YMR075C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR075C-A / YMR075C-A

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.57|P-value:2.15E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.38|P-value:5.72E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.23|P-value:9.55E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:5.24|P-value:1.35E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:3.70|P-value:1.32E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.05|P-value:3.32E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.50|P-value:4.86E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:3.63|P-value:1.70E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.16|P-value:9.08E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.16|P-value:8.95E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.50|P-value:4.73E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.28|P-value:6.03E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.82|P-value:1.65E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:3.45|P-value:3.36E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.89|P-value:6.41E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.19|P-value:1.84E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.55|P-value:2.33E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.03|P-value:5.14E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.65|P-value:2.23E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.22|P-value:1.62E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.23|P-value:7.07E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.64|P-value:2.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.11|P-value:3.78E-5 ID:SGTC_1991|Compound:st073000|FD-Score:-3.41|P-value:5.25E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.65|P-value:2.45E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.58|P-value:2.07E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.33|P-value:5.09E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.27|P-value:8.49E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.98|P-value:4.47E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.33|P-value:5.06E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.34|P-value:6.66E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.39|P-value:1.16E-5 ID:SGTC_2996|Compound:9066192|FD-Score:3.46|P-value:3.16E-4 ID:SGTC_3194|Compound:9111903|FD-Score:8.55|P-value:2.79E-17 ID:SGTC_3196|Compound:9111891|FD-Score:3.83|P-value:7.92E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.74|P-value:1.50E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:3.57|P-value:2.15E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.38|P-value:5.72E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.23|P-value:9.55E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:5.24|P-value:1.35E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:3.70|P-value:1.32E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.05|P-value:3.32E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.50|P-value:4.86E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:3.63|P-value:1.70E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.16|P-value:9.08E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.16|P-value:8.95E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.50|P-value:4.73E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.28|P-value:6.03E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.82|P-value:1.65E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:3.45|P-value:3.36E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.89|P-value:6.41E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.19|P-value:1.84E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.55|P-value:2.33E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.03|P-value:5.14E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.65|P-value:2.23E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.22|P-value:1.62E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.23|P-value:7.07E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.64|P-value:2.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.11|P-value:3.78E-5 ID:SGTC_1991|Compound:st073000|FD-Score:-3.41|P-value:5.25E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.65|P-value:2.45E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.58|P-value:2.07E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.33|P-value:5.09E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.27|P-value:8.49E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.98|P-value:4.47E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.33|P-value:5.06E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.34|P-value:6.66E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.39|P-value:1.16E-5 ID:SGTC_2996|Compound:9066192|FD-Score:3.46|P-value:3.16E-4 ID:SGTC_3194|Compound:9111903|FD-Score:8.55|P-value:2.79E-17 ID:SGTC_3196|Compound:9111891|FD-Score:3.83|P-value:7.92E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.74|P-value:1.50E-8

Top fitness defect scores for YMR075C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3194 9111903 8.55 49.5 µM 2.79E-17 2 5.97E-18
2 SGTC_306 1672-3436 5.24 11.6 µM 1.35E-7 Golgi 5 8.16E-8
3 SGTC_1999 st074831 4.65 12.5 µM 2.45E-6 plasma membrane duress 18 1.69E-6
4 SGTC_717 1532-0246 4.50 73.2 µM 4.73E-6 Golgi 19 3.35E-6
5 SGTC_582 0987-0078 4.50 156.0 µM 4.86E-6 calcium & mitochondrial duress 48 3.44E-6
6 SGTC_1505 k297-0037 4.22 20.6 µM 1.62E-5 14 1.21E-5
7 SGTC_1007 4101-0031 4.19 70.0 µM 1.84E-5 15 1.38E-5
8 SGTC_581 0958-0271 4.05 211.0 µM 3.32E-5 49 2.55E-5
9 SGTC_2782 7736369 3.98 71.4 µM 4.47E-5 41 3.47E-5
10 SGTC_951 1171-0579 3.89 82.7 µM 6.41E-5 cell wall 86 5.06E-5
11 SGTC_3196 9111891 3.83 49.5 µM 7.92E-5 mitochondrial processes 19 6.30E-5
12 SGTC_577 r071-0003 3.70 38.6 µM 1.32E-4 fatty acid desaturase (OLE1) 68 1.07E-4
13 SGTC_2247 cerulenin 3.68 830.0 nM 1.45E-4 24 1.18E-4
14 SGTC_1804 st050076 3.68 49.1 µM 1.45E-4 21 1.18E-4
15 SGTC_594 1487-1584 3.63 10.8 µM 1.70E-4 32 1.39E-4
16 SGTC_2344 7990960 3.63 77.0 µM 1.72E-4 33 1.41E-4
17 SGTC_2111 5486399 3.58 200.0 µM 2.07E-4 63 1.71E-4
18 SGTC_20 0481-0013 3.57 4.9 µM 2.15E-4 38 1.79E-4
19 SGTC_1017 4239-0030 3.55 168.0 µM 2.33E-4 41 1.94E-4
20 SGTC_2996 9066192 3.46 71.4 µM 3.16E-4 54 2.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.74E-11 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.097 1.58E-8 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.097 2.06E-8 YHR183W GND1 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication
0.085 9.95E-7 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.082 1.95E-6 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.080 3.94E-6 YHR076W PTC7 hom Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
0.077 9.06E-6 YOR100C CRC1 hom Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
0.076 9.49E-6 YIL036W CST6 hom Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.075 1.38E-5 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.074 1.85E-5 YOR147W MDM32 hom Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
0.072 3.23E-5 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.071 3.58E-5 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.070 5.19E-5 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.069 6.68E-5 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.068 8.09E-5 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin