YMR075W / RCO1

Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR075W / RCO1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.17|P-value:8.81E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.68|P-value:1.37E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.63|P-value:2.35E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.40|P-value:3.53E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.13|P-value:8.97E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.17|P-value:7.79E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.12|P-value:9.20E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.25|P-value:6.56E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.19|P-value:8.08E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.36|P-value:4.50E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.75|P-value:1.33E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.65|P-value:2.14E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.57|P-value:3.12E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.97|P-value:4.43E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.27|P-value:1.21E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.16|P-value:8.08E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.45|P-value:3.24E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.51|P-value:2.68E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.17|P-value:8.85E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.32|P-value:9.67E-6 ID:SGTC_2352|Compound:9027995|FD-Score:3.42|P-value:3.68E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.28|P-value:5.92E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.14|P-value:8.78E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.87|P-value:5.74E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.39|P-value:7.20E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.07|P-value:2.50E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.30|P-value:5.56E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.44|P-value:3.66E-8 ID:SGTC_2703|Compound:st077852|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.96|P-value:4.63E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.73|P-value:1.12E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.68|P-value:1.24E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-6.37|P-value:1.19E-10 ID:SGTC_3212|Compound:9128307|FD-Score:3.66|P-value:1.50E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.88|P-value:6.20E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.37|P-value:4.33E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.17|P-value:1.86E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.17|P-value:8.81E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.68|P-value:1.37E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.63|P-value:2.35E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.40|P-value:3.53E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.13|P-value:8.97E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.17|P-value:7.79E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.12|P-value:9.20E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.25|P-value:6.56E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.19|P-value:8.08E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.36|P-value:4.50E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.75|P-value:1.33E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.65|P-value:2.14E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.57|P-value:3.12E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.97|P-value:4.43E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.27|P-value:1.21E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.16|P-value:8.08E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.45|P-value:3.24E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.51|P-value:2.68E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.17|P-value:8.85E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.32|P-value:9.67E-6 ID:SGTC_2352|Compound:9027995|FD-Score:3.42|P-value:3.68E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.28|P-value:5.92E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.14|P-value:8.78E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.87|P-value:5.74E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.39|P-value:7.20E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.07|P-value:2.50E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.30|P-value:5.56E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.44|P-value:3.66E-8 ID:SGTC_2703|Compound:st077852|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.96|P-value:4.63E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.73|P-value:1.12E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.68|P-value:1.24E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-6.37|P-value:1.19E-10 ID:SGTC_3212|Compound:9128307|FD-Score:3.66|P-value:1.50E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.88|P-value:6.20E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.37|P-value:4.33E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.17|P-value:1.86E-5

Top fitness defect scores for YMR075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2635 hydroquinidine 5.44 100.0 µM 3.66E-8 4 2.64E-8
2 SGTC_1017 4239-0030 4.75 168.0 µM 1.33E-6 11 1.02E-6
3 SGTC_1028 k015-0029 4.65 4.8 µM 2.14E-6 12 1.66E-6
4 SGTC_343 4130-2827 4.63 29.8 µM 2.35E-6 18 1.83E-6
5 SGTC_1190 1486-1332 4.57 13.0 µM 3.12E-6 6 2.44E-6
6 SGTC_2507 purpurin 4.39 79.7 µM 7.20E-6 copper-dependent oxidative stress 27 5.72E-6
7 SGTC_2264 7948757 4.32 110.8 µM 9.67E-6 8 7.73E-6
8 SGTC_1390 3413-2614 4.27 145.0 µM 1.21E-5 fatty acid desaturase (OLE1) 17 9.70E-6
9 SGTC_2499 avocadenofuran 4.21 51.5 µM 1.62E-5 31 1.30E-5
10 SGTC_3331 9141060 4.17 2.0 µM 1.86E-5 cell wall 29 1.50E-5
11 SGTC_1312 1218-2183 3.97 165.0 µM 4.43E-5 7 3.64E-5
12 SGTC_3062 9077494 3.96 49.5 µM 4.63E-5 mitochondrial response to ROS 37 3.81E-5
13 SGTC_3245 9134821 3.88 49.5 µM 6.20E-5 18 5.13E-5
14 SGTC_3136 9095672 3.73 49.5 µM 1.12E-4 29 9.41E-5
15 SGTC_116 0155-0182 3.68 31.8 µM 1.37E-4 mitochondrial response to ROS 100 1.15E-4
16 SGTC_3212 9128307 3.66 49.5 µM 1.50E-4 59 1.27E-4
17 SGTC_123 0083-0120 3.57 66.7 µM 2.13E-4 60 1.81E-4
18 SGTC_2703 st077852 3.52 53.4 µM 2.57E-4 39 2.19E-4
19 SGTC_2258 7960471 3.51 200.0 µM 2.68E-4 21 2.28E-4
20 SGTC_796 1234-0020 3.49 70.7 µM 2.84E-4 SWF1 & branched chain AA biosynthesis 39 2.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.01E-14 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.114 3.50E-11 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.113 5.62E-11 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.101 4.04E-9 YHR141C RPL42B hom Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication
0.099 1.05E-8 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.095 3.87E-8 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.089 2.13E-7 YDR061W_p YDR061W_p hom Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.085 9.23E-7 YOR345C_d YOR345C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.082 1.81E-6 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
0.082 1.95E-6 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.080 3.42E-6 YBR054W YRO2 hom Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication
0.080 3.52E-6 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.078 6.40E-6 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.077 7.00E-6 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.077 7.63E-6 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant