YMR079W / SEC14

Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR079W / SEC14

Click on Significant Values for Screen Details ID:SGTC_122|Compound:0236-0016|FD-Score:3.86|P-value:1.37E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:13.40|P-value:3.13E-37 ID:SGTC_317|Compound:4495-0002|FD-Score:3.31|P-value:9.04E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.21|P-value:4.35E-7 ID:SGTC_347|Compound:4534-1311|FD-Score:3.81|P-value:1.63E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.47|P-value:5.14E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.09|P-value:4.59E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:4.07|P-value:6.27E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:5.22|P-value:4.32E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.78|P-value:3.12E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:5.31|P-value:2.70E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.53|P-value:4.42E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.61|P-value:3.36E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.56|P-value:3.92E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.96|P-value:9.42E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.66|P-value:2.80E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.96|P-value:9.33E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.97|P-value:9.07E-9 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.37|P-value:7.50E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-6.17|P-value:2.64E-9 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.19|P-value:4.80E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.37|P-value:7.21E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.75|P-value:2.05E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.29|P-value:9.59E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.92|P-value:1.08E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-4.28|P-value:2.58E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.39|P-value:6.96E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:11.60|P-value:4.46E-28 ID:SGTC_1666|Compound:st014829|FD-Score:4.59|P-value:7.37E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:40.90|P-value:0 ID:SGTC_1722|Compound:st034304|FD-Score:4.71|P-value:4.36E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.41|P-value:1.68E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.54|P-value:4.24E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.24|P-value:3.19E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.40|P-value:6.81E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.32|P-value:8.63E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.88|P-value:1.21E-4 ID:SGTC_2363|Compound:9053361|FD-Score:12.10|P-value:1.21E-30 ID:SGTC_2367|Compound:9070478|FD-Score:4.85|P-value:2.36E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.98|P-value:8.82E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:4.01|P-value:7.74E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.67|P-value:5.34E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.00|P-value:1.18E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.95|P-value:9.41E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.03|P-value:7.22E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.49|P-value:4.99E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.24|P-value:3.02E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.71|P-value:2.31E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.02|P-value:7.61E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-3.95|P-value:9.48E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.99|P-value:1.19E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.93|P-value:1.04E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.95|P-value:9.22E-5 ID:SGTC_3149|Compound:9097855|FD-Score:22.60|P-value:5.88E-101 ID:SGTC_3152|Compound:9099253|FD-Score:-3.28|P-value:9.64E-4 ID:SGTC_3219|Compound:9131112|FD-Score:26.50|P-value:3.11E-138 ID:SGTC_122|Compound:0236-0016|FD-Score:3.86|P-value:1.37E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:13.40|P-value:3.13E-37 ID:SGTC_317|Compound:4495-0002|FD-Score:3.31|P-value:9.04E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.21|P-value:4.35E-7 ID:SGTC_347|Compound:4534-1311|FD-Score:3.81|P-value:1.63E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.47|P-value:5.14E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.09|P-value:4.59E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:4.07|P-value:6.27E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:5.22|P-value:4.32E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.78|P-value:3.12E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:5.31|P-value:2.70E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.53|P-value:4.42E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.61|P-value:3.36E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.56|P-value:3.92E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.96|P-value:9.42E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.66|P-value:2.80E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.96|P-value:9.33E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.97|P-value:9.07E-9 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.37|P-value:7.50E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-6.17|P-value:2.64E-9 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.19|P-value:4.80E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.37|P-value:7.21E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.75|P-value:2.05E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.29|P-value:9.59E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.92|P-value:1.08E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-4.28|P-value:2.58E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.39|P-value:6.96E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:11.60|P-value:4.46E-28 ID:SGTC_1666|Compound:st014829|FD-Score:4.59|P-value:7.37E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:40.90|P-value:0 ID:SGTC_1722|Compound:st034304|FD-Score:4.71|P-value:4.36E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.41|P-value:1.68E-7 ID:SGTC_2016|Compound:5121758|FD-Score:3.54|P-value:4.24E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.24|P-value:3.19E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.40|P-value:6.81E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.32|P-value:8.63E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.88|P-value:1.21E-4 ID:SGTC_2363|Compound:9053361|FD-Score:12.10|P-value:1.21E-30 ID:SGTC_2367|Compound:9070478|FD-Score:4.85|P-value:2.36E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.98|P-value:8.82E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:4.01|P-value:7.74E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.67|P-value:5.34E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.00|P-value:1.18E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.95|P-value:9.41E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.03|P-value:7.22E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.49|P-value:4.99E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.24|P-value:3.02E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.71|P-value:2.31E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.02|P-value:7.61E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-3.95|P-value:9.48E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.99|P-value:1.19E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.93|P-value:1.04E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.95|P-value:9.22E-5 ID:SGTC_3149|Compound:9097855|FD-Score:22.60|P-value:5.88E-101 ID:SGTC_3152|Compound:9099253|FD-Score:-3.28|P-value:9.64E-4 ID:SGTC_3219|Compound:9131112|FD-Score:26.50|P-value:3.11E-138

Top fitness defect scores for YMR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1679 4130-1276 40.90 6.7 µM 0 Golgi 1 0 28.90
2 SGTC_3219 9131112 26.50 49.5 µM 3.11E-138 Golgi 1 1.00E-154 18.10
3 SGTC_3149 9097855 22.60 49.5 µM 5.88E-101 Golgi 1 6.08E-113 16.70
4 SGTC_291 4130-1278 13.40 35.5 µM 3.13E-37 Golgi 1 1.61E-41 4.48
5 SGTC_2363 9053361 12.10 176.0 µM 1.21E-30 Golgi 1 3.87E-34 3.79
6 SGTC_1581 himbacine 11.60 57.9 µM 4.46E-28 Golgi 1 2.91E-31 4.59
7 SGTC_467 ro 31-8220 6.09 72.8 µM 4.59E-9 calcium & mitochondrial duress 7 5.71E-10 0.54
8 SGTC_1083 didemethylchlorpromazine sulfoxide 5.97 707.4 nM 9.07E-9 redox potentiating 15 1.22E-9 0.12
9 SGTC_1844 rapamycin 5.41 4.0 nM 1.68E-7 28 3.20E-8 0.13
10 SGTC_576 1073-0113 5.31 22.7 µM 2.70E-7 redox potentiating 20 5.43E-8 0.01
11 SGTC_525 k781-2675 5.22 26.7 µM 4.32E-7 redox potentiating 30 9.17E-8 0.11
12 SGTC_327 1273-0057 5.21 4.0 µM 4.35E-7 azole & statin 3 9.25E-8 0.63
13 SGTC_1125 tnp00248 5.19 1.3 µM 4.80E-7 5 1.03E-7 0.61
14 SGTC_2567 aureobasidin a 5.00 60.0 nM 1.18E-6 25 2.84E-7 0.01
15 SGTC_2367 9070478 4.85 135.4 µM 2.36E-6 cell wall 5 6.11E-7 0.28
16 SGTC_1722 st034304 4.71 3.6 µM 4.36E-6 mitochondrial processes 8 1.22E-6 0.02
17 SGTC_2562 3',7'-dimethoxyflavone 4.67 64.9 µM 5.34E-6 7 1.53E-6 0.14
18 SGTC_1666 st014829 4.59 29.0 µM 7.37E-6 calcium & mitochondrial duress 4 2.19E-6 0.56
19 SGTC_2153 5569715 4.24 200.0 µM 3.19E-5 iron homeostasis 2 1.12E-5 0.38
20 SGTC_514 4466-0038 4.07 2.6 nM 6.27E-5 cell wall 38 2.39E-5 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.527 5.45E-239 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.282 1.26E-62 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.277 3.52E-60 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.257 7.47E-52 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.256 1.85E-51 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.255 9.04E-51 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.246 1.61E-47 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.230 1.43E-41 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.205 4.29E-33 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.203 1.09E-32 YDR451C YHP1 hom Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
0.199 3.15E-31 YGR289C MAL11 hom Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization
0.185 4.06E-27 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.164 1.05E-21 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.157 5.29E-20 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.148 6.78E-18 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport