YMR078C / CTF18

Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR078C / CTF18

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.27|P-value:3.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.28|P-value:6.81E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:3.31|P-value:2.57E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.42|P-value:8.06E-9 ID:SGTC_963|Compound:1269-2853|FD-Score:5.60|P-value:2.66E-9 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.16|P-value:6.82E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.69|P-value:9.11E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.15|P-value:3.89E-8 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.10|P-value:8.97E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.97|P-value:1.67E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.24|P-value:3.37E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.12|P-value:5.28E-4 ID:SGTC_1766|Compound:st045414|FD-Score:2.96|P-value:9.21E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.12|P-value:5.25E-4 ID:SGTC_1830|Compound:st055982|FD-Score:-3.21|P-value:5.73E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.03|P-value:7.21E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.77|P-value:6.58E-5 ID:SGTC_1944|Compound:st076371|FD-Score:6.02|P-value:1.80E-10 ID:SGTC_1947|Compound:st076332|FD-Score:3.10|P-value:5.66E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-3.28|P-value:4.51E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.81|P-value:2.59E-7 ID:SGTC_2104|Compound:5389443|FD-Score:4.21|P-value:5.31E-6 ID:SGTC_2148|Compound:5546263|FD-Score:4.48|P-value:1.47E-6 ID:SGTC_2276|Compound:7947513|FD-Score:3.50|P-value:1.24E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.29|P-value:3.75E-6 ID:SGTC_2476|Compound:5806916|FD-Score:3.09|P-value:5.91E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.91|P-value:3.64E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.85|P-value:4.53E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.42|P-value:1.65E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.77|P-value:3.98E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.58|P-value:8.68E-5 ID:SGTC_2837|Compound:9008476|FD-Score:2.97|P-value:8.95E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.65|P-value:6.48E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.72|P-value:4.94E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.07|P-value:6.20E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.08|P-value:9.33E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.42|P-value:1.67E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.59|P-value:8.59E-5 ID:SGTC_3350|Compound:9150499|FD-Score:4.38|P-value:2.42E-6 ID:SGTC_11|Compound:0438-0307|FD-Score:3.27|P-value:3.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.28|P-value:6.81E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:3.31|P-value:2.57E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.42|P-value:8.06E-9 ID:SGTC_963|Compound:1269-2853|FD-Score:5.60|P-value:2.66E-9 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.16|P-value:6.82E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.69|P-value:9.11E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.15|P-value:3.89E-8 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.10|P-value:8.97E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.97|P-value:1.67E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.24|P-value:3.37E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.12|P-value:5.28E-4 ID:SGTC_1766|Compound:st045414|FD-Score:2.96|P-value:9.21E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.12|P-value:5.25E-4 ID:SGTC_1830|Compound:st055982|FD-Score:-3.21|P-value:5.73E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.03|P-value:7.21E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.77|P-value:6.58E-5 ID:SGTC_1944|Compound:st076371|FD-Score:6.02|P-value:1.80E-10 ID:SGTC_1947|Compound:st076332|FD-Score:3.10|P-value:5.66E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-3.28|P-value:4.51E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.81|P-value:2.59E-7 ID:SGTC_2104|Compound:5389443|FD-Score:4.21|P-value:5.31E-6 ID:SGTC_2148|Compound:5546263|FD-Score:4.48|P-value:1.47E-6 ID:SGTC_2276|Compound:7947513|FD-Score:3.50|P-value:1.24E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.29|P-value:3.75E-6 ID:SGTC_2476|Compound:5806916|FD-Score:3.09|P-value:5.91E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.91|P-value:3.64E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.85|P-value:4.53E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.42|P-value:1.65E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.77|P-value:3.98E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.58|P-value:8.68E-5 ID:SGTC_2837|Compound:9008476|FD-Score:2.97|P-value:8.95E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.65|P-value:6.48E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.72|P-value:4.94E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.07|P-value:6.20E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.08|P-value:9.33E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.42|P-value:1.67E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.59|P-value:8.59E-5 ID:SGTC_3350|Compound:9150499|FD-Score:4.38|P-value:2.42E-6

Top fitness defect scores for YMR078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1944 st076371 6.02 56.9 µM 1.80E-10 4 8.56E-10
2 SGTC_963 1269-2853 5.60 151.0 µM 2.66E-9 6 1.05E-8
3 SGTC_956 1185-0240 5.42 191.0 µM 8.06E-9 10 2.96E-8
4 SGTC_1375 2910-0797 5.15 186.0 µM 3.89E-8 10 1.29E-7
5 SGTC_2064 5220758 4.81 200.0 µM 2.59E-7 14 7.54E-7
6 SGTC_2148 5546263 4.48 113.6 µM 1.47E-6 14 3.79E-6
7 SGTC_3350 9150499 4.38 3.6 µM 2.42E-6 cell wall 38 6.04E-6
8 SGTC_2302 7771753 4.29 200.0 µM 3.75E-6 35 9.09E-6
9 SGTC_2104 5389443 4.21 200.0 µM 5.31E-6 9 1.26E-5
10 SGTC_1394 3474-0001 4.10 65.7 µM 8.97E-6 endomembrane recycling 40 2.05E-5
11 SGTC_1408 3909-7976 3.97 48.8 µM 1.67E-5 Golgi 19 3.66E-5
12 SGTC_2820 7989630 3.77 71.4 µM 3.98E-5 ERG2 30 8.20E-5
13 SGTC_3071 9117417 3.72 49.5 µM 4.94E-5 fatty acid desaturase (OLE1) 22 1.00E-4
14 SGTC_3050 9093513 3.65 49.5 µM 6.48E-5 23 1.29E-4
15 SGTC_3342 9147791 3.59 14.5 µM 8.59E-5 28 1.68E-4
16 SGTC_2827 7993847 3.58 71.4 µM 8.68E-5 36 1.70E-4
17 SGTC_1013 4112-3890 3.54 241.0 µM 1.02E-4 TSC3-RPN4 50 1.98E-4
18 SGTC_2292 7671323 3.52 168.1 µM 1.14E-4 RNA processing & uracil transport 50 2.19E-4
19 SGTC_2276 7947513 3.50 42.1 µM 1.24E-4 35 2.36E-4
20 SGTC_2576 guaiol 3.42 23.1 µM 1.65E-4 44 3.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.32E-12 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.094 5.43E-8 YNR057C BIO4 hom Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
0.092 1.12E-7 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.082 2.09E-6 YNL297C MON2 hom Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
0.081 2.89E-6 YMR246W FAA4 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
0.080 3.52E-6 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.079 4.79E-6 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.078 6.16E-6 YBL056W PTC3 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication
0.078 6.46E-6 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.078 6.62E-6 YJR057W CDC8 het Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
0.077 9.29E-6 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.071 3.51E-5 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.070 4.54E-5 YDR111C_p ALT2_p hom Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p
0.070 4.58E-5 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.070 4.97E-5 YHR075C PPE1 hom Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein