YMR087W

Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR087W / YMR087W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.94|P-value:3.46E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:4.97|P-value:2.60E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.34|P-value:3.57E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.16|P-value:1.33E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.54|P-value:1.78E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.47|P-value:3.25E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.73|P-value:8.49E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.93|P-value:3.66E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:7.00|P-value:7.66E-13 ID:SGTC_817|Compound:1391-0715|FD-Score:4.19|P-value:1.17E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.74|P-value:7.96E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.19|P-value:6.36E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.26|P-value:4.94E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.71|P-value:8.87E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.64|P-value:1.38E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:6.11|P-value:3.33E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:3.82|P-value:5.73E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.21|P-value:1.06E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:6.09|P-value:3.96E-10 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.14|P-value:7.29E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.61|P-value:1.32E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.64|P-value:1.21E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.13|P-value:7.91E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.38|P-value:3.25E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.96|P-value:3.18E-5 ID:SGTC_1763|Compound:st044482|FD-Score:4.87|P-value:4.49E-7 ID:SGTC_1994|Compound:st072947|FD-Score:4.08|P-value:1.88E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.20|P-value:1.10E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.49|P-value:2.18E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.72|P-value:8.54E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.09|P-value:9.10E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.20|P-value:6.19E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.83|P-value:5.52E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:3.23|P-value:5.56E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.10|P-value:8.69E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.71|P-value:9.16E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-3.06|P-value:9.85E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.10|P-value:8.80E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.15|P-value:7.44E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.39|P-value:3.12E-4 ID:SGTC_2932|Compound:9016711|FD-Score:7.28|P-value:9.52E-14 ID:SGTC_3033|Compound:9090887|FD-Score:3.07|P-value:9.76E-4 ID:SGTC_3056|Compound:9094900|FD-Score:5.12|P-value:1.14E-7 ID:SGTC_3110|Compound:9122132|FD-Score:-3.54|P-value:1.69E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.08|P-value:9.54E-4 ID:SGTC_3113|Compound:9123498|FD-Score:4.81|P-value:5.82E-7 ID:SGTC_3245|Compound:9134821|FD-Score:3.75|P-value:7.59E-5 ID:SGTC_3253|Compound:9135987|FD-Score:4.74|P-value:8.63E-7 ID:SGTC_35|Compound:0133-0054|FD-Score:3.94|P-value:3.46E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:4.97|P-value:2.60E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.34|P-value:3.57E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.16|P-value:1.33E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.54|P-value:1.78E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.47|P-value:3.25E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.73|P-value:8.49E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.93|P-value:3.66E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:7.00|P-value:7.66E-13 ID:SGTC_817|Compound:1391-0715|FD-Score:4.19|P-value:1.17E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.74|P-value:7.96E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.19|P-value:6.36E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.26|P-value:4.94E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.71|P-value:8.87E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.64|P-value:1.38E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:6.11|P-value:3.33E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:3.82|P-value:5.73E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.21|P-value:1.06E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:6.09|P-value:3.96E-10 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.14|P-value:7.29E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.61|P-value:1.32E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.64|P-value:1.21E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.13|P-value:7.91E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.38|P-value:3.25E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.96|P-value:3.18E-5 ID:SGTC_1763|Compound:st044482|FD-Score:4.87|P-value:4.49E-7 ID:SGTC_1994|Compound:st072947|FD-Score:4.08|P-value:1.88E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.20|P-value:1.10E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.49|P-value:2.18E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.72|P-value:8.54E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.09|P-value:9.10E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.20|P-value:6.19E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.83|P-value:5.52E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:3.23|P-value:5.56E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.10|P-value:8.69E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.71|P-value:9.16E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-3.06|P-value:9.85E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.10|P-value:8.80E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.15|P-value:7.44E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.39|P-value:3.12E-4 ID:SGTC_2932|Compound:9016711|FD-Score:7.28|P-value:9.52E-14 ID:SGTC_3033|Compound:9090887|FD-Score:3.07|P-value:9.76E-4 ID:SGTC_3056|Compound:9094900|FD-Score:5.12|P-value:1.14E-7 ID:SGTC_3110|Compound:9122132|FD-Score:-3.54|P-value:1.69E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.08|P-value:9.54E-4 ID:SGTC_3113|Compound:9123498|FD-Score:4.81|P-value:5.82E-7 ID:SGTC_3245|Compound:9134821|FD-Score:3.75|P-value:7.59E-5 ID:SGTC_3253|Compound:9135987|FD-Score:4.74|P-value:8.63E-7

Top fitness defect scores for YMR087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2932 9016711 7.28 44.5 µM 9.52E-14 9 1.65E-13
2 SGTC_746 1095-0025 7.00 46.6 µM 7.66E-13 RSC & ERG11 3 1.27E-12
3 SGTC_992 3909-8734 6.11 162.0 µM 3.33E-10 2 4.88E-10
4 SGTC_1121 fusaric acid 6.09 630.5 nM 3.96E-10 9 5.78E-10
5 SGTC_3056 9094900 5.12 49.5 µM 1.14E-7 5 1.49E-7
6 SGTC_44 0929-0055 4.97 61.2 µM 2.60E-7 17 3.34E-7
7 SGTC_1763 st044482 4.87 94.5 µM 4.49E-7 copper-dependent oxidative stress 13 5.71E-7
8 SGTC_3113 9123498 4.81 49.5 µM 5.82E-7 5 7.37E-7
9 SGTC_3253 9135987 4.74 49.5 µM 8.63E-7 60S ribosome export 5 1.08E-6
10 SGTC_918 glabranin 4.64 770.7 nM 1.38E-6 18 1.72E-6
11 SGTC_457 grayanotoxin iii 4.47 135.0 µM 3.25E-6 45 3.97E-6
12 SGTC_1100 amiodarone 4.21 5.1 µM 1.06E-5 12 1.27E-5
13 SGTC_2102 5377816 4.20 72.8 µM 1.10E-5 22 1.32E-5
14 SGTC_817 1391-0715 4.19 46.0 µM 1.17E-5 13 1.40E-5
15 SGTC_125 0133-0007 4.16 11.8 µM 1.33E-5 DNA intercalators 4 1.58E-5
16 SGTC_1994 st072947 4.08 40.9 µM 1.88E-5 12 2.22E-5
17 SGTC_1636 st007707 3.96 68.9 µM 3.18E-5 49 3.72E-5
18 SGTC_35 0133-0054 3.94 64.1 µM 3.46E-5 34 4.05E-5
19 SGTC_656 4090-1979 3.93 187.0 µM 3.66E-5 18 4.27E-5
20 SGTC_2667 digitoxin 3.83 100.0 µM 5.52E-5 3 6.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.30E-13 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.127 1.48E-13 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.122 1.31E-12 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.115 2.59E-11 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.112 7.33E-11 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.101 5.35E-9 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.091 1.27E-7 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.089 2.16E-7 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.085 7.09E-7 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.084 1.02E-6 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.078 5.44E-6 YNR038W DBP6 het Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
0.078 6.14E-6 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.073 2.20E-5 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.073 2.55E-5 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.072 3.18E-5 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy