YMR074C

Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR074C / YMR074C

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-3.76|P-value:2.01E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-4.22|P-value:2.00E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.75|P-value:1.98E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.13|P-value:3.25E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:5.14|P-value:9.19E-9 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.93|P-value:8.92E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.01|P-value:4.93E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.09|P-value:3.52E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:-4.68|P-value:1.60E-7 ID:SGTC_509|Compound:pifithrin|FD-Score:-4.32|P-value:1.22E-6 ID:SGTC_510|Compound:ag-490|FD-Score:-3.66|P-value:3.25E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-2.93|P-value:7.09E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.54|P-value:5.51E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:7.36|P-value:4.09E-16 ID:SGTC_666|Compound:0272-0154|FD-Score:6.56|P-value:3.57E-13 ID:SGTC_668|Compound:1682-0499|FD-Score:3.72|P-value:2.25E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:5.48|P-value:1.01E-9 ID:SGTC_916|Compound:4466-0038|FD-Score:2.84|P-value:9.22E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.39|P-value:1.76E-9 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.71|P-value:2.18E-10 ID:SGTC_948|Compound:3448-0295|FD-Score:-6.18|P-value:7.53E-12 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.94|P-value:6.45E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.12|P-value:3.27E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.64|P-value:2.12E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.84|P-value:6.23E-8 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.25|P-value:1.60E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:4.15|P-value:2.73E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-2.96|P-value:6.30E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.86|P-value:1.28E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.96|P-value:6.17E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.98|P-value:5.81E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.12|P-value:3.26E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.63|P-value:3.69E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-5.62|P-value:4.13E-10 ID:SGTC_2284|Compound:7945075|FD-Score:4.03|P-value:5.06E-6 ID:SGTC_2286|Compound:7945697|FD-Score:-3.40|P-value:1.02E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.94|P-value:6.74E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.33|P-value:1.41E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.13|P-value:3.00E-6 ID:SGTC_2521|Compound:angolensin|FD-Score:-2.89|P-value:8.11E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.79|P-value:1.77E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.99|P-value:5.22E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.84|P-value:1.37E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.94|P-value:8.33E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.34|P-value:1.25E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.21|P-value:2.33E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.47|P-value:7.72E-5 ID:SGTC_2869|Compound:9037858|FD-Score:-3.33|P-value:1.39E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.02|P-value:4.88E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.14|P-value:2.91E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.17|P-value:2.67E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-2.87|P-value:8.81E-4 ID:SGTC_3152|Compound:9099253|FD-Score:2.92|P-value:6.87E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.76|P-value:2.01E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-4.22|P-value:2.00E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.75|P-value:1.98E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.13|P-value:3.25E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:5.14|P-value:9.19E-9 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.93|P-value:8.92E-6 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.01|P-value:4.93E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.09|P-value:3.52E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:-4.68|P-value:1.60E-7 ID:SGTC_509|Compound:pifithrin|FD-Score:-4.32|P-value:1.22E-6 ID:SGTC_510|Compound:ag-490|FD-Score:-3.66|P-value:3.25E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-2.93|P-value:7.09E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.54|P-value:5.51E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:7.36|P-value:4.09E-16 ID:SGTC_666|Compound:0272-0154|FD-Score:6.56|P-value:3.57E-13 ID:SGTC_668|Compound:1682-0499|FD-Score:3.72|P-value:2.25E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:5.48|P-value:1.01E-9 ID:SGTC_916|Compound:4466-0038|FD-Score:2.84|P-value:9.22E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.39|P-value:1.76E-9 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.71|P-value:2.18E-10 ID:SGTC_948|Compound:3448-0295|FD-Score:-6.18|P-value:7.53E-12 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.94|P-value:6.45E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.12|P-value:3.27E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.64|P-value:2.12E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.84|P-value:6.23E-8 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.25|P-value:1.60E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:4.15|P-value:2.73E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-2.96|P-value:6.30E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.86|P-value:1.28E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.96|P-value:6.17E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.98|P-value:5.81E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.12|P-value:3.26E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.63|P-value:3.69E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-5.62|P-value:4.13E-10 ID:SGTC_2284|Compound:7945075|FD-Score:4.03|P-value:5.06E-6 ID:SGTC_2286|Compound:7945697|FD-Score:-3.40|P-value:1.02E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.94|P-value:6.74E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.33|P-value:1.41E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.13|P-value:3.00E-6 ID:SGTC_2521|Compound:angolensin|FD-Score:-2.89|P-value:8.11E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.79|P-value:1.77E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.99|P-value:5.22E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.84|P-value:1.37E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.94|P-value:8.33E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.34|P-value:1.25E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.21|P-value:2.33E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.47|P-value:7.72E-5 ID:SGTC_2869|Compound:9037858|FD-Score:-3.33|P-value:1.39E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.02|P-value:4.88E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.14|P-value:2.91E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.17|P-value:2.67E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-2.87|P-value:8.81E-4 ID:SGTC_3152|Compound:9099253|FD-Score:2.92|P-value:6.87E-4

Top fitness defect scores for YMR074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_656 4090-1979 7.36 187.0 µM 4.09E-16 2 9.47E-14
2 SGTC_666 0272-0154 6.56 136.0 µM 3.57E-13 cell wall 17 2.77E-11
3 SGTC_669 0108-0021 5.48 26.2 µM 1.01E-9 fatty acid desaturase (OLE1) 27 2.17E-8
4 SGTC_939 1165-0479 5.39 45.3 µM 1.76E-9 5 3.45E-8
5 SGTC_372 0155-0182 5.14 15.9 µM 9.19E-9 mitochondrial response to ROS 11 1.39E-7
6 SGTC_1525 8-methoxypsoralen 4.25 92.5 µM 1.60E-6 DNA damage response 20 1.06E-5
7 SGTC_1540 guanosine 4.15 70.6 µM 2.73E-6 6 1.66E-5
8 SGTC_2514 salinomycin 4.13 42.7 µM 3.00E-6 39 1.80E-5
9 SGTC_2284 7945075 4.03 39.2 µM 5.06E-6 mitochondrial processes 24 2.79E-5
10 SGTC_309 k408-0051 3.75 1.5 µM 1.98E-5 61 8.80E-5
11 SGTC_668 1682-0499 3.72 62.6 µM 2.25E-5 25 9.81E-5
12 SGTC_2763 lisinopril 3.34 49.3 µM 1.25E-4 20 4.15E-4
13 SGTC_2899 9053889 3.14 58.4 µM 2.91E-4 26 8.48E-4
14 SGTC_500 h-89 3.09 112.0 µM 3.52E-4 cell wall signaling 68 9.97E-4
15 SGTC_410 α-linolenic acid 3.01 100.0 µM 4.93E-4 excess fatty acid 68 0.00132
16 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 2.99 100.0 µM 5.22E-4 76 0.00139
17 SGTC_1333 1482-0047 2.94 286.0 µM 6.45E-4 65 0.00166
18 SGTC_3152 9099253 2.92 49.5 µM 6.87E-4 NEO1-PIK1 223 0.00176
19 SGTC_916 4466-0038 2.84 42.0 nM 9.22E-4 cell wall 165 0.00225
20 SGTC_1246 0422-0085 2.76 105.0 µM 0.00123 105 0.00286

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.295 1.97E-68 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.281 8.86E-62 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.246 2.14E-47 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.230 2.31E-41 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.230 1.58E-41 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.228 6.21E-41 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.223 3.57E-39 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.214 3.53E-36 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.212 2.06E-35 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.200 9.60E-32 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.195 3.50E-30 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.192 4.19E-29 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.189 1.75E-28 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.189 2.43E-28 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.187 1.21E-27 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication