YMR086C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR086C-A / YMR086C-A

Click on Significant Values for Screen Details ID:SGTC_352|Compound:k048-0007|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.08|P-value:7.98E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.67|P-value:8.53E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.89|P-value:3.39E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.14|P-value:6.55E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.50|P-value:1.56E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-4.35|P-value:3.68E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.04|P-value:1.61E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:4.18|P-value:9.21E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:4.32|P-value:4.61E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.10|P-value:1.31E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.65|P-value:9.29E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.50|P-value:1.69E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.77|P-value:5.56E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.28|P-value:3.81E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.52|P-value:1.51E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.14|P-value:6.55E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.61|P-value:4.30E-9 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.17|P-value:5.78E-4 ID:SGTC_1779|Compound:st039427|FD-Score:7.03|P-value:2.61E-13 ID:SGTC_2021|Compound:4019055|FD-Score:3.18|P-value:5.67E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.03|P-value:9.65E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.09|P-value:7.80E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.55|P-value:1.27E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.02|P-value:1.74E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-4.09|P-value:1.28E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.20|P-value:8.35E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.03|P-value:9.07E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.61|P-value:1.12E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.39|P-value:2.51E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.06|P-value:8.43E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.59|P-value:4.95E-9 ID:SGTC_2952|Compound:9073731|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.20|P-value:8.22E-6 ID:SGTC_2963|Compound:9082507|FD-Score:4.12|P-value:1.17E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.69|P-value:7.72E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.19|P-value:5.45E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.47|P-value:1.85E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.90|P-value:3.19E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.35|P-value:2.96E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-3.87|P-value:3.32E-5 ID:SGTC_3129|Compound:9127257|FD-Score:4.65|P-value:9.03E-7 ID:SGTC_3142|Compound:9086498|FD-Score:3.46|P-value:1.96E-4 ID:SGTC_3150|Compound:9097574|FD-Score:7.26|P-value:4.73E-14 ID:SGTC_3289|Compound:9119912|FD-Score:3.73|P-value:6.56E-5 ID:SGTC_3295|Compound:9122362|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.08|P-value:7.98E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.67|P-value:8.53E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.89|P-value:3.39E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.14|P-value:6.55E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.50|P-value:1.56E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-4.35|P-value:3.68E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.04|P-value:1.61E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:4.18|P-value:9.21E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:4.32|P-value:4.61E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.10|P-value:1.31E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.65|P-value:9.29E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.50|P-value:1.69E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.77|P-value:5.56E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.28|P-value:3.81E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.52|P-value:1.51E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.14|P-value:6.55E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.61|P-value:4.30E-9 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.17|P-value:5.78E-4 ID:SGTC_1779|Compound:st039427|FD-Score:7.03|P-value:2.61E-13 ID:SGTC_2021|Compound:4019055|FD-Score:3.18|P-value:5.67E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.03|P-value:9.65E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.09|P-value:7.80E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.55|P-value:1.27E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.02|P-value:1.74E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-4.09|P-value:1.28E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.20|P-value:8.35E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.03|P-value:9.07E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.61|P-value:1.12E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.39|P-value:2.51E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.06|P-value:8.43E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.59|P-value:4.95E-9 ID:SGTC_2952|Compound:9073731|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.20|P-value:8.22E-6 ID:SGTC_2963|Compound:9082507|FD-Score:4.12|P-value:1.17E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.69|P-value:7.72E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.19|P-value:5.45E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.47|P-value:1.85E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.90|P-value:3.19E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.35|P-value:2.96E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-3.87|P-value:3.32E-5 ID:SGTC_3129|Compound:9127257|FD-Score:4.65|P-value:9.03E-7 ID:SGTC_3142|Compound:9086498|FD-Score:3.46|P-value:1.96E-4 ID:SGTC_3150|Compound:9097574|FD-Score:7.26|P-value:4.73E-14 ID:SGTC_3289|Compound:9119912|FD-Score:3.73|P-value:6.56E-5 ID:SGTC_3295|Compound:9122362|FD-Score:3.55|P-value:1.38E-4

Top fitness defect scores for YMR086C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3150 9097574 7.26 49.5 µM 4.73E-14 1 1.99E-13
2 SGTC_1779 st039427 7.03 55.0 µM 2.61E-13 1 1.01E-12
3 SGTC_1564 D-Arginine 5.61 115.0 µM 4.30E-9 11 1.01E-8
4 SGTC_2927 9011802 5.59 47.9 µM 4.95E-9 7 1.16E-8
5 SGTC_3129 9127257 4.65 49.5 µM 9.03E-7 10 1.63E-6
6 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.61 100.0 µM 1.12E-6 14 1.99E-6
7 SGTC_993 3909-8757 4.32 62.7 µM 4.61E-6 18 7.66E-6
8 SGTC_2960 9079389 4.20 6.0 µM 8.22E-6 23 1.33E-5
9 SGTC_2408 sulbentine 4.20 18.4 µM 8.35E-6 42 1.35E-5
10 SGTC_893 0958-0369 4.18 48.9 µM 9.21E-6 20 1.48E-5
11 SGTC_2963 9082507 4.12 9.0 µM 1.17E-5 23 1.86E-5
12 SGTC_1041 0206-0046 4.10 107.0 µM 1.31E-5 33 2.07E-5
13 SGTC_3108 9121785 3.90 49.5 µM 3.19E-5 13 4.83E-5
14 SGTC_626 0214-0009 3.89 33.0 µM 3.39E-5 copper-dependent oxidative stress 22 5.11E-5
15 SGTC_1285 0929-0069 3.77 65.5 µM 5.56E-5 21 8.18E-5
16 SGTC_3289 9119912 3.73 71.4 µM 6.56E-5 22 9.58E-5
17 SGTC_2999 9069765 3.69 71.4 µM 7.72E-5 amide catabolism 38 1.12E-4
18 SGTC_537 1334-0398 3.67 209.0 µM 8.53E-5 35 1.23E-4
19 SGTC_1043 0916-0009 3.65 19.3 µM 9.29E-5 32 1.33E-4
20 SGTC_637 1181-0519 3.60 7.3 µM 1.10E-4 fatty acid desaturase (OLE1) 123 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.23E-8 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.090 1.77E-7 YMR175W SIP18 hom Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress
0.082 2.25E-6 YOL093W TRM10 hom tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress
0.081 2.85E-6 YPR028W YOP1 hom Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress
0.081 2.98E-6 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.077 7.23E-6 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.077 7.48E-6 YGR181W TIM13 hom Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.077 8.59E-6 YPL021W ECM23 hom Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
0.076 1.02E-5 YBR060C ORC2 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
0.076 1.09E-5 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.072 2.88E-5 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.071 4.19E-5 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.071 4.30E-5 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
0.068 8.86E-5 YCL050C APA1 hom AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
0.067 1.14E-4 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane