HIPHOP chemogenomics database

YMR076C / PDS5

Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis

Zygosity: Heterozygous strain

fixedexpanded
Profile for YMR076C / PDS5

Click on Significant Values for Screen Details

Top fitness defect scores for YMR076C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_3156	9099931	5.02	49.5 µM	5.12E-7		1	2.60E-7	1.26
2	SGTC_3131	9127911	5.00	49.5 µM	5.53E-7		4	2.82E-7	0.20
3	SGTC_124	0136-0217	4.92	7.1 µM	8.28E-7	mitochondrial stress	15	4.31E-7	0.12
4	SGTC_936	3005-4620	4.77	401.0 µM	1.72E-6		2	9.31E-7	0.52
5	SGTC_1775	st081588	4.67	35.2 µM	2.75E-6	60S ribosome export	10	1.52E-6	0.80
6	SGTC_2835	9006588	4.63	71.4 µM	3.32E-6		6	1.85E-6	0.09
7	SGTC_2591	skatole	4.58	100.0 µM	4.19E-6		2	2.36E-6	0.08
8	SGTC_2988	9073640	4.32	71.4 µM	1.30E-5		9	7.75E-6	0.01
9	SGTC_359	0081-0058	4.28	15.9 µM	1.57E-5	60S ribosome export	11	9.48E-6	0.19
10	SGTC_130	0136-0219	4.26	337.7 µM	1.67E-5		8	1.01E-5	0.10
11	SGTC_2848	9016370	4.21	26.0 µM	2.05E-5		2	1.26E-5	0.27
12	SGTC_1738	st035555	3.95	74.0 µM	6.00E-5	TSC3-RPN4	4	3.87E-5	0.08
13	SGTC_2092	5303694	3.95	80.7 µM	6.16E-5	TSC3-RPN4	7	3.98E-5	0.18
14	SGTC_2977	9011197	3.93	71.4 µM	6.63E-5		9	4.30E-5	0.03
15	SGTC_1284	0929-0043	3.87	16.0 µM	8.44E-5		4	5.54E-5	0.40
16	SGTC_764	1951-2361	3.82	146.0 µM	9.98E-5		15	6.61E-5	0.01
17	SGTC_3090	9117696	3.80	49.5 µM	1.09E-4		3	7.26E-5	0.53
18	SGTC_552	k242-0005	3.74	476.0 µM	1.37E-4		3	9.21E-5	0.52
19	SGTC_3020	9089140	3.72	49.5 µM	1.49E-4		11	1.00E-4	0.10
20	SGTC_364	0083-0097	3.67	67.7 µM	1.81E-4		10	1.24E-4	0.28

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.110	1.88E-10	YER118C	SHO1	hom	Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.094	4.52E-8	YGR204W	ADE3	hom	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.079	5.29E-6	YLR433C	CNA1	hom	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.078	6.61E-6	YLR058C	SHM2	hom	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.077	7.79E-6	YPR066W	UBA3	hom	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.077	8.86E-6	YKR080W	MTD1	hom	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.077	8.96E-6	YLR138W	NHA1	hom	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
0.075	1.27E-5	YOR159C	SME1	het	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.074	1.57E-5	YLR141W	RRN5	het	Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.073	2.33E-5	YOR192C	THI72	hom	Transporter of thiamine or related compound; shares sequence similarity with Thi7p
0.072	3.10E-5	YEL008W_d	YEL008W_d	hom	Hypothetical protein predicted to be involved in metabolism
0.071	4.09E-5	YLR438C-A	LSM3	het	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.069	6.53E-5	YNL265C	IST1	hom	Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
0.068	8.40E-5	YGL207W	SPT16	het	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.067	1.06E-4	YOR109W	INP53	hom	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains