YMR084W_p

Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR084W / YMR084W

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-3.40|P-value:5.35E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.18|P-value:2.44E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.27|P-value:8.16E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.49|P-value:3.53E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.31|P-value:7.29E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:5.36|P-value:1.03E-7 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.36|P-value:6.03E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.24|P-value:8.17E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.62|P-value:2.22E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.22|P-value:8.74E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.29|P-value:7.07E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.54|P-value:2.91E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.22|P-value:2.14E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.56|P-value:4.73E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.31|P-value:1.31E-7 ID:SGTC_1814|Compound:st052110|FD-Score:3.65|P-value:1.97E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.23|P-value:9.30E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.18|P-value:2.84E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.20|P-value:9.43E-4 ID:SGTC_1956|Compound:st077085|FD-Score:5.10|P-value:3.70E-7 ID:SGTC_2020|Compound:4017018|FD-Score:4.23|P-value:2.06E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.63|P-value:2.37E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:10.70|P-value:1.76E-25 ID:SGTC_2171|Compound:5739187|FD-Score:-3.72|P-value:1.68E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.26|P-value:7.81E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.57|P-value:2.89E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.22|P-value:9.83E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.17|P-value:2.61E-7 ID:SGTC_2186|Compound:6124449|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_2219|Compound:9098279|FD-Score:4.62|P-value:3.63E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-3.38|P-value:5.70E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.23|P-value:9.50E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.42|P-value:4.92E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.31|P-value:6.40E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.63|P-value:2.09E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.92|P-value:1.03E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.68|P-value:1.76E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.24|P-value:8.18E-4 ID:SGTC_2976|Compound:9009005|FD-Score:5.65|P-value:2.11E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.88|P-value:9.15E-5 ID:SGTC_3027|Compound:9089541|FD-Score:-3.90|P-value:8.54E-5 ID:SGTC_3029|Compound:9088683|FD-Score:6.88|P-value:1.33E-11 ID:SGTC_3058|Compound:9093861|FD-Score:-4.68|P-value:3.20E-6 ID:SGTC_3068|Compound:9116768|FD-Score:3.69|P-value:1.68E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.29|P-value:6.99E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.86|P-value:9.02E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.63|P-value:2.14E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.36|P-value:5.57E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.54|P-value:2.94E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.81|P-value:1.21E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.77|P-value:1.23E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.23|P-value:8.39E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-4.00|P-value:5.70E-5 ID:SGTC_3333|Compound:9141820|FD-Score:6.33|P-value:4.27E-10 ID:SGTC_3354|Compound:9151612|FD-Score:-3.35|P-value:6.23E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:-3.40|P-value:5.35E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.18|P-value:2.44E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.27|P-value:8.16E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.49|P-value:3.53E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.31|P-value:7.29E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:5.36|P-value:1.03E-7 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.36|P-value:6.03E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.24|P-value:8.17E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.62|P-value:2.22E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.22|P-value:8.74E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.29|P-value:7.07E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.54|P-value:2.91E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.22|P-value:2.14E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.56|P-value:4.73E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:5.31|P-value:1.31E-7 ID:SGTC_1814|Compound:st052110|FD-Score:3.65|P-value:1.97E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.23|P-value:9.30E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.18|P-value:2.84E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.20|P-value:9.43E-4 ID:SGTC_1956|Compound:st077085|FD-Score:5.10|P-value:3.70E-7 ID:SGTC_2020|Compound:4017018|FD-Score:4.23|P-value:2.06E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.63|P-value:2.37E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:10.70|P-value:1.76E-25 ID:SGTC_2171|Compound:5739187|FD-Score:-3.72|P-value:1.68E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.26|P-value:7.81E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.57|P-value:2.89E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.22|P-value:9.83E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.17|P-value:2.61E-7 ID:SGTC_2186|Compound:6124449|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_2219|Compound:9098279|FD-Score:4.62|P-value:3.63E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-3.38|P-value:5.70E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.23|P-value:9.50E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.42|P-value:4.92E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.31|P-value:6.40E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.63|P-value:2.09E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.92|P-value:1.03E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.68|P-value:1.76E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.24|P-value:8.18E-4 ID:SGTC_2976|Compound:9009005|FD-Score:5.65|P-value:2.11E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.88|P-value:9.15E-5 ID:SGTC_3027|Compound:9089541|FD-Score:-3.90|P-value:8.54E-5 ID:SGTC_3029|Compound:9088683|FD-Score:6.88|P-value:1.33E-11 ID:SGTC_3058|Compound:9093861|FD-Score:-4.68|P-value:3.20E-6 ID:SGTC_3068|Compound:9116768|FD-Score:3.69|P-value:1.68E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.29|P-value:6.99E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.86|P-value:9.02E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.63|P-value:2.14E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.36|P-value:5.57E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.54|P-value:2.94E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.81|P-value:1.21E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.77|P-value:1.23E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.23|P-value:8.39E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.83|P-value:1.01E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-4.00|P-value:5.70E-5 ID:SGTC_3333|Compound:9141820|FD-Score:6.33|P-value:4.27E-10 ID:SGTC_3354|Compound:9151612|FD-Score:-3.35|P-value:6.23E-4

Top fitness defect scores for YMR084W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2170 morpholine 10.70 200.0 µM 1.76E-25 1 4.90E-27
2 SGTC_3029 9088683 6.88 49.5 µM 1.33E-11 1 3.09E-12
3 SGTC_3333 9141820 6.33 12.1 µM 4.27E-10 1 1.24E-10
4 SGTC_2976 9009005 5.65 19.5 µM 2.11E-8 14 7.92E-9
5 SGTC_577 r071-0003 5.36 38.6 µM 1.03E-7 fatty acid desaturase (OLE1) 22 4.28E-8
6 SGTC_1575 cyproterone acetate 5.31 48.0 µM 1.31E-7 5 5.51E-8
7 SGTC_2184 6075246 5.17 200.0 µM 2.61E-7 10 1.15E-7
8 SGTC_1956 st077085 5.10 54.0 µM 3.70E-7 6 1.67E-7
9 SGTC_2219 9098279 4.62 200.0 µM 3.63E-6 1 1.89E-6
10 SGTC_1387 3342-1166 4.56 1.8 µM 4.73E-6 mitochondrial processes 8 2.51E-6
11 SGTC_2020 4017018 4.23 200.0 µM 2.06E-5 12 1.19E-5
12 SGTC_1352 1496-0991 4.22 99.0 µM 2.14E-5 tubulin folding & SWR complex 27 1.25E-5
13 SGTC_60 0986-0278 4.18 202.0 µM 2.44E-5 11 1.43E-5
14 SGTC_3131 9127911 3.86 49.5 µM 9.02E-5 32 5.74E-5
15 SGTC_3323 9138564 3.83 53.9 µM 1.01E-4 26 6.46E-5
16 SGTC_2038 4100038 3.83 31.0 µM 1.01E-4 plasma membrane duress 56 6.47E-5
17 SGTC_3253 9135987 3.77 49.5 µM 1.23E-4 60S ribosome export 16 8.01E-5
18 SGTC_3068 9116768 3.69 49.5 µM 1.68E-4 23 1.11E-4
19 SGTC_2774 tamoxifen 3.68 10.9 µM 1.76E-4 19 1.17E-4
20 SGTC_1814 st052110 3.65 31.5 µM 1.97E-4 RNA processing & uracil transport 16 1.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 8.15E-9 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.089 2.36E-7 YPR109W_p YPR109W_p hom Predicted membrane protein; dipoid deletion strain has high budding index
0.081 2.36E-6 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.081 2.88E-6 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.080 3.87E-6 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.079 4.20E-6 YFL054C_p YFL054C_p hom Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
0.074 1.81E-5 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.074 1.79E-5 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.070 4.71E-5 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.068 7.50E-5 YBR009C HHF1 hom Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
0.068 8.08E-5 YBL075C SSA3 hom ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication
0.065 1.56E-4 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.065 1.59E-4 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.063 2.33E-4 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.063 2.45E-4 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions