YMR071C / TVP18

Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR071C / TVP18

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:4.52|P-value:5.18E-5 ID:SGTC_57|Compound:miconazole|FD-Score:14.40|P-value:1.52E-35 ID:SGTC_58|Compound:0957-0393|FD-Score:-10.10|P-value:1.62E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:5.76|P-value:3.67E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:7.94|P-value:4.49E-12 ID:SGTC_197|Compound:4544-0043|FD-Score:3.84|P-value:4.79E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:18.50|P-value:2.18E-57 ID:SGTC_207|Compound:4185-0010|FD-Score:12.50|P-value:4.95E-27 ID:SGTC_208|Compound:k072-0098|FD-Score:6.50|P-value:1.18E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.72|P-value:4.39E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.36|P-value:2.29E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.41|P-value:3.18E-16 ID:SGTC_252|Compound:miconazole|FD-Score:8.74|P-value:3.09E-14 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.93|P-value:3.61E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.70|P-value:1.82E-11 ID:SGTC_278|Compound:4092-0821|FD-Score:8.96|P-value:7.04E-15 ID:SGTC_308|Compound:4092-1169|FD-Score:6.74|P-value:3.60E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.09|P-value:9.00E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:6.52|P-value:1.08E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:5.54|P-value:9.76E-7 ID:SGTC_346|Compound:4513-0042|FD-Score:6.17|P-value:5.71E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:3.71|P-value:7.05E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.20|P-value:5.01E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.99|P-value:9.40E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:9.22|P-value:1.23E-15 ID:SGTC_568|Compound:1193-0097|FD-Score:5.49|P-value:1.21E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:5.94|P-value:1.66E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:6.88|P-value:1.70E-9 ID:SGTC_649|Compound:1123-0311|FD-Score:4.50|P-value:5.61E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.81|P-value:5.26E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.70|P-value:2.71E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:7.42|P-value:9.19E-11 ID:SGTC_768|Compound:0384-0033|FD-Score:5.89|P-value:2.12E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:7.58|P-value:3.76E-11 ID:SGTC_811|Compound:0416-0114|FD-Score:4.08|P-value:2.24E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.21|P-value:1.48E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.44|P-value:6.88E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.17|P-value:3.63E-10 ID:SGTC_1072|Compound:oxiconazole|FD-Score:9.30|P-value:6.78E-16 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.66|P-value:8.33E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.52|P-value:5.22E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.15|P-value:1.82E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.67|P-value:2.95E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.06|P-value:6.94E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.30|P-value:1.08E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.12|P-value:1.96E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.19|P-value:1.60E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.98|P-value:3.19E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.87|P-value:4.41E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.22|P-value:1.43E-4 ID:SGTC_1750|Compound:st081859|FD-Score:12.70|P-value:3.84E-28 ID:SGTC_1754|Compound:st042065|FD-Score:3.99|P-value:2.98E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.89|P-value:1.30E-5 ID:SGTC_1797|Compound:st048695|FD-Score:6.30|P-value:3.18E-8 ID:SGTC_1800|Compound:st050079|FD-Score:4.91|P-value:1.25E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.49|P-value:5.72E-5 ID:SGTC_1803|Compound:st050068|FD-Score:7.42|P-value:9.24E-11 ID:SGTC_1949|Compound:st076024|FD-Score:3.61|P-value:9.64E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.78|P-value:5.73E-4 ID:SGTC_2006|Compound:4011487|FD-Score:9.13|P-value:2.22E-15 ID:SGTC_2021|Compound:4019055|FD-Score:4.68|P-value:2.91E-5 ID:SGTC_2036|Compound:5160441|FD-Score:8.81|P-value:1.91E-14 ID:SGTC_2050|Compound:5263056|FD-Score:3.70|P-value:7.26E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.78|P-value:5.75E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.69|P-value:7.59E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:11.10|P-value:8.06E-22 ID:SGTC_2257|Compound:7960413|FD-Score:4.66|P-value:3.09E-5 ID:SGTC_2312|Compound:7706453|FD-Score:5.01|P-value:8.27E-6 ID:SGTC_2313|Compound:7726885|FD-Score:3.76|P-value:6.07E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.06|P-value:6.54E-10 ID:SGTC_2457|Compound:5731572|FD-Score:9.33|P-value:5.67E-16 ID:SGTC_2466|Compound:5983409|FD-Score:-3.89|P-value:4.25E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.81|P-value:1.80E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.69|P-value:7.51E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.76|P-value:6.43E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.73|P-value:2.46E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.34|P-value:9.50E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.45|P-value:6.52E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.06|P-value:2.42E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.93|P-value:1.30E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:11.40|P-value:8.57E-23 ID:SGTC_2790|Compound:5423970|FD-Score:3.64|P-value:8.86E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.99|P-value:1.36E-7 ID:SGTC_2816|Compound:7982706|FD-Score:4.95|P-value:1.04E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.93|P-value:3.60E-4 ID:SGTC_2838|Compound:9002687|FD-Score:5.20|P-value:3.90E-6 ID:SGTC_2948|Compound:9070189|FD-Score:10.80|P-value:6.02E-21 ID:SGTC_2974|Compound:9094440|FD-Score:4.81|P-value:1.78E-5 ID:SGTC_2993|Compound:9054257|FD-Score:6.15|P-value:6.30E-8 ID:SGTC_3018|Compound:9082602|FD-Score:13.60|P-value:7.33E-32 ID:SGTC_3078|Compound:9116413|FD-Score:3.83|P-value:4.97E-4 ID:SGTC_3142|Compound:9086498|FD-Score:6.22|P-value:4.62E-8 ID:SGTC_3152|Compound:9099253|FD-Score:17.70|P-value:1.15E-52 ID:SGTC_3159|Compound:9100096|FD-Score:-5.52|P-value:1.11E-6 ID:SGTC_3185|Compound:9108267|FD-Score:3.91|P-value:3.84E-4 ID:SGTC_3208|Compound:9114115|FD-Score:5.79|P-value:3.21E-7 ID:SGTC_3214|Compound:9129694|FD-Score:4.02|P-value:2.72E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.63|P-value:9.11E-4 ID:SGTC_3308|Compound:9128332|FD-Score:12.40|P-value:9.35E-27 ID:SGTC_55|Compound:0767-0285|FD-Score:4.52|P-value:5.18E-5 ID:SGTC_57|Compound:miconazole|FD-Score:14.40|P-value:1.52E-35 ID:SGTC_58|Compound:0957-0393|FD-Score:-10.10|P-value:1.62E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:5.76|P-value:3.67E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:7.94|P-value:4.49E-12 ID:SGTC_197|Compound:4544-0043|FD-Score:3.84|P-value:4.79E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:18.50|P-value:2.18E-57 ID:SGTC_207|Compound:4185-0010|FD-Score:12.50|P-value:4.95E-27 ID:SGTC_208|Compound:k072-0098|FD-Score:6.50|P-value:1.18E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.72|P-value:4.39E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.36|P-value:2.29E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.41|P-value:3.18E-16 ID:SGTC_252|Compound:miconazole|FD-Score:8.74|P-value:3.09E-14 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.93|P-value:3.61E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.70|P-value:1.82E-11 ID:SGTC_278|Compound:4092-0821|FD-Score:8.96|P-value:7.04E-15 ID:SGTC_308|Compound:4092-1169|FD-Score:6.74|P-value:3.60E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.09|P-value:9.00E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:6.52|P-value:1.08E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:5.54|P-value:9.76E-7 ID:SGTC_346|Compound:4513-0042|FD-Score:6.17|P-value:5.71E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:3.71|P-value:7.05E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.20|P-value:5.01E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.99|P-value:9.40E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:9.22|P-value:1.23E-15 ID:SGTC_568|Compound:1193-0097|FD-Score:5.49|P-value:1.21E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:5.94|P-value:1.66E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:6.88|P-value:1.70E-9 ID:SGTC_649|Compound:1123-0311|FD-Score:4.50|P-value:5.61E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.81|P-value:5.26E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.70|P-value:2.71E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:7.42|P-value:9.19E-11 ID:SGTC_768|Compound:0384-0033|FD-Score:5.89|P-value:2.12E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:7.58|P-value:3.76E-11 ID:SGTC_811|Compound:0416-0114|FD-Score:4.08|P-value:2.24E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.21|P-value:1.48E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.44|P-value:6.88E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.17|P-value:3.63E-10 ID:SGTC_1072|Compound:oxiconazole|FD-Score:9.30|P-value:6.78E-16 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.66|P-value:8.33E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.52|P-value:5.22E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.15|P-value:1.82E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.67|P-value:2.95E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.06|P-value:6.94E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.30|P-value:1.08E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.12|P-value:1.96E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.19|P-value:1.60E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.98|P-value:3.19E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.87|P-value:4.41E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.22|P-value:1.43E-4 ID:SGTC_1750|Compound:st081859|FD-Score:12.70|P-value:3.84E-28 ID:SGTC_1754|Compound:st042065|FD-Score:3.99|P-value:2.98E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.89|P-value:1.30E-5 ID:SGTC_1797|Compound:st048695|FD-Score:6.30|P-value:3.18E-8 ID:SGTC_1800|Compound:st050079|FD-Score:4.91|P-value:1.25E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.49|P-value:5.72E-5 ID:SGTC_1803|Compound:st050068|FD-Score:7.42|P-value:9.24E-11 ID:SGTC_1949|Compound:st076024|FD-Score:3.61|P-value:9.64E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.78|P-value:5.73E-4 ID:SGTC_2006|Compound:4011487|FD-Score:9.13|P-value:2.22E-15 ID:SGTC_2021|Compound:4019055|FD-Score:4.68|P-value:2.91E-5 ID:SGTC_2036|Compound:5160441|FD-Score:8.81|P-value:1.91E-14 ID:SGTC_2050|Compound:5263056|FD-Score:3.70|P-value:7.26E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.78|P-value:5.75E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.69|P-value:7.59E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:11.10|P-value:8.06E-22 ID:SGTC_2257|Compound:7960413|FD-Score:4.66|P-value:3.09E-5 ID:SGTC_2312|Compound:7706453|FD-Score:5.01|P-value:8.27E-6 ID:SGTC_2313|Compound:7726885|FD-Score:3.76|P-value:6.07E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.06|P-value:6.54E-10 ID:SGTC_2457|Compound:5731572|FD-Score:9.33|P-value:5.67E-16 ID:SGTC_2466|Compound:5983409|FD-Score:-3.89|P-value:4.25E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.81|P-value:1.80E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.69|P-value:7.51E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.76|P-value:6.43E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.73|P-value:2.46E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.34|P-value:9.50E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.45|P-value:6.52E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.06|P-value:2.42E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.93|P-value:1.30E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:11.40|P-value:8.57E-23 ID:SGTC_2790|Compound:5423970|FD-Score:3.64|P-value:8.86E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.99|P-value:1.36E-7 ID:SGTC_2816|Compound:7982706|FD-Score:4.95|P-value:1.04E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.93|P-value:3.60E-4 ID:SGTC_2838|Compound:9002687|FD-Score:5.20|P-value:3.90E-6 ID:SGTC_2948|Compound:9070189|FD-Score:10.80|P-value:6.02E-21 ID:SGTC_2974|Compound:9094440|FD-Score:4.81|P-value:1.78E-5 ID:SGTC_2993|Compound:9054257|FD-Score:6.15|P-value:6.30E-8 ID:SGTC_3018|Compound:9082602|FD-Score:13.60|P-value:7.33E-32 ID:SGTC_3078|Compound:9116413|FD-Score:3.83|P-value:4.97E-4 ID:SGTC_3142|Compound:9086498|FD-Score:6.22|P-value:4.62E-8 ID:SGTC_3152|Compound:9099253|FD-Score:17.70|P-value:1.15E-52 ID:SGTC_3159|Compound:9100096|FD-Score:-5.52|P-value:1.11E-6 ID:SGTC_3185|Compound:9108267|FD-Score:3.91|P-value:3.84E-4 ID:SGTC_3208|Compound:9114115|FD-Score:5.79|P-value:3.21E-7 ID:SGTC_3214|Compound:9129694|FD-Score:4.02|P-value:2.72E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.63|P-value:9.11E-4 ID:SGTC_3308|Compound:9128332|FD-Score:12.40|P-value:9.35E-27

Top fitness defect scores for YMR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_201 4262-0159 18.50 12.8 µM 2.18E-57 ergosterol depletion effects on membrane 1 4.37E-77
2 SGTC_3152 9099253 17.70 49.5 µM 1.15E-52 NEO1-PIK1 3 1.10E-70
3 SGTC_57 miconazole 14.40 162.5 nM 1.52E-35 ergosterol depletion effects on membrane 2 1.75E-47
4 SGTC_3018 9082602 13.60 49.5 µM 7.33E-32 6 1.70E-42
5 SGTC_1750 st081859 12.70 2.4 µM 3.84E-28 endomembrane recycling 29 1.85E-37
6 SGTC_207 4185-0010 12.50 4.5 µM 4.95E-27 endomembrane recycling 11 5.88E-36
7 SGTC_3308 9128332 12.40 17.6 µM 9.35E-27 plasma membrane duress 15 1.39E-35
8 SGTC_2778 tioconazole 11.40 65.1 nM 8.57E-23 ergosterol depletion effects on membrane 11 3.21E-30
9 SGTC_2249 haloperidol 11.10 116.4 µM 8.06E-22 ergosterol depletion effects on membrane 9 6.66E-29
10 SGTC_2948 9070189 10.80 9.4 µM 6.02E-21 plasma membrane duress 9 1.01E-27
11 SGTC_221 trifluoperazine 9.41 10.3 µM 3.18E-16 NEO1-PIK1 67 2.45E-21
12 SGTC_2457 5731572 9.33 11.7 µM 5.67E-16 1 5.36E-21
13 SGTC_1072 oxiconazole 9.30 14.9 nM 6.78E-16 ergosterol depletion effects on membrane 10 6.83E-21
14 SGTC_515 4092-1064 9.22 102.0 µM 1.23E-15 plasma membrane duress 12 1.53E-20
15 SGTC_2006 4011487 9.13 200.0 µM 2.22E-15 endomembrane recycling 22 3.40E-20
16 SGTC_278 4092-0821 8.96 23.9 µM 7.04E-15 plasma membrane duress 7 1.61E-19
17 SGTC_2036 5160441 8.81 105.0 µM 1.91E-14 NEO1 21 6.21E-19
18 SGTC_252 miconazole 8.74 1.3 nM 3.09E-14 ergosterol depletion effects on membrane 5 1.19E-18
19 SGTC_178 4092-0806 7.94 87.5 µM 4.49E-12 ergosterol depletion effects on membrane 20 9.88E-16
20 SGTC_262 fenpropimorph 7.70 62.5 µM 1.82E-11 ergosterol depletion effects on membrane 7 6.55E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.607 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.498 2.17E-209 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.482 4.08E-194 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.471 6.66E-185 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.467 3.46E-181 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.446 3.32E-163 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.443 7.11E-161 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.442 5.69E-160 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.425 6.00E-147 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.406 5.60E-133 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.402 3.77E-130 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.400 2.49E-129 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.384 4.52E-118 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.362 1.54E-104 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.348 5.20E-96 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic