YMR064W / AEP1

Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR064W / AEP1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.07|P-value:4.97E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.79|P-value:1.29E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.96|P-value:2.44E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.57|P-value:8.79E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.79|P-value:1.31E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.64|P-value:7.05E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.79|P-value:4.20E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.56|P-value:8.43E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.93|P-value:2.86E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.34|P-value:7.03E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:4.54|P-value:3.33E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.90|P-value:3.12E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.94|P-value:2.75E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.33|P-value:7.31E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.30|P-value:7.69E-72 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.41|P-value:4.98E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.60|P-value:1.01E-24 ID:SGTC_310|Compound:1273-0058|FD-Score:8.27|P-value:1.83E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:6.46|P-value:6.85E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:4.21|P-value:1.10E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.29|P-value:8.40E-5 ID:SGTC_433|Compound:pimozide|FD-Score:4.87|P-value:9.69E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.82|P-value:9.38E-10 ID:SGTC_629|Compound:3448-6466|FD-Score:3.78|P-value:4.63E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:5.11|P-value:3.67E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.66|P-value:6.20E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.48|P-value:4.22E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.95|P-value:7.09E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.57|P-value:8.67E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:8.65|P-value:1.45E-14 ID:SGTC_979|Compound:1426-2828|FD-Score:5.53|P-value:5.99E-7 ID:SGTC_992|Compound:3909-8734|FD-Score:3.96|P-value:2.58E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.60|P-value:7.55E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.94|P-value:2.71E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.06|P-value:4.46E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:5.49|P-value:7.22E-7 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.53|P-value:9.77E-4 ID:SGTC_1742|Compound:st038235|FD-Score:9.55|P-value:2.37E-17 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.55|P-value:3.28E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.09|P-value:1.55E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-3.99|P-value:2.19E-4 ID:SGTC_2033|Compound:5192550|FD-Score:5.19|P-value:2.60E-6 ID:SGTC_2077|Compound:5212015|FD-Score:5.04|P-value:4.92E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.58|P-value:8.49E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.23|P-value:9.49E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-3.67|P-value:6.09E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.17|P-value:2.88E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.44|P-value:4.48E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:7.77|P-value:4.32E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.19|P-value:2.65E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.61|P-value:7.75E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-7.74|P-value:4.73E-12 ID:SGTC_2851|Compound:9015922|FD-Score:4.19|P-value:1.18E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.86|P-value:3.51E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.79|P-value:4.20E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.74|P-value:5.10E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.90|P-value:3.13E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.08|P-value:1.72E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.80|P-value:4.31E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.53|P-value:9.77E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.76|P-value:4.92E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.60|P-value:7.87E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.07|P-value:4.97E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.79|P-value:1.29E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.96|P-value:2.44E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.57|P-value:8.79E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.79|P-value:1.31E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.64|P-value:7.05E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.79|P-value:4.20E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.56|P-value:8.43E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.93|P-value:2.86E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.34|P-value:7.03E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:4.54|P-value:3.33E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.90|P-value:3.12E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.94|P-value:2.75E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.33|P-value:7.31E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.30|P-value:7.69E-72 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.41|P-value:4.98E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.60|P-value:1.01E-24 ID:SGTC_310|Compound:1273-0058|FD-Score:8.27|P-value:1.83E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:6.46|P-value:6.85E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:4.21|P-value:1.10E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.29|P-value:8.40E-5 ID:SGTC_433|Compound:pimozide|FD-Score:4.87|P-value:9.69E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.82|P-value:9.38E-10 ID:SGTC_629|Compound:3448-6466|FD-Score:3.78|P-value:4.63E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:5.11|P-value:3.67E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.66|P-value:6.20E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.48|P-value:4.22E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.95|P-value:7.09E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.57|P-value:8.67E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:8.65|P-value:1.45E-14 ID:SGTC_979|Compound:1426-2828|FD-Score:5.53|P-value:5.99E-7 ID:SGTC_992|Compound:3909-8734|FD-Score:3.96|P-value:2.58E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.60|P-value:7.55E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.94|P-value:2.71E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.06|P-value:4.46E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:5.49|P-value:7.22E-7 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.53|P-value:9.77E-4 ID:SGTC_1742|Compound:st038235|FD-Score:9.55|P-value:2.37E-17 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.55|P-value:3.28E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.09|P-value:1.55E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-3.99|P-value:2.19E-4 ID:SGTC_2033|Compound:5192550|FD-Score:5.19|P-value:2.60E-6 ID:SGTC_2077|Compound:5212015|FD-Score:5.04|P-value:4.92E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.58|P-value:8.49E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.23|P-value:9.49E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-3.67|P-value:6.09E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.17|P-value:2.88E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.44|P-value:4.48E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:7.77|P-value:4.32E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.19|P-value:2.65E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.61|P-value:7.75E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-7.74|P-value:4.73E-12 ID:SGTC_2851|Compound:9015922|FD-Score:4.19|P-value:1.18E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.86|P-value:3.51E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.79|P-value:4.20E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.74|P-value:5.10E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.90|P-value:3.13E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.08|P-value:1.72E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.80|P-value:4.31E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.53|P-value:9.77E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.76|P-value:4.92E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.60|P-value:7.87E-4

Top fitness defect scores for YMR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.30 5.3 µM 7.69E-72 51 2.59E-92
2 SGTC_275 trichlorophene 11.60 5.7 µM 1.01E-24 mitochondrial stress 26 1.96E-31
3 SGTC_1742 st038235 9.55 28.9 µM 2.37E-17 mitochondrial stress 13 6.34E-22
4 SGTC_969 1313-0238 8.65 134.0 µM 1.45E-14 mitochondrial processes 1 2.50E-18
5 SGTC_310 1273-0058 8.27 1.1 µM 1.83E-13 mitochondrial stress 81 6.55E-17
6 SGTC_2630 antimycin a 7.77 100.0 µM 4.32E-12 mitochondrial processes 5 3.85E-15
7 SGTC_314 1671-0008 6.46 2.7 µM 6.85E-9 4 5.08E-11
8 SGTC_10 0279-0212 6.07 42.6 µM 4.97E-8 TRP & mitochondrial translation 28 6.51E-10
9 SGTC_979 1426-2828 5.53 121.0 µM 5.99E-7 4 1.59E-8
10 SGTC_1584 6-fluoro-dl-tryptophan 5.49 90.0 µM 7.22E-7 mitochondrial processes 3 2.03E-8
11 SGTC_2033 5192550 5.19 145.0 µM 2.60E-6 3 1.05E-7
12 SGTC_2688 kanamycin b 5.19 96.7 µM 2.65E-6 calcium & mitochondrial duress 228 1.07E-7
13 SGTC_2497 7-hydroxyflavone 5.17 100.0 µM 2.88E-6 5 1.20E-7
14 SGTC_715 0868-0130 5.11 184.0 µM 3.67E-6 4 1.63E-7
15 SGTC_1542 7-hydroxy-3'-methoxyflavone 5.06 49.7 µM 4.46E-6 5 2.10E-7
16 SGTC_2077 5212015 5.04 200.0 µM 4.92E-6 37 2.38E-7
17 SGTC_874 0599-0792 4.95 117.0 µM 7.09E-6 12 3.80E-7
18 SGTC_433 pimozide 4.87 108.0 µM 9.69E-6 7 5.67E-7
19 SGTC_28 pentachloropyridine N-oxide 4.79 1.6 µM 1.29E-5 TSC3-RPN4 34 8.20E-7
20 SGTC_70 0141-0289 4.79 43.3 µM 1.31E-5 mitochondrial stress 121 8.36E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.479 9.87E-192 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.463 3.48E-178 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.456 3.94E-172 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.453 1.22E-169 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.446 8.22E-164 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.439 6.05E-158 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.439 4.27E-157 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.437 1.26E-156 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.435 6.83E-155 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.429 5.38E-150 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
0.428 5.53E-150 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.427 6.13E-149 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.427 1.42E-148 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.424 2.69E-146 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.424 2.76E-146 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase