YMR073C / IRC21

Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR073C / IRC21

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.44|P-value:4.53E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:8.43|P-value:2.54E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:5.85|P-value:8.25E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.65|P-value:2.57E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.17|P-value:9.16E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.60|P-value:1.86E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.76|P-value:1.91E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.98|P-value:8.94E-14 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.85|P-value:8.26E-6 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:6.06|P-value:4.00E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.89|P-value:7.34E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.43|P-value:4.63E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:5.46|P-value:2.93E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.62|P-value:3.47E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.38|P-value:6.49E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.60|P-value:4.44E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.43|P-value:5.62E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.55|P-value:4.17E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.00|P-value:4.91E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:5.39|P-value:3.63E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:6.15|P-value:2.96E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.36|P-value:6.87E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:7.59|P-value:1.09E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.58|P-value:2.03E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.71|P-value:2.69E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:5.88|P-value:7.55E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:-4.91|P-value:1.25E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.95|P-value:1.36E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:8.61|P-value:1.06E-10 ID:SGTC_969|Compound:1313-0238|FD-Score:5.19|P-value:6.77E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:4.67|P-value:3.03E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.46|P-value:4.27E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.78|P-value:1.79E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.58|P-value:3.82E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.35|P-value:4.14E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.21|P-value:9.83E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.93|P-value:1.16E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:5.39|P-value:3.71E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.76|P-value:2.30E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.60|P-value:1.89E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:5.25|P-value:5.57E-5 ID:SGTC_1567|Compound:st069303|FD-Score:5.42|P-value:3.29E-5 ID:SGTC_1619|Compound:st003326|FD-Score:4.30|P-value:7.95E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.61|P-value:3.53E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.27|P-value:8.64E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.28|P-value:8.37E-4 ID:SGTC_1746|Compound:st038117|FD-Score:9.14|P-value:7.65E-12 ID:SGTC_1750|Compound:st081859|FD-Score:16.00|P-value:1.33E-32 ID:SGTC_1844|Compound:rapamycin|FD-Score:-10.90|P-value:2.83E-16 ID:SGTC_1856|Compound:st057054|FD-Score:5.06|P-value:1.00E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.19|P-value:8.77E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.26|P-value:5.39E-5 ID:SGTC_2037|Compound:5169046|FD-Score:-4.60|P-value:2.94E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.62|P-value:3.46E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.44|P-value:5.51E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-4.36|P-value:5.66E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.30|P-value:4.80E-5 ID:SGTC_2259|Compound:7964009|FD-Score:6.00|P-value:5.04E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.49|P-value:4.78E-4 ID:SGTC_2429|Compound:5902844|FD-Score:5.97|P-value:5.61E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.38|P-value:6.47E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:9.29|P-value:3.59E-12 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.96|P-value:1.06E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.54|P-value:2.30E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.29|P-value:4.76E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.70|P-value:1.39E-15 ID:SGTC_2671|Compound:danthron|FD-Score:5.14|P-value:7.87E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-8.14|P-value:7.03E-10 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.40|P-value:2.50E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:7.95|P-value:2.26E-9 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.98|P-value:1.24E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.23|P-value:7.82E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.15|P-value:7.58E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.48|P-value:5.02E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.59|P-value:3.70E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.35|P-value:6.92E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.80|P-value:1.72E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-7.81|P-value:3.09E-9 ID:SGTC_2933|Compound:9026794|FD-Score:-5.94|P-value:4.76E-6 ID:SGTC_2934|Compound:9036370|FD-Score:7.73|P-value:5.88E-9 ID:SGTC_2938|Compound:9059746|FD-Score:-4.17|P-value:9.05E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.26|P-value:7.29E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-4.28|P-value:6.93E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.61|P-value:5.50E-7 ID:SGTC_3204|Compound:9114183|FD-Score:4.28|P-value:8.29E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.50|P-value:4.74E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.56|P-value:2.14E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.44|P-value:4.53E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:8.43|P-value:2.54E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:5.85|P-value:8.25E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.65|P-value:2.57E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.17|P-value:9.16E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.60|P-value:1.86E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.76|P-value:1.91E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.98|P-value:8.94E-14 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.85|P-value:8.26E-6 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:6.06|P-value:4.00E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.89|P-value:7.34E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.43|P-value:4.63E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:5.46|P-value:2.93E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.62|P-value:3.47E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.38|P-value:6.49E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.60|P-value:4.44E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.43|P-value:5.62E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.55|P-value:4.17E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.00|P-value:4.91E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:5.39|P-value:3.63E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:6.15|P-value:2.96E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.36|P-value:6.87E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:7.59|P-value:1.09E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.58|P-value:2.03E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.71|P-value:2.69E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:5.88|P-value:7.55E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:-4.91|P-value:1.25E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:4.95|P-value:1.36E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:8.61|P-value:1.06E-10 ID:SGTC_969|Compound:1313-0238|FD-Score:5.19|P-value:6.77E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:4.67|P-value:3.03E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.46|P-value:4.27E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.78|P-value:1.79E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.58|P-value:3.82E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.35|P-value:4.14E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.21|P-value:9.83E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.93|P-value:1.16E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:5.39|P-value:3.71E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.76|P-value:2.30E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.60|P-value:1.89E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:5.25|P-value:5.57E-5 ID:SGTC_1567|Compound:st069303|FD-Score:5.42|P-value:3.29E-5 ID:SGTC_1619|Compound:st003326|FD-Score:4.30|P-value:7.95E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.61|P-value:3.53E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.27|P-value:8.64E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.28|P-value:8.37E-4 ID:SGTC_1746|Compound:st038117|FD-Score:9.14|P-value:7.65E-12 ID:SGTC_1750|Compound:st081859|FD-Score:16.00|P-value:1.33E-32 ID:SGTC_1844|Compound:rapamycin|FD-Score:-10.90|P-value:2.83E-16 ID:SGTC_1856|Compound:st057054|FD-Score:5.06|P-value:1.00E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-4.19|P-value:8.77E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.26|P-value:5.39E-5 ID:SGTC_2037|Compound:5169046|FD-Score:-4.60|P-value:2.94E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.62|P-value:3.46E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.44|P-value:5.51E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-4.36|P-value:5.66E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.30|P-value:4.80E-5 ID:SGTC_2259|Compound:7964009|FD-Score:6.00|P-value:5.04E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.49|P-value:4.78E-4 ID:SGTC_2429|Compound:5902844|FD-Score:5.97|P-value:5.61E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.38|P-value:6.47E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:9.29|P-value:3.59E-12 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.96|P-value:1.06E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.54|P-value:2.30E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.29|P-value:4.76E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.70|P-value:1.39E-15 ID:SGTC_2671|Compound:danthron|FD-Score:5.14|P-value:7.87E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-8.14|P-value:7.03E-10 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.40|P-value:2.50E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:7.95|P-value:2.26E-9 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.98|P-value:1.24E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.23|P-value:7.82E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.15|P-value:7.58E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.48|P-value:5.02E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.59|P-value:3.70E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.35|P-value:6.92E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.80|P-value:1.72E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-7.81|P-value:3.09E-9 ID:SGTC_2933|Compound:9026794|FD-Score:-5.94|P-value:4.76E-6 ID:SGTC_2934|Compound:9036370|FD-Score:7.73|P-value:5.88E-9 ID:SGTC_2938|Compound:9059746|FD-Score:-4.17|P-value:9.05E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.26|P-value:7.29E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-4.28|P-value:6.93E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.61|P-value:5.50E-7 ID:SGTC_3204|Compound:9114183|FD-Score:4.28|P-value:8.29E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.50|P-value:4.74E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.56|P-value:2.14E-5

Top fitness defect scores for YMR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 16.00 2.4 µM 1.33E-32 endomembrane recycling 18 5.64E-58
2 SGTC_2582 agaric acid 10.70 100.0 µM 1.39E-15 redox potentiating 53 5.04E-27
3 SGTC_255 tunicamycin 9.98 200.5 nM 8.94E-14 unfolded protein response 12 9.69E-24
4 SGTC_2507 purpurin 9.29 79.7 µM 3.59E-12 copper-dependent oxidative stress 4 7.87E-21
5 SGTC_1746 st038117 9.14 42.0 µM 7.65E-12 1 3.09E-20
6 SGTC_824 1304-0008 8.61 100.0 µM 1.06E-10 DNA damage response 2 3.62E-18
7 SGTC_151 3013-0144 8.43 2.3 µM 2.54E-10 iron homeostasis 4 1.76E-17
8 SGTC_2575 plumbagin 8.29 510.0 nM 4.76E-10 superoxide 9 5.49E-17
9 SGTC_2756 carbadox 7.95 75.1 µM 2.26E-9 7 9.21E-16
10 SGTC_2934 9036370 7.73 36.9 µM 5.88E-9 4 5.19E-15
11 SGTC_674 0498-0004 7.59 451.0 µM 1.09E-8 heme requiring 1 1.59E-14
12 SGTC_2741 miltefosine 7.40 3.0 µM 2.50E-8 14 7.07E-14
13 SGTC_3152 9099253 6.61 49.5 µM 5.50E-7 NEO1-PIK1 46 1.87E-11
14 SGTC_548 1436-0017 6.15 110.0 µM 2.96E-6 TSC3-RPN4 9 3.87E-10
15 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 6.06 44.4 nM 4.00E-6 DNA damage response 20 6.65E-10
16 SGTC_453 enantio-paf c16 6.00 10.0 µM 4.91E-6 50 9.61E-10
17 SGTC_2259 7964009 6.00 200.0 µM 5.04E-6 superoxide 12 1.01E-9
18 SGTC_2429 5902844 5.97 64.4 µM 5.61E-6 5 1.22E-9
19 SGTC_312 4092-0653 5.89 6.8 µM 7.34E-6 ergosterol depletion effects on membrane 41 1.98E-9
20 SGTC_712 r015-0009 5.88 80.6 µM 7.55E-6 9 2.08E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 1.98E-43 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.220 7.33E-38 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.216 1.30E-36 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.213 1.34E-35 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.201 8.34E-32 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.199 2.37E-31 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.192 5.98E-29 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.165 6.43E-22 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.163 1.88E-21 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.158 2.93E-20 YPR153W YPR153W hom Putative protein of unknown function
0.158 3.25E-20 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.145 3.70E-17 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.142 1.64E-16 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.140 4.34E-16 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 5.20E-16 YPR040W TIP41 hom Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress