HIPHOP chemogenomics database
YMR082C_d 
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YMR082C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.103 | 2.03E-9 | YMR315W | YMR315W | hom | Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress |
| 0.100 | 6.15E-9 | YLR120C | YPS1 | hom | Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor |
| 0.092 | 8.23E-8 | YER127W | LCP5 | het | Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus |
| 0.089 | 2.29E-7 | YBL100W-C_p | YBL100W-C_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.089 | 2.80E-7 | YCR050C_p | YCR050C_p | hom | Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein |
| 0.088 | 3.84E-7 | YFR030W | MET10 | hom | Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide |
| 0.086 | 6.10E-7 | YDR538W | PAD1 | hom | Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX |
| 0.085 | 9.03E-7 | YPL274W | SAM3 | hom | High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p |
| 0.081 | 2.72E-6 | YHR177W_p | YHR177W_p | hom | Putative protein of unknown function; overexpression causes a cell cycle delay or arrest |
| 0.080 | 3.45E-6 | YBL074C | AAR2 | het | Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron |
| 0.079 | 4.65E-6 | YBR229C | ROT2 | hom | Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations |
| 0.077 | 7.15E-6 | YHL016C | DUR3 | hom | Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway |
| 0.077 | 8.68E-6 | YLR152C_p | YLR152C_p | hom | Putative protein of unknown function; YLR152C is not an essential gene |
| 0.076 | 1.13E-5 | YKR043C | SHB17 | hom | Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus |
| 0.073 | 2.30E-5 | YPL168W_p | YPL168W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated |