11 endomembrane recycling 28 3.60E-17
20 SGTC_1760 st045453 8.25 10.4 µM 1.11E-10 NEO1-PIK1 49 7.68E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.572 4.77E-289 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.562 1.42E-277 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.540 1.70E-252 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.468 1.17E-181 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.451 6.88E-167 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.448 1.04E-164 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.430 5.13E-151 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.372 2.44E-110 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.347 2.45E-95 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.323 5.91E-82 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.317 5.40E-79 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.299 3.03E-70 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.285 1.27E-63 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.277 3.99E-60 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.269 1.81E-56 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane