YMR083W / ADH3

Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR083W / ADH3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.02|P-value:1.10E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.70|P-value:2.59E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.48|P-value:5.10E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:6.06|P-value:5.60E-9 ID:SGTC_617|Compound:3770-0098|FD-Score:4.05|P-value:6.55E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:4.68|P-value:5.09E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.66|P-value:5.49E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.39|P-value:6.80E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.32|P-value:9.35E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.59|P-value:3.48E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.58|P-value:3.58E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.82|P-value:1.56E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.03|P-value:1.03E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.71|P-value:4.43E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.14|P-value:4.73E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.87|P-value:2.12E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.81|P-value:1.62E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.02|P-value:7.39E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.48|P-value:5.12E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.78|P-value:3.17E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.03|P-value:7.17E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.91|P-value:1.13E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.69|P-value:2.50E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.27|P-value:9.98E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.01|P-value:7.54E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-4.94|P-value:1.81E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.58|P-value:3.90E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.35|P-value:7.87E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.34|P-value:7.91E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.71|P-value:2.31E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.53|P-value:4.26E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.89|P-value:1.42E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:3.41|P-value:6.47E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.75|P-value:1.99E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.41|P-value:6.43E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.08|P-value:8.29E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.02|P-value:1.10E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.70|P-value:2.59E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.48|P-value:5.10E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:6.06|P-value:5.60E-9 ID:SGTC_617|Compound:3770-0098|FD-Score:4.05|P-value:6.55E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:4.68|P-value:5.09E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.66|P-value:5.49E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.39|P-value:6.80E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.32|P-value:9.35E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.59|P-value:3.48E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.58|P-value:3.58E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.82|P-value:1.56E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.03|P-value:1.03E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.71|P-value:4.43E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.14|P-value:4.73E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.87|P-value:2.12E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.81|P-value:1.62E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.02|P-value:7.39E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.48|P-value:5.12E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.78|P-value:3.17E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.03|P-value:7.17E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.91|P-value:1.13E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.69|P-value:2.50E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.27|P-value:9.98E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.01|P-value:7.54E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-4.94|P-value:1.81E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.58|P-value:3.90E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.35|P-value:7.87E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.34|P-value:7.91E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.71|P-value:2.31E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.53|P-value:4.26E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.89|P-value:1.42E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:3.41|P-value:6.47E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.75|P-value:1.99E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.41|P-value:6.43E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.08|P-value:8.29E-7

Top fitness defect scores for YMR083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_491 tetrandrine 6.06 80.3 µM 5.60E-9 1 6.94E-10
2 SGTC_2592 piperlongumine 5.89 83.3 µM 1.42E-8 TSC3-RPN4 7 1.98E-9
3 SGTC_3211 9128781 5.08 49.5 µM 8.29E-7 37 1.90E-7
4 SGTC_1221 2958-7315 5.03 257.0 µM 1.03E-6 7 2.43E-7
5 SGTC_45 0kpi-0036 5.02 14.9 µM 1.10E-6 excess fatty acid 8 2.61E-7
6 SGTC_1404 3909-7820 4.87 48.3 µM 2.12E-6 60S ribosome export 5 5.46E-7
7 SGTC_1676 st018489 4.78 23.4 µM 3.17E-6 60S ribosome export 16 8.55E-7
8 SGTC_1243 0416-0003 4.71 5.7 µM 4.43E-6 PDR1 12 1.25E-6
9 SGTC_629 3448-6466 4.68 76.7 µM 5.09E-6 7 1.46E-6
10 SGTC_800 3448-7362 4.66 155.0 µM 5.49E-6 translation 106 1.58E-6
11 SGTC_1379 2144-0755 4.14 36.5 µM 4.73E-5 18 1.77E-5
12 SGTC_617 3770-0098 4.05 35.0 µM 6.55E-5 exosome 13 2.54E-5
13 SGTC_1681 tripelennamine 4.03 100.0 µM 7.17E-5 19 2.82E-5
14 SGTC_1600 coumarin 106 4.02 71.1 µM 7.39E-5 24 2.92E-5
15 SGTC_1913 st060213 4.01 96.1 µM 7.54E-5 29 2.98E-5
16 SGTC_1730 st033808 3.91 45.1 µM 1.13E-4 31 4.69E-5
17 SGTC_1204 4049-0315 3.82 18.3 µM 1.56E-4 31 6.72E-5
18 SGTC_1500 4488-1866 3.81 171.0 µM 1.62E-4 RPP1 & pyrimidine depletion 22 7.00E-5
19 SGTC_2877 9040724 3.75 71.4 µM 1.99E-4 12 8.81E-5
20 SGTC_2268 7933382 3.71 153.8 µM 2.31E-4 43 1.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.67E-11 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.106 8.19E-10 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.096 3.05E-8 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.090 1.66E-7 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.085 8.55E-7 YER105C NUP157 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
0.082 2.20E-6 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.081 2.38E-6 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.081 2.66E-6 YNL012W SPO1 hom Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B
0.080 3.60E-6 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.076 1.07E-5 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.075 1.44E-5 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.075 1.53E-5 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.073 2.13E-5 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.072 3.40E-5 YGR090W UTP22 het Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
0.071 3.73E-5 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response