HIPHOP chemogenomics database
YMR075W / RCO1 
Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR075W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.130 | 4.01E-14 | YKR080W | MTD1 | hom | NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline |
| 0.114 | 3.50E-11 | YLR178C | TFS1 | hom | Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress |
| 0.113 | 5.62E-11 | YGR204W | ADE3 | hom | Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine |
| 0.101 | 4.04E-9 | YHR141C | RPL42B | hom | Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication |
| 0.099 | 1.05E-8 | YLR427W | MAG2 | hom | Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 |
| 0.095 | 3.87E-8 | YGL082W_p | YGL082W_p | hom | Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene |
| 0.089 | 2.13E-7 | YDR061W_p | YDR061W_p | hom | Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance |
| 0.085 | 9.23E-7 | YOR345C_d | YOR345C_d | hom | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 |
| 0.082 | 1.81E-6 | YMR300C | ADE4 | hom | Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway |
| 0.082 | 1.95E-6 | YOR209C | NPT1 | hom | Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus |
| 0.080 | 3.42E-6 | YBR054W | YRO2 | hom | Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication |
| 0.080 | 3.52E-6 | YDR540C | IRC4 | hom | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
| 0.078 | 6.40E-6 | YHL003C | LAG1 | hom | Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress |
| 0.077 | 7.00E-6 | YLR188W | MDL1 | hom | Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress |
| 0.077 | 7.63E-6 | YDR042C_p | YDR042C_p | hom | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant |