YMR076C / PDS5

Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR076C / PDS5

Click on Significant Values for Screen Details ID:SGTC_123|Compound:0083-0120|FD-Score:3.30|P-value:6.70E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.92|P-value:8.28E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:4.26|P-value:1.67E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.62|P-value:2.16E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.28|P-value:1.57E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.67|P-value:1.81E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.74|P-value:1.37E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.22|P-value:8.66E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.33|P-value:5.93E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.49|P-value:3.13E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.82|P-value:9.98E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.34|P-value:5.85E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.77|P-value:1.72E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.75|P-value:1.22E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.28|P-value:6.65E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.87|P-value:8.44E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.59|P-value:2.24E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.35|P-value:5.56E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.95|P-value:6.00E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.47|P-value:3.68E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.67|P-value:2.75E-6 ID:SGTC_1799|Compound:st045822|FD-Score:-3.73|P-value:1.32E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.34|P-value:5.79E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.95|P-value:6.16E-5 ID:SGTC_2118|Compound:5526350|FD-Score:-4.75|P-value:1.69E-6 ID:SGTC_2157|Compound:5649910|FD-Score:3.40|P-value:4.74E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.53|P-value:2.72E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.24|P-value:7.47E-4 ID:SGTC_2355|Compound:9061122|FD-Score:-3.32|P-value:5.82E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.92|P-value:6.15E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.58|P-value:4.19E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.40|P-value:4.66E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.39|P-value:4.95E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.63|P-value:3.32E-6 ID:SGTC_2848|Compound:9016370|FD-Score:4.21|P-value:2.05E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.93|P-value:6.63E-5 ID:SGTC_2988|Compound:9073640|FD-Score:4.32|P-value:1.30E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.59|P-value:2.35E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.72|P-value:1.49E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-5.36|P-value:7.90E-8 ID:SGTC_3036|Compound:9090181|FD-Score:3.56|P-value:2.71E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.80|P-value:1.09E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-4.42|P-value:7.61E-6 ID:SGTC_3131|Compound:9127911|FD-Score:5.00|P-value:5.53E-7 ID:SGTC_3133|Compound:9127736|FD-Score:-3.34|P-value:5.32E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.41|P-value:4.49E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-5.43|P-value:5.38E-8 ID:SGTC_3156|Compound:9099931|FD-Score:5.02|P-value:5.12E-7 ID:SGTC_3290|Compound:9121031|FD-Score:3.48|P-value:3.55E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.30|P-value:6.70E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.92|P-value:8.28E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:4.26|P-value:1.67E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.62|P-value:2.16E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.28|P-value:1.57E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.67|P-value:1.81E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.74|P-value:1.37E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.22|P-value:8.66E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.33|P-value:5.93E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.49|P-value:3.13E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.82|P-value:9.98E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.34|P-value:5.85E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.77|P-value:1.72E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.75|P-value:1.22E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.28|P-value:6.65E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.87|P-value:8.44E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.59|P-value:2.24E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.35|P-value:5.56E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.95|P-value:6.00E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.47|P-value:3.68E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.67|P-value:2.75E-6 ID:SGTC_1799|Compound:st045822|FD-Score:-3.73|P-value:1.32E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.34|P-value:5.79E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.95|P-value:6.16E-5 ID:SGTC_2118|Compound:5526350|FD-Score:-4.75|P-value:1.69E-6 ID:SGTC_2157|Compound:5649910|FD-Score:3.40|P-value:4.74E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.53|P-value:2.72E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.24|P-value:7.47E-4 ID:SGTC_2355|Compound:9061122|FD-Score:-3.32|P-value:5.82E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.92|P-value:6.15E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.58|P-value:4.19E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.40|P-value:4.66E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.39|P-value:4.95E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.63|P-value:3.32E-6 ID:SGTC_2848|Compound:9016370|FD-Score:4.21|P-value:2.05E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.93|P-value:6.63E-5 ID:SGTC_2988|Compound:9073640|FD-Score:4.32|P-value:1.30E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.59|P-value:2.35E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.72|P-value:1.49E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-5.36|P-value:7.90E-8 ID:SGTC_3036|Compound:9090181|FD-Score:3.56|P-value:2.71E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.80|P-value:1.09E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-4.42|P-value:7.61E-6 ID:SGTC_3131|Compound:9127911|FD-Score:5.00|P-value:5.53E-7 ID:SGTC_3133|Compound:9127736|FD-Score:-3.34|P-value:5.32E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.41|P-value:4.49E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-5.43|P-value:5.38E-8 ID:SGTC_3156|Compound:9099931|FD-Score:5.02|P-value:5.12E-7 ID:SGTC_3290|Compound:9121031|FD-Score:3.48|P-value:3.55E-4

Top fitness defect scores for YMR076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3156 9099931 5.02 49.5 µM 5.12E-7 1 2.60E-7 1.26
2 SGTC_3131 9127911 5.00 49.5 µM 5.53E-7 4 2.82E-7 0.20
3 SGTC_124 0136-0217 4.92 7.1 µM 8.28E-7 mitochondrial stress 15 4.31E-7 0.12
4 SGTC_936 3005-4620 4.77 401.0 µM 1.72E-6 2 9.31E-7 0.52
5 SGTC_1775 st081588 4.67 35.2 µM 2.75E-6 60S ribosome export 10 1.52E-6 0.80
6 SGTC_2835 9006588 4.63 71.4 µM 3.32E-6 6 1.85E-6 0.09
7 SGTC_2591 skatole 4.58 100.0 µM 4.19E-6 2 2.36E-6 0.08
8 SGTC_2988 9073640 4.32 71.4 µM 1.30E-5 9 7.75E-6 0.01
9 SGTC_359 0081-0058 4.28 15.9 µM 1.57E-5 60S ribosome export 11 9.48E-6 0.19
10 SGTC_130 0136-0219 4.26 337.7 µM 1.67E-5 8 1.01E-5 0.10
11 SGTC_2848 9016370 4.21 26.0 µM 2.05E-5 2 1.26E-5 0.27
12 SGTC_1738 st035555 3.95 74.0 µM 6.00E-5 TSC3-RPN4 4 3.87E-5 0.08
13 SGTC_2092 5303694 3.95 80.7 µM 6.16E-5 TSC3-RPN4 7 3.98E-5 0.18
14 SGTC_2977 9011197 3.93 71.4 µM 6.63E-5 9 4.30E-5 0.03
15 SGTC_1284 0929-0043 3.87 16.0 µM 8.44E-5 4 5.54E-5 0.40
16 SGTC_764 1951-2361 3.82 146.0 µM 9.98E-5 15 6.61E-5 0.01
17 SGTC_3090 9117696 3.80 49.5 µM 1.09E-4 3 7.26E-5 0.53
18 SGTC_552 k242-0005 3.74 476.0 µM 1.37E-4 3 9.21E-5 0.52
19 SGTC_3020 9089140 3.72 49.5 µM 1.49E-4 11 1.00E-4 0.10
20 SGTC_364 0083-0097 3.67 67.7 µM 1.81E-4 10 1.24E-4 0.28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.88E-10 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.094 4.52E-8 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.079 5.29E-6 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.078 6.61E-6 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.077 7.79E-6 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.077 8.86E-6 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.077 8.96E-6 YLR138W NHA1 hom Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
0.075 1.27E-5 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.074 1.57E-5 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.073 2.33E-5 YOR192C THI72 hom Transporter of thiamine or related compound; shares sequence similarity with Thi7p
0.072 3.10E-5 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.071 4.09E-5 YLR438C-A LSM3 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.069 6.53E-5 YNL265C IST1 hom Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
0.068 8.40E-5 YGL207W SPT16 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.067 1.06E-4 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains