YMR067C / UBX4

UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR067C / UBX4

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.67|P-value:8.92E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:16.50|P-value:7.66E-53 ID:SGTC_55|Compound:0767-0285|FD-Score:4.98|P-value:2.43E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:19.20|P-value:8.37E-71 ID:SGTC_67|Compound:0335-0847|FD-Score:5.34|P-value:4.58E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:10.00|P-value:1.18E-20 ID:SGTC_103|Compound:0844-0104|FD-Score:11.80|P-value:1.11E-27 ID:SGTC_107|Compound:0358-0022|FD-Score:4.14|P-value:7.26E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.97|P-value:2.52E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:6.36E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:5.54|P-value:1.76E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:8.51|P-value:2.31E-15 ID:SGTC_165|Compound:k038-0023|FD-Score:4.75|P-value:6.45E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:3.47|P-value:7.37E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:4.10|P-value:8.65E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.39|P-value:9.72E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.70|P-value:3.48E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.73|P-value:4.96E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:5.06|P-value:1.67E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.81|P-value:5.10E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:11.90|P-value:3.66E-28 ID:SGTC_367|Compound:0335-0881|FD-Score:5.21|P-value:8.35E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:8.46|P-value:3.35E-15 ID:SGTC_384|Compound:k007-0144|FD-Score:11.60|P-value:5.42E-27 ID:SGTC_426|Compound:0988-0037|FD-Score:3.99|P-value:1.28E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.34|P-value:3.41E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.88|P-value:1.89E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:-3.66|P-value:3.09E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.87|P-value:3.82E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:12.80|P-value:1.24E-32 ID:SGTC_575|Compound:k072-0246|FD-Score:4.06|P-value:9.76E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:5.56|P-value:1.62E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:5.13|P-value:1.20E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:6.48|P-value:1.22E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:6.54|P-value:9.07E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:7.10|P-value:3.14E-11 ID:SGTC_837|Compound:0091-0265|FD-Score:6.98|P-value:6.56E-11 ID:SGTC_846|Compound:0335-0850|FD-Score:6.58|P-value:7.03E-10 ID:SGTC_868|Compound:0527-0199|FD-Score:3.65|P-value:4.10E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.91|P-value:1.72E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.81|P-value:5.02E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:9.53|P-value:7.69E-19 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.17|P-value:1.02E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.41|P-value:9.17E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.33|P-value:7.57E-12 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.61|P-value:3.62E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.47|P-value:5.88E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.42|P-value:8.68E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.43|P-value:8.53E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.46|P-value:7.73E-4 ID:SGTC_1689|Compound:st020265|FD-Score:23.60|P-value:8.25E-106 ID:SGTC_1750|Compound:st081859|FD-Score:10.90|P-value:5.28E-24 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.85|P-value:2.13E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.41|P-value:9.06E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.95|P-value:1.49E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-4.52|P-value:1.22E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.37|P-value:3.09E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.20|P-value:5.78E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.50|P-value:6.74E-4 ID:SGTC_2101|Compound:5377231|FD-Score:6.51|P-value:1.05E-9 ID:SGTC_2207|Compound:7258803|FD-Score:3.83|P-value:2.26E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.07|P-value:1.60E-6 ID:SGTC_2551|Compound:apiole|FD-Score:-5.42|P-value:2.15E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.31|P-value:9.70E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.23|P-value:7.67E-7 ID:SGTC_2923|Compound:7992654|FD-Score:3.63|P-value:4.51E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.48|P-value:7.31E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.94|P-value:2.87E-6 ID:SGTC_3018|Compound:9082602|FD-Score:-5.53|P-value:1.24E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.50|P-value:6.76E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.17|P-value:6.68E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.77|P-value:6.05E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:4.67|P-value:8.92E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:16.50|P-value:7.66E-53 ID:SGTC_55|Compound:0767-0285|FD-Score:4.98|P-value:2.43E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:19.20|P-value:8.37E-71 ID:SGTC_67|Compound:0335-0847|FD-Score:5.34|P-value:4.58E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:10.00|P-value:1.18E-20 ID:SGTC_103|Compound:0844-0104|FD-Score:11.80|P-value:1.11E-27 ID:SGTC_107|Compound:0358-0022|FD-Score:4.14|P-value:7.26E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.97|P-value:2.52E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:6.36E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:5.54|P-value:1.76E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:8.51|P-value:2.31E-15 ID:SGTC_165|Compound:k038-0023|FD-Score:4.75|P-value:6.45E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:3.47|P-value:7.37E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:4.10|P-value:8.65E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.39|P-value:9.72E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.70|P-value:3.48E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.73|P-value:4.96E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:5.06|P-value:1.67E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.81|P-value:5.10E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:11.90|P-value:3.66E-28 ID:SGTC_367|Compound:0335-0881|FD-Score:5.21|P-value:8.35E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:8.46|P-value:3.35E-15 ID:SGTC_384|Compound:k007-0144|FD-Score:11.60|P-value:5.42E-27 ID:SGTC_426|Compound:0988-0037|FD-Score:3.99|P-value:1.28E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.34|P-value:3.41E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.88|P-value:1.89E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:-3.66|P-value:3.09E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.87|P-value:3.82E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:12.80|P-value:1.24E-32 ID:SGTC_575|Compound:k072-0246|FD-Score:4.06|P-value:9.76E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:5.56|P-value:1.62E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:5.13|P-value:1.20E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:6.48|P-value:1.22E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:6.54|P-value:9.07E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:7.10|P-value:3.14E-11 ID:SGTC_837|Compound:0091-0265|FD-Score:6.98|P-value:6.56E-11 ID:SGTC_846|Compound:0335-0850|FD-Score:6.58|P-value:7.03E-10 ID:SGTC_868|Compound:0527-0199|FD-Score:3.65|P-value:4.10E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.91|P-value:1.72E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.81|P-value:5.02E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:9.53|P-value:7.69E-19 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.17|P-value:1.02E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.41|P-value:9.17E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.33|P-value:7.57E-12 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.61|P-value:3.62E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.47|P-value:5.88E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.42|P-value:8.68E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.43|P-value:8.53E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.46|P-value:7.73E-4 ID:SGTC_1689|Compound:st020265|FD-Score:23.60|P-value:8.25E-106 ID:SGTC_1750|Compound:st081859|FD-Score:10.90|P-value:5.28E-24 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.85|P-value:2.13E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.41|P-value:9.06E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.95|P-value:1.49E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-4.52|P-value:1.22E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.37|P-value:3.09E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.20|P-value:5.78E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.50|P-value:6.74E-4 ID:SGTC_2101|Compound:5377231|FD-Score:6.51|P-value:1.05E-9 ID:SGTC_2207|Compound:7258803|FD-Score:3.83|P-value:2.26E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.07|P-value:1.60E-6 ID:SGTC_2551|Compound:apiole|FD-Score:-5.42|P-value:2.15E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.31|P-value:9.70E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.23|P-value:7.67E-7 ID:SGTC_2923|Compound:7992654|FD-Score:3.63|P-value:4.51E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.48|P-value:7.31E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.94|P-value:2.87E-6 ID:SGTC_3018|Compound:9082602|FD-Score:-5.53|P-value:1.24E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.50|P-value:6.76E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.17|P-value:6.68E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.77|P-value:6.05E-6

Top fitness defect scores for YMR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1689 st020265 23.60 53.5 µM 8.25E-106 1 1.59E-123
2 SGTC_64 000l-0018 19.20 272.1 µM 8.37E-71 ubiquinone biosynthesis & proteasome 13 1.32E-82
3 SGTC_36 0335-0881 16.50 14.2 µM 7.66E-53 ubiquinone biosynthesis & proteasome 10 1.32E-61
4 SGTC_568 1193-0097 12.80 7.5 µM 1.24E-32 ERAD & cell cycle 10 5.64E-38
5 SGTC_352 k048-0007 11.90 5.1 µM 3.66E-28 ERAD & cell cycle 5 9.54E-33
6 SGTC_103 0844-0104 11.80 51.8 µM 1.11E-27 ERAD & cell cycle 18 3.49E-32
7 SGTC_384 k007-0144 11.60 5.2 µM 5.42E-27 ERAD & cell cycle 8 2.23E-31
8 SGTC_1750 st081859 10.90 2.4 µM 5.28E-24 endomembrane recycling 38 7.01E-28
9 SGTC_86 0417-1630 10.00 471.9 µM 1.18E-20 ubiquinone biosynthesis & proteasome 38 5.77E-24
10 SGTC_984 1492-0255 9.53 2.9 µM 7.69E-19 SWF1 & branched chain AA biosynthesis 4 7.68E-22
11 SGTC_158 k038-0087 8.51 26.4 µM 2.31E-15 ubiquinone biosynthesis & proteasome 43 8.97E-18
12 SGTC_373 0844-0104 8.46 25.9 µM 3.35E-15 ERAD & cell cycle 12 1.39E-17
13 SGTC_1161 k007-0610 7.33 110.0 µM 7.57E-12 ERAD & cell cycle 35 1.17E-13
14 SGTC_805 3852-0218 7.10 479.0 µM 3.14E-11 ERAD & cell cycle 16 6.17E-13
15 SGTC_837 0091-0265 6.98 12.5 µM 6.56E-11 ubiquinone biosynthesis & proteasome 9 1.46E-12
16 SGTC_846 0335-0850 6.58 148.0 µM 7.03E-10 ubiquinone biosynthesis & proteasome 12 2.34E-11
17 SGTC_794 k038-0031 6.54 316.0 µM 9.07E-10 ubiquinone biosynthesis & proteasome 46 3.15E-11
18 SGTC_2101 5377231 6.51 179.2 µM 1.05E-9 1 3.73E-11
19 SGTC_642 0335-0876 6.48 158.0 µM 1.22E-9 ubiquinone biosynthesis & proteasome 11 4.45E-11
20 SGTC_635 k038-0028 5.56 24.7 µM 1.62E-7 ubiquinone biosynthesis & proteasome 20 1.36E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.545 5.61E-259 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.455 5.29E-171 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.450 3.20E-167 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.430 6.16E-151 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.411 5.93E-137 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.406 3.74E-133 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.395 8.91E-126 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.389 1.33E-121 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.387 7.18E-120 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.384 7.26E-118 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.383 1.42E-117 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.373 2.32E-111 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.371 4.22E-110 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.371 5.93E-110 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.363 2.44E-105 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels