YMR066W / SOV1

Mitochondrial protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR066W / SOV1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.63|P-value:4.13E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.51|P-value:6.25E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.40|P-value:2.54E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.42|P-value:2.37E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.39|P-value:9.17E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.21|P-value:8.06E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.64|P-value:4.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.53|P-value:9.31E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.39|P-value:2.71E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.23|P-value:7.35E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:5.04|P-value:1.80E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.42|P-value:8.14E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.74|P-value:2.91E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:4.69|P-value:7.95E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.54|P-value:5.57E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.33|P-value:2.81E-9 ID:SGTC_573|Compound:3702-0553|FD-Score:3.54|P-value:5.57E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.50|P-value:1.77E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.32|P-value:3.55E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.58|P-value:1.23E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:5.75|P-value:6.15E-8 ID:SGTC_761|Compound:k216-0224|FD-Score:3.62|P-value:4.35E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-4.32|P-value:3.44E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:10.10|P-value:7.80E-21 ID:SGTC_1039|Compound:k821-0043|FD-Score:8.52|P-value:2.33E-15 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.82|P-value:4.69E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.53|P-value:5.85E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.68|P-value:3.51E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.42|P-value:8.27E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.96|P-value:1.35E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.14|P-value:6.88E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.70|P-value:3.32E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.72|P-value:6.91E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.97|P-value:1.29E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.64|P-value:4.04E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.40|P-value:8.85E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.71|P-value:3.16E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.38|P-value:3.78E-7 ID:SGTC_1627|Compound:st003713|FD-Score:3.49|P-value:6.60E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.36|P-value:3.01E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.67|P-value:8.61E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.76|P-value:2.74E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.75|P-value:2.77E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.71|P-value:3.22E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-5.61|P-value:1.21E-7 ID:SGTC_1909|Compound:st060837|FD-Score:-3.67|P-value:3.64E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.78|P-value:5.38E-8 ID:SGTC_1935|Compound:st074532|FD-Score:3.96|P-value:1.33E-4 ID:SGTC_2001|Compound:4023502|FD-Score:5.41|P-value:3.24E-7 ID:SGTC_2013|Compound:4024628|FD-Score:5.34|P-value:4.41E-7 ID:SGTC_2231|Compound:micatex|FD-Score:4.33|P-value:3.42E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.84|P-value:4.21E-6 ID:SGTC_2255|Compound:7941087|FD-Score:-3.44|P-value:7.77E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.08|P-value:8.69E-5 ID:SGTC_2288|Compound:7946289|FD-Score:4.09|P-value:8.39E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.23|P-value:4.94E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.58|P-value:4.96E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.51|P-value:6.11E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.96|P-value:1.34E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.10|P-value:7.96E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.44|P-value:7.64E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.38|P-value:9.26E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.41|P-value:8.42E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.29|P-value:5.55E-7 ID:SGTC_2933|Compound:9026794|FD-Score:3.55|P-value:5.53E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.53|P-value:5.87E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.77|P-value:2.62E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.72|P-value:7.07E-6 ID:SGTC_3191|Compound:9110352|FD-Score:-3.64|P-value:3.99E-4 ID:SGTC_3194|Compound:9111903|FD-Score:9.48|P-value:1.41E-18 ID:SGTC_3195|Compound:9113082|FD-Score:-6.28|P-value:3.80E-9 ID:SGTC_3197|Compound:9113331|FD-Score:8.13|P-value:3.63E-14 ID:SGTC_3306|Compound:9127676|FD-Score:-3.87|P-value:1.84E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.63|P-value:4.13E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.51|P-value:6.25E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.40|P-value:2.54E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.42|P-value:2.37E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.39|P-value:9.17E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.21|P-value:8.06E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.64|P-value:4.03E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.53|P-value:9.31E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.39|P-value:2.71E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.23|P-value:7.35E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:5.04|P-value:1.80E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.42|P-value:8.14E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.74|P-value:2.91E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:4.69|P-value:7.95E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.54|P-value:5.57E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.33|P-value:2.81E-9 ID:SGTC_573|Compound:3702-0553|FD-Score:3.54|P-value:5.57E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.50|P-value:1.77E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.32|P-value:3.55E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.58|P-value:1.23E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:5.75|P-value:6.15E-8 ID:SGTC_761|Compound:k216-0224|FD-Score:3.62|P-value:4.35E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-4.32|P-value:3.44E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:10.10|P-value:7.80E-21 ID:SGTC_1039|Compound:k821-0043|FD-Score:8.52|P-value:2.33E-15 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.82|P-value:4.69E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.53|P-value:5.85E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.68|P-value:3.51E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.42|P-value:8.27E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.96|P-value:1.35E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.14|P-value:6.88E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.70|P-value:3.32E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.72|P-value:6.91E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.97|P-value:1.29E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.64|P-value:4.04E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.40|P-value:8.85E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.71|P-value:3.16E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.38|P-value:3.78E-7 ID:SGTC_1627|Compound:st003713|FD-Score:3.49|P-value:6.60E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.36|P-value:3.01E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.67|P-value:8.61E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.76|P-value:2.74E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.75|P-value:2.77E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.71|P-value:3.22E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-5.61|P-value:1.21E-7 ID:SGTC_1909|Compound:st060837|FD-Score:-3.67|P-value:3.64E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.78|P-value:5.38E-8 ID:SGTC_1935|Compound:st074532|FD-Score:3.96|P-value:1.33E-4 ID:SGTC_2001|Compound:4023502|FD-Score:5.41|P-value:3.24E-7 ID:SGTC_2013|Compound:4024628|FD-Score:5.34|P-value:4.41E-7 ID:SGTC_2231|Compound:micatex|FD-Score:4.33|P-value:3.42E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.84|P-value:4.21E-6 ID:SGTC_2255|Compound:7941087|FD-Score:-3.44|P-value:7.77E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.08|P-value:8.69E-5 ID:SGTC_2288|Compound:7946289|FD-Score:4.09|P-value:8.39E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.23|P-value:4.94E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.58|P-value:4.96E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.51|P-value:6.11E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.96|P-value:1.34E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.10|P-value:7.96E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.44|P-value:7.64E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.38|P-value:9.26E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.41|P-value:8.42E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.29|P-value:5.55E-7 ID:SGTC_2933|Compound:9026794|FD-Score:3.55|P-value:5.53E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.53|P-value:5.87E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.77|P-value:2.62E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.72|P-value:7.07E-6 ID:SGTC_3191|Compound:9110352|FD-Score:-3.64|P-value:3.99E-4 ID:SGTC_3194|Compound:9111903|FD-Score:9.48|P-value:1.41E-18 ID:SGTC_3195|Compound:9113082|FD-Score:-6.28|P-value:3.80E-9 ID:SGTC_3197|Compound:9113331|FD-Score:8.13|P-value:3.63E-14 ID:SGTC_3306|Compound:9127676|FD-Score:-3.87|P-value:1.84E-4

Top fitness defect scores for YMR066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1034 k072-0165 10.10 12.7 µM 7.80E-21 Golgi 2 2.89E-24
2 SGTC_3194 9111903 9.48 49.5 µM 1.41E-18 1 1.33E-21
3 SGTC_1039 k821-0043 8.52 94.0 µM 2.33E-15 Golgi 2 8.23E-18
4 SGTC_3197 9113331 8.13 49.5 µM 3.63E-14 1 2.09E-16
5 SGTC_236 1509-0011 6.53 5.3 µM 9.31E-10 275 3.25E-11
6 SGTC_1916 st067606 5.78 49.2 µM 5.38E-8 9 3.84E-9
7 SGTC_727 3032-0951 5.75 202.0 µM 6.15E-8 9 4.49E-9
8 SGTC_2001 4023502 5.41 57.7 µM 3.24E-7 mitochondrial processes 3 3.16E-8
9 SGTC_1622 st003707 5.38 19.4 µM 3.78E-7 calcium & mitochondrial duress 13 3.80E-8
10 SGTC_2013 4024628 5.34 200.0 µM 4.41E-7 23 4.56E-8
11 SGTC_310 1273-0058 5.23 1.1 µM 7.35E-7 mitochondrial stress 175 8.30E-8
12 SGTC_173 1273-0061 5.21 2.7 µM 8.06E-7 mitochondrial stress 139 9.25E-8
13 SGTC_314 1671-0008 5.04 2.7 µM 1.80E-6 22 2.37E-7
14 SGTC_2250 alverine citrate 4.84 130.0 µM 4.21E-6 100 6.45E-7
15 SGTC_1041 0206-0046 4.82 107.0 µM 4.69E-6 21 7.31E-7
16 SGTC_1426 4048-4480 4.72 71.7 µM 6.91E-6 60S ribosome export 6 1.15E-6
17 SGTC_3186 9110464 4.72 49.5 µM 7.07E-6 RPP1 & pyrimidine depletion 5 1.18E-6
18 SGTC_333 3486-0131 4.69 40.1 µM 7.95E-6 amide catabolism 3 1.36E-6
19 SGTC_1742 st038235 4.67 28.9 µM 8.61E-6 mitochondrial stress 89 1.49E-6
20 SGTC_717 1532-0246 4.58 73.2 µM 1.23E-5 Golgi 17 2.27E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 9.09E-65 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.284 2.65E-63 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.271 2.25E-57 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.265 3.54E-55 YOR205C GEP3 hom Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)
0.264 1.50E-54 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.264 1.50E-54 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.263 2.64E-54 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.262 1.37E-53 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.260 4.32E-53 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.251 3.51E-49 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.250 6.19E-49 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.249 1.76E-48 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.248 4.55E-48 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.246 1.71E-47 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.246 1.99E-47 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation