YMR069W / NAT4

N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR069W / NAT4

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.34|P-value:9.66E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.52|P-value:5.49E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.82|P-value:1.96E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.22|P-value:4.30E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.33|P-value:9.97E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.75|P-value:2.49E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.48|P-value:6.27E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.42|P-value:1.97E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.03|P-value:9.01E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.76|P-value:2.40E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.68|P-value:3.16E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.64|P-value:3.63E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:5.45|P-value:1.95E-7 ID:SGTC_1741|Compound:st038134|FD-Score:4.70|P-value:6.11E-6 ID:SGTC_1854|Compound:st056233|FD-Score:-3.31|P-value:9.09E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.53|P-value:5.16E-4 ID:SGTC_1968|Compound:st069590|FD-Score:4.22|P-value:4.44E-5 ID:SGTC_1972|Compound:st070201|FD-Score:-3.91|P-value:1.16E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.38|P-value:7.26E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.46|P-value:6.59E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.27|P-value:3.55E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.38|P-value:7.32E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.35|P-value:7.93E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.47|P-value:6.29E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.36|P-value:9.05E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.22|P-value:3.59E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.93|P-value:1.83E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.22|P-value:5.90E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.24|P-value:4.01E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.42|P-value:6.47E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.36|P-value:7.69E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-4.29|P-value:2.78E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.34|P-value:9.66E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.52|P-value:5.49E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.82|P-value:1.96E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.22|P-value:4.30E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.33|P-value:9.97E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.75|P-value:2.49E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.48|P-value:6.27E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.42|P-value:1.97E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.03|P-value:9.01E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.76|P-value:2.40E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.68|P-value:3.16E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.64|P-value:3.63E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:5.45|P-value:1.95E-7 ID:SGTC_1741|Compound:st038134|FD-Score:4.70|P-value:6.11E-6 ID:SGTC_1854|Compound:st056233|FD-Score:-3.31|P-value:9.09E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.53|P-value:5.16E-4 ID:SGTC_1968|Compound:st069590|FD-Score:4.22|P-value:4.44E-5 ID:SGTC_1972|Compound:st070201|FD-Score:-3.91|P-value:1.16E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.38|P-value:7.26E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.46|P-value:6.59E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.27|P-value:3.55E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.38|P-value:7.32E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.35|P-value:7.93E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.47|P-value:6.29E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.36|P-value:9.05E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.22|P-value:3.59E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.93|P-value:1.83E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.22|P-value:5.90E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.24|P-value:4.01E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.42|P-value:6.47E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.36|P-value:7.69E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-4.29|P-value:2.78E-5

Top fitness defect scores for YMR069W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1401 3807-4679 5.45 7.6 µM 1.95E-7 tubulin folding & SWR complex 7 2.51E-8
2 SGTC_2589 lobaric acid 5.22 100.0 µM 5.90E-7 10 8.91E-8
3 SGTC_1741 st038134 4.70 10.2 µM 6.11E-6 14 1.29E-6
4 SGTC_1192 1488-0095 4.42 21.4 µM 1.97E-5 9 4.90E-6
5 SGTC_2105 5350118 4.27 200.0 µM 3.55E-5 20 9.61E-6
6 SGTC_2612 dictamnine 4.24 15.5 µM 4.01E-5 RNA pol III & RNase P/MRP 38 1.11E-5
7 SGTC_315 k915-0449 4.22 187.0 µM 4.30E-5 50 1.20E-5
8 SGTC_1968 st069590 4.22 43.6 µM 4.44E-5 11 1.24E-5
9 SGTC_1203 3992-3522 4.03 103.0 µM 9.01E-5 26 2.79E-5
10 SGTC_218 alverine citrate 3.82 93.8 µM 1.96E-4 fatty acid desaturase (OLE1) 35 6.78E-5
11 SGTC_1213 1315-0166 3.76 115.0 µM 2.40E-4 34 8.55E-5
12 SGTC_721 1187-1332 3.75 279.0 µM 2.49E-4 cell wall signaling 21 8.92E-5
13 SGTC_2950 9072895 3.72 21.5 µM 2.70E-4 49 9.77E-5
14 SGTC_1358 1509-0022 3.68 2.5 µM 3.16E-4 17 1.17E-4
15 SGTC_1381 2324-0066 3.64 62.1 µM 3.63E-4 39 1.37E-4
16 SGTC_1962 st076595 3.53 64.5 µM 5.16E-4 redox potentiating 44 2.04E-4
17 SGTC_62 0180-0423 3.52 3.2 µM 5.49E-4 60S ribosome export 34 2.20E-4
18 SGTC_949 1165-0505 3.48 146.0 µM 6.27E-4 32 2.55E-4
19 SGTC_2427 5545055 3.47 42.8 µM 6.29E-4 32 2.56E-4
20 SGTC_2095 5432005 3.46 200.0 µM 6.59E-4 27 2.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.43E-17 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.140 5.03E-16 YDL087C LUC7 het Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
0.139 6.92E-16 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.113 6.44E-11 YBR162W-A YSY6 hom Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.108 4.31E-10 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.107 4.81E-10 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.083 1.42E-6 YLR425W TUS1 hom Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
0.080 3.54E-6 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.079 4.50E-6 YKL055C OAR1 hom Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
0.078 6.53E-6 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.075 1.40E-5 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.075 1.41E-5 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.074 1.85E-5 YPL248C GAL4 hom DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
0.074 1.99E-5 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.072 2.80E-5 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data