YMR077C / VPS20

Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR077C / VPS20

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.92|P-value:9.03E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.26|P-value:2.80E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:7.60|P-value:2.50E-11 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.70|P-value:6.28E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.98|P-value:1.17E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.55|P-value:3.73E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.37|P-value:6.98E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:5.37|P-value:1.79E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.84|P-value:4.11E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-6.51|P-value:7.26E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:4.23|P-value:1.33E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.46|P-value:5.12E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:9.75|P-value:1.64E-17 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.00|P-value:2.76E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:5.08|P-value:5.62E-6 ID:SGTC_232|Compound:clozapine|FD-Score:3.75|P-value:6.02E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.22|P-value:3.31E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.20|P-value:1.47E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:7.63|P-value:2.09E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.82|P-value:1.36E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.00|P-value:2.44E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.07|P-value:2.19E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.07|P-value:1.94E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.35|P-value:8.69E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.97|P-value:1.21E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:4.30|P-value:1.03E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.10|P-value:5.29E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:3.63|P-value:8.87E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.92|P-value:3.63E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.11|P-value:6.34E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:4.15|P-value:1.71E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.03|P-value:7.09E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:5.71|P-value:3.96E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:9.43|P-value:1.68E-16 ID:SGTC_900|Compound:1112-0045|FD-Score:6.29|P-value:2.76E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:6.41|P-value:1.48E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.92|P-value:1.54E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.09|P-value:2.10E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.67|P-value:2.76E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.03|P-value:7.01E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.59|P-value:9.72E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.66|P-value:8.01E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.09|P-value:2.07E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.32|P-value:9.73E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.03|P-value:7.11E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.30|P-value:9.03E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:14.90|P-value:1.82E-38 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.16|P-value:1.45E-4 ID:SGTC_1687|Compound:st020778|FD-Score:9.04|P-value:2.58E-15 ID:SGTC_1750|Compound:st081859|FD-Score:5.95|P-value:1.34E-7 ID:SGTC_1760|Compound:st045453|FD-Score:5.71|P-value:4.01E-7 ID:SGTC_1781|Compound:st038725|FD-Score:6.70|P-value:3.47E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.97|P-value:1.26E-7 ID:SGTC_1801|Compound:st050089|FD-Score:5.15|P-value:4.34E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.60|P-value:6.41E-7 ID:SGTC_1804|Compound:st050076|FD-Score:3.67|P-value:7.83E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.47|P-value:5.69E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-4.41|P-value:6.02E-5 ID:SGTC_1884|Compound:5633444|FD-Score:12.50|P-value:1.85E-27 ID:SGTC_1912|Compound:st060209|FD-Score:5.54|P-value:8.51E-7 ID:SGTC_2016|Compound:5121758|FD-Score:7.84|P-value:6.02E-12 ID:SGTC_2065|Compound:5221596|FD-Score:4.60|P-value:3.51E-5 ID:SGTC_2071|Compound:5230951|FD-Score:5.04|P-value:6.69E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.96|P-value:3.14E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.69|P-value:7.41E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.43|P-value:1.37E-6 ID:SGTC_2385|Compound:9074692|FD-Score:3.88|P-value:4.09E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.59|P-value:9.73E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.16|P-value:8.50E-13 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.09|P-value:4.32E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:6.90|P-value:1.21E-9 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.17|P-value:1.60E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.16|P-value:1.67E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.67|P-value:7.88E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.70|P-value:2.46E-5 ID:SGTC_2699|Compound:st077704|FD-Score:5.93|P-value:1.49E-7 ID:SGTC_2709|Compound:st078560|FD-Score:-4.05|P-value:2.04E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.85|P-value:3.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.23|P-value:1.30E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.90|P-value:3.40E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.63|P-value:8.63E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.64|P-value:3.12E-5 ID:SGTC_2930|Compound:9013230|FD-Score:5.84|P-value:2.28E-7 ID:SGTC_2937|Compound:9044753|FD-Score:3.88|P-value:4.04E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.81|P-value:1.53E-9 ID:SGTC_3273|Compound:9137859|FD-Score:4.13|P-value:1.80E-4 ID:SGTC_3279|Compound:9140807|FD-Score:6.44|P-value:1.32E-8 ID:SGTC_3285|Compound:9112818|FD-Score:4.38|P-value:7.93E-5 ID:SGTC_3296|Compound:9122258|FD-Score:4.51|P-value:5.00E-5 ID:SGTC_3302|Compound:9125395|FD-Score:4.04|P-value:2.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.15|P-value:1.72E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.56|P-value:3.02E-11 ID:SGTC_3308|Compound:9128332|FD-Score:8.82|P-value:1.17E-14 ID:SGTC_3319|Compound:9138450|FD-Score:3.91|P-value:3.72E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.92|P-value:9.03E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.26|P-value:2.80E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:7.60|P-value:2.50E-11 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.70|P-value:6.28E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.98|P-value:1.17E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.55|P-value:3.73E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.37|P-value:6.98E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:5.37|P-value:1.79E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.84|P-value:4.11E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-6.51|P-value:7.26E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:4.23|P-value:1.33E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.46|P-value:5.12E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:9.75|P-value:1.64E-17 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.00|P-value:2.76E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:5.08|P-value:5.62E-6 ID:SGTC_232|Compound:clozapine|FD-Score:3.75|P-value:6.02E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.22|P-value:3.31E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.20|P-value:1.47E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:7.63|P-value:2.09E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.82|P-value:1.36E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.00|P-value:2.44E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.07|P-value:2.19E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.07|P-value:1.94E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.35|P-value:8.69E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.97|P-value:1.21E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:4.30|P-value:1.03E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.10|P-value:5.29E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:3.63|P-value:8.87E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.92|P-value:3.63E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.11|P-value:6.34E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:4.15|P-value:1.71E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.03|P-value:7.09E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:5.71|P-value:3.96E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:9.43|P-value:1.68E-16 ID:SGTC_900|Compound:1112-0045|FD-Score:6.29|P-value:2.76E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:6.41|P-value:1.48E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.92|P-value:1.54E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.09|P-value:2.10E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.67|P-value:2.76E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.03|P-value:7.01E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.59|P-value:9.72E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.66|P-value:8.01E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.09|P-value:2.07E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.32|P-value:9.73E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.03|P-value:7.11E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.30|P-value:9.03E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:14.90|P-value:1.82E-38 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.16|P-value:1.45E-4 ID:SGTC_1687|Compound:st020778|FD-Score:9.04|P-value:2.58E-15 ID:SGTC_1750|Compound:st081859|FD-Score:5.95|P-value:1.34E-7 ID:SGTC_1760|Compound:st045453|FD-Score:5.71|P-value:4.01E-7 ID:SGTC_1781|Compound:st038725|FD-Score:6.70|P-value:3.47E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.97|P-value:1.26E-7 ID:SGTC_1801|Compound:st050089|FD-Score:5.15|P-value:4.34E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.60|P-value:6.41E-7 ID:SGTC_1804|Compound:st050076|FD-Score:3.67|P-value:7.83E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.47|P-value:5.69E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-4.41|P-value:6.02E-5 ID:SGTC_1884|Compound:5633444|FD-Score:12.50|P-value:1.85E-27 ID:SGTC_1912|Compound:st060209|FD-Score:5.54|P-value:8.51E-7 ID:SGTC_2016|Compound:5121758|FD-Score:7.84|P-value:6.02E-12 ID:SGTC_2065|Compound:5221596|FD-Score:4.60|P-value:3.51E-5 ID:SGTC_2071|Compound:5230951|FD-Score:5.04|P-value:6.69E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.96|P-value:3.14E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.69|P-value:7.41E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.43|P-value:1.37E-6 ID:SGTC_2385|Compound:9074692|FD-Score:3.88|P-value:4.09E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.59|P-value:9.73E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.16|P-value:8.50E-13 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.09|P-value:4.32E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:6.90|P-value:1.21E-9 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.17|P-value:1.60E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.16|P-value:1.67E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.67|P-value:7.88E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.70|P-value:2.46E-5 ID:SGTC_2699|Compound:st077704|FD-Score:5.93|P-value:1.49E-7 ID:SGTC_2709|Compound:st078560|FD-Score:-4.05|P-value:2.04E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.85|P-value:3.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.23|P-value:1.30E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.90|P-value:3.40E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.63|P-value:8.63E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.64|P-value:3.12E-5 ID:SGTC_2930|Compound:9013230|FD-Score:5.84|P-value:2.28E-7 ID:SGTC_2937|Compound:9044753|FD-Score:3.88|P-value:4.04E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.81|P-value:1.53E-9 ID:SGTC_3273|Compound:9137859|FD-Score:4.13|P-value:1.80E-4 ID:SGTC_3279|Compound:9140807|FD-Score:6.44|P-value:1.32E-8 ID:SGTC_3285|Compound:9112818|FD-Score:4.38|P-value:7.93E-5 ID:SGTC_3296|Compound:9122258|FD-Score:4.51|P-value:5.00E-5 ID:SGTC_3302|Compound:9125395|FD-Score:4.04|P-value:2.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.15|P-value:1.72E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.56|P-value:3.02E-11 ID:SGTC_3308|Compound:9128332|FD-Score:8.82|P-value:1.17E-14 ID:SGTC_3319|Compound:9138450|FD-Score:3.91|P-value:3.72E-4

Top fitness defect scores for YMR077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 14.90 54.9 µM 1.82E-38 redox potentiating 5 1.36E-50
2 SGTC_1884 5633444 12.50 25.0 µM 1.85E-27 redox potentiating 7 5.76E-36
3 SGTC_206 4546-0025 9.75 72.0 µM 1.64E-17 NEO1 14 9.41E-23
4 SGTC_888 0916-0002 9.43 7.0 µM 1.68E-16 NEO1 11 2.06E-21
5 SGTC_1687 st020778 9.04 55.4 µM 2.58E-15 56 7.79E-20
6 SGTC_3308 9128332 8.82 17.6 µM 1.17E-14 plasma membrane duress 26 5.80E-19
7 SGTC_2567 aureobasidin a 8.16 60.0 nM 8.50E-13 21 1.71E-16
8 SGTC_2016 5121758 7.84 140.0 µM 6.02E-12 redox potentiating 5 2.29E-15
9 SGTC_301 4119-0100 7.63 24.5 µM 2.09E-11 NEO1 22 1.19E-14
10 SGTC_117 lucigenin 7.60 22.1 µM 2.50E-11 redox potentiating 22 1.52E-14
11 SGTC_3304 9125678 7.56 46.1 µM 3.02E-11 6 1.94E-14
12 SGTC_2582 agaric acid 7.09 100.0 µM 4.32E-10 redox potentiating 125 6.61E-13
13 SGTC_2619 obliquin 6.90 87.9 µM 1.21E-9 cell wall 60 2.59E-12
14 SGTC_1781 st038725 6.70 66.3 µM 3.47E-9 NEO1 44 1.04E-11
15 SGTC_3279 9140807 6.44 49.5 µM 1.32E-8 5 6.10E-11
16 SGTC_978 1416-0512 6.41 87.4 µM 1.48E-8 redox potentiating 5 7.14E-11
17 SGTC_900 1112-0045 6.29 141.0 µM 2.76E-8 NEO1 11 1.63E-10
18 SGTC_748 0136-0228 6.11 77.9 µM 6.34E-8 redox potentiating 34 4.89E-10
19 SGTC_156 3474-0145 5.98 5.6 µM 1.17E-7 endomembrane recycling 21 1.10E-9
20 SGTC_576 1073-0113 5.97 22.7 µM 1.21E-7 redox potentiating 17 1.15E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.520 2.69E-231 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.508 1.41E-219 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.506 6.47E-217 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.505 1.40E-216 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.499 1.19E-210 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.463 7.38E-178 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.343 5.35E-93 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.324 1.48E-82 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.320 1.98E-80 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.319 3.48E-80 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.307 3.16E-74 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.307 3.78E-74 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.293 1.52E-67 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.280 2.09E-61 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.277 7.24E-60 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC