YMR082C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR082C / YMR082C

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.78|P-value:1.43E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.40|P-value:5.45E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.45|P-value:1.24E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:3.63|P-value:2.93E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.98|P-value:8.35E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.79|P-value:1.69E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.30|P-value:2.45E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.52|P-value:9.32E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.65|P-value:5.13E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.05|P-value:8.44E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.32|P-value:7.17E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.26|P-value:2.71E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.63|P-value:2.93E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.48|P-value:5.05E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.72|P-value:2.16E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.39|P-value:6.80E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.72|P-value:2.13E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.62|P-value:3.06E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.45|P-value:5.50E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:7.85E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:4.22E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.29|P-value:2.38E-5 ID:SGTC_3023|Compound:9089636|FD-Score:3.30|P-value:8.92E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.90|P-value:9.11E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.44|P-value:5.73E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.22|P-value:9.87E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.78|P-value:1.43E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.40|P-value:5.45E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.45|P-value:1.24E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:3.63|P-value:2.93E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.98|P-value:8.35E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.79|P-value:1.69E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.30|P-value:2.45E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.52|P-value:9.32E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.65|P-value:5.13E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.05|P-value:8.44E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.32|P-value:7.17E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.26|P-value:2.71E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.63|P-value:2.93E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.48|P-value:5.05E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.72|P-value:2.16E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.39|P-value:6.80E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.72|P-value:2.13E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.62|P-value:3.06E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.45|P-value:5.50E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:7.85E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:4.22E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.29|P-value:2.38E-5 ID:SGTC_3023|Compound:9089636|FD-Score:3.30|P-value:8.92E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.90|P-value:9.11E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.44|P-value:5.73E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.22|P-value:9.87E-4

Top fitness defect scores for YMR082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1027 k015-0025 5.30 8.7 µM 2.45E-7 9 5.66E-8
2 SGTC_1206 3978-0017 5.05 132.0 µM 8.44E-7 ERG2 15 2.22E-7
3 SGTC_1197 1601-0112 4.65 267.0 µM 5.13E-6 5 1.62E-6
4 SGTC_1131 3454-3128 4.52 32.3 µM 9.32E-6 21 3.13E-6
5 SGTC_1018 4259-0013 4.49 28.1 µM 1.05E-5 9 3.57E-6
6 SGTC_121 0557-0495 4.45 61.3 µM 1.24E-5 calcium & mitochondrial duress 44 4.29E-6
7 SGTC_3015 9080845 4.29 49.5 µM 2.38E-5 5 8.81E-6
8 SGTC_1330 1469-0054 4.26 61.8 µM 2.71E-5 iron homeostasis 13 1.02E-5
9 SGTC_785 1270-0111 3.98 65.3 µM 8.35E-5 23 3.51E-5
10 SGTC_804 1595-0054 3.79 20.9 µM 1.69E-4 sphingolipid biosynthesis & PDR1 40 7.64E-5
11 SGTC_2604 4'-hydroxychalcone 3.72 11.3 µM 2.13E-4 45 9.86E-5
12 SGTC_2152 5568786 3.72 200.0 µM 2.16E-4 15 1.00E-4
13 SGTC_1423 4048-0112 3.63 5.6 µM 2.93E-4 32 1.40E-4
14 SGTC_750 4073-0104 3.63 132.0 µM 2.93E-4 16 1.40E-4
15 SGTC_2904 7225135 3.62 42.0 µM 3.06E-4 11 1.47E-4
16 SGTC_3013 9080133 3.53 71.4 µM 4.22E-4 37 2.09E-4
17 SGTC_2090 5301565 3.48 104.5 µM 5.05E-4 TSC3-RPN4 65 2.55E-4
18 SGTC_2940 9060638 3.45 45.9 µM 5.50E-4 amide catabolism 44 2.81E-4
19 SGTC_3201 9113999 3.44 49.5 µM 5.73E-4 55 2.93E-4
20 SGTC_2284 7945075 3.39 39.2 µM 6.80E-4 mitochondrial processes 47 3.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.03E-9 YMR315W YMR315W hom Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
0.100 6.15E-9 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.092 8.23E-8 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.089 2.29E-7 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.089 2.80E-7 YCR050C_p YCR050C_p hom Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
0.088 3.84E-7 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.086 6.10E-7 YDR538W PAD1 hom Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
0.085 9.03E-7 YPL274W SAM3 hom High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.081 2.72E-6 YHR177W_p YHR177W_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.080 3.45E-6 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.079 4.65E-6 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.077 7.15E-6 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.077 8.68E-6 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.076 1.13E-5 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.073 2.30E-5 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated