YMR088C / VBA1

Permease of basic amino acids in the vacuolar membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR088C / VBA1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-4.24|P-value:7.29E-6 ID:SGTC_292|Compound:k038-0015|FD-Score:3.78|P-value:5.92E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.25|P-value:4.43E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.36|P-value:4.40E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.75|P-value:6.17E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:-3.69|P-value:8.08E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.05|P-value:1.85E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.80|P-value:4.53E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.38|P-value:2.69E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.19|P-value:5.50E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.14|P-value:6.64E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.15|P-value:6.59E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.69|P-value:8.60E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.29|P-value:3.96E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.28|P-value:4.09E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.43|P-value:2.40E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.30|P-value:3.93E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.06|P-value:1.61E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.37|P-value:2.99E-4 ID:SGTC_2693|Compound:st077581|FD-Score:5.00|P-value:1.75E-7 ID:SGTC_2865|Compound:9030313|FD-Score:-3.48|P-value:1.82E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.04|P-value:1.88E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.07|P-value:8.95E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.08|P-value:8.56E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.94|P-value:2.98E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.96|P-value:2.68E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.26|P-value:4.49E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.08|P-value:7.96E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.12|P-value:7.39E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.17|P-value:5.84E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.05|P-value:8.90E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.84|P-value:4.60E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.04|P-value:9.70E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.34|P-value:3.33E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.11|P-value:7.23E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.24|P-value:7.29E-6 ID:SGTC_292|Compound:k038-0015|FD-Score:3.78|P-value:5.92E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.25|P-value:4.43E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.36|P-value:4.40E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.75|P-value:6.17E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:-3.69|P-value:8.08E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.05|P-value:1.85E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.80|P-value:4.53E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.38|P-value:2.69E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.19|P-value:5.50E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.14|P-value:6.64E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.15|P-value:6.59E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.69|P-value:8.60E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.29|P-value:3.96E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.28|P-value:4.09E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.43|P-value:2.40E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.30|P-value:3.93E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.06|P-value:1.61E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.37|P-value:2.99E-4 ID:SGTC_2693|Compound:st077581|FD-Score:5.00|P-value:1.75E-7 ID:SGTC_2865|Compound:9030313|FD-Score:-3.48|P-value:1.82E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.04|P-value:1.88E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.07|P-value:8.95E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.08|P-value:8.56E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.94|P-value:2.98E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.96|P-value:2.68E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.26|P-value:4.49E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.08|P-value:7.96E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.12|P-value:7.39E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.17|P-value:5.84E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.05|P-value:8.90E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.84|P-value:4.60E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.04|P-value:9.70E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.34|P-value:3.33E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.11|P-value:7.23E-4

Top fitness defect scores for YMR088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2693 st077581 5.00 40.7 µM 1.75E-7 14 2.93E-7
2 SGTC_451 chloral hydrate 4.36 100.0 µM 4.40E-6 37 6.52E-6
3 SGTC_815 1582-0027 4.05 36.9 µM 1.85E-5 22 2.60E-5
4 SGTC_2876 9059903 4.04 26.0 µM 1.88E-5 9 2.63E-5
5 SGTC_3145 9085516 3.96 49.5 µM 2.68E-5 fatty acid desaturase (OLE1) 30 3.71E-5
6 SGTC_3089 9117425 3.94 49.5 µM 2.98E-5 19 4.10E-5
7 SGTC_3251 9135047 3.84 49.5 µM 4.60E-5 60S ribosome export 4 6.23E-5
8 SGTC_292 k038-0015 3.78 474.0 µM 5.92E-5 8 7.94E-5
9 SGTC_2107 5363541 3.69 170.2 µM 8.60E-5 12 1.14E-4
10 SGTC_2608 thymoquinone 3.61 42.7 µM 1.16E-4 27 1.52E-4
11 SGTC_814 3342-0569 3.56 96.0 µM 1.42E-4 28 1.85E-4
12 SGTC_2419 paclitaxel 3.43 166.5 µM 2.40E-4 75 3.06E-4
13 SGTC_2634 4'-methoxyflavone 3.37 100.0 µM 2.99E-4 55 3.78E-4
14 SGTC_3288 9119690 3.34 36.2 µM 3.33E-4 30 4.19E-4
15 SGTC_2433 5607874 3.30 27.8 µM 3.93E-4 46 4.92E-4
16 SGTC_2116 5511452 3.29 16.9 µM 3.96E-4 36 4.96E-4
17 SGTC_2121 5257820 3.28 149.6 µM 4.09E-4 24 5.11E-4
18 SGTC_3155 9099265 3.26 49.5 µM 4.49E-4 51 5.59E-4
19 SGTC_2404 5161160 3.20 200.0 µM 5.64E-4 42 6.97E-4
20 SGTC_1576 erythromycin ethylsuccinate 3.15 23.2 µM 6.59E-4 50 8.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.299 4.64E-68 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.201 1.22E-31 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.181 1.10E-25 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.156 2.07E-19 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.142 2.00E-16 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.119 5.01E-12 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.115 3.16E-11 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.108 4.46E-10 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.098 1.70E-8 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.097 1.94E-8 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.095 4.10E-8 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.093 9.27E-8 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.092 1.20E-7 YNL065W AQR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.092 1.24E-7 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.091 1.50E-7 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth