YMR090W_p

Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR090W / YMR090W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-4.02|P-value:5.53E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:5.97|P-value:5.47E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.96|P-value:7.00E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.24|P-value:2.52E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.27|P-value:8.11E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.05|P-value:6.67E-7 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.34|P-value:6.59E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-4.61|P-value:4.68E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:6.68|P-value:8.14E-11 ID:SGTC_869|Compound:0564-0080|FD-Score:4.36|P-value:1.54E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:6.32|P-value:7.35E-10 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.64|P-value:2.27E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.40|P-value:1.31E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.56|P-value:3.35E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.31|P-value:1.89E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:6.69|P-value:7.33E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.34|P-value:7.14E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.40|P-value:1.30E-5 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.39|P-value:6.00E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.95|P-value:8.00E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.59|P-value:3.03E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.61|P-value:2.78E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.17|P-value:3.28E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.68|P-value:3.77E-6 ID:SGTC_2024|Compound:5144227|FD-Score:-3.96|P-value:6.97E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-5.32|P-value:1.60E-7 ID:SGTC_2260|Compound:7964312|FD-Score:-3.46|P-value:4.32E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.43|P-value:4.81E-4 ID:SGTC_2464|Compound:5717415|FD-Score:4.65|P-value:4.30E-6 ID:SGTC_2473|Compound:5854593|FD-Score:4.09|P-value:4.55E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.48|P-value:4.41E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:8.27|P-value:1.16E-15 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.58|P-value:3.14E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.44|P-value:1.08E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.25|P-value:8.80E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.93|P-value:1.19E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.25|P-value:9.63E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.48|P-value:4.47E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.66|P-value:2.34E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.61|P-value:2.84E-4 ID:SGTC_2966|Compound:9084041|FD-Score:4.06|P-value:5.15E-5 ID:SGTC_3015|Compound:9080845|FD-Score:-4.34|P-value:1.47E-5 ID:SGTC_3074|Compound:9116018|FD-Score:4.91|P-value:1.35E-6 ID:SGTC_3304|Compound:9125678|FD-Score:4.68|P-value:3.71E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.02|P-value:5.53E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:5.97|P-value:5.47E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.96|P-value:7.00E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.24|P-value:2.52E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.27|P-value:8.11E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.05|P-value:6.67E-7 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.34|P-value:6.59E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-4.61|P-value:4.68E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:6.68|P-value:8.14E-11 ID:SGTC_869|Compound:0564-0080|FD-Score:4.36|P-value:1.54E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:6.32|P-value:7.35E-10 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.64|P-value:2.27E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.40|P-value:1.31E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.56|P-value:3.35E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.31|P-value:1.89E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:6.69|P-value:7.33E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.34|P-value:7.14E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.40|P-value:1.30E-5 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.39|P-value:6.00E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.95|P-value:8.00E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.59|P-value:3.03E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.61|P-value:2.78E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.17|P-value:3.28E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.68|P-value:3.77E-6 ID:SGTC_2024|Compound:5144227|FD-Score:-3.96|P-value:6.97E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-5.32|P-value:1.60E-7 ID:SGTC_2260|Compound:7964312|FD-Score:-3.46|P-value:4.32E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.43|P-value:4.81E-4 ID:SGTC_2464|Compound:5717415|FD-Score:4.65|P-value:4.30E-6 ID:SGTC_2473|Compound:5854593|FD-Score:4.09|P-value:4.55E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.48|P-value:4.41E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:8.27|P-value:1.16E-15 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.58|P-value:3.14E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.44|P-value:1.08E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.25|P-value:8.80E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.93|P-value:1.19E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.25|P-value:9.63E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.48|P-value:4.47E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.66|P-value:2.34E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.61|P-value:2.84E-4 ID:SGTC_2966|Compound:9084041|FD-Score:4.06|P-value:5.15E-5 ID:SGTC_3015|Compound:9080845|FD-Score:-4.34|P-value:1.47E-5 ID:SGTC_3074|Compound:9116018|FD-Score:4.91|P-value:1.35E-6 ID:SGTC_3304|Compound:9125678|FD-Score:4.68|P-value:3.71E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.63|P-value:2.57E-4

Top fitness defect scores for YMR090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2596 sinensetin 8.27 100.0 µM 1.16E-15 2 6.52E-17
2 SGTC_1275 0867-0008 6.69 21.1 µM 7.33E-11 1 1.08E-11
3 SGTC_750 4073-0104 6.68 132.0 µM 8.14E-11 1 1.21E-11
4 SGTC_872 0588-0139 6.32 234.0 µM 7.35E-10 6 1.33E-10
5 SGTC_44 0929-0055 5.97 61.2 µM 5.47E-9 8 1.17E-9
6 SGTC_513 4245-1575 5.05 41.7 µM 6.67E-7 unfolded protein response 71 2.18E-7
7 SGTC_2755 lomerizine 4.93 42.7 µM 1.19E-6 12 4.08E-7
8 SGTC_3074 9116018 4.91 49.5 µM 1.35E-6 RNA processing & uracil transport 8 4.67E-7
9 SGTC_3304 9125678 4.68 46.1 µM 3.71E-6 28 1.40E-6
10 SGTC_2021 4019055 4.68 173.0 µM 3.77E-6 endomembrane recycling 78 1.43E-6
11 SGTC_2464 5717415 4.65 7.7 µM 4.30E-6 4 1.65E-6
12 SGTC_2603 homopterocarpin 4.44 100.0 µM 1.08E-5 18 4.50E-6
13 SGTC_1357 1503-1303 4.40 39.5 µM 1.30E-5 19 5.45E-6
14 SGTC_1031 k035-0009 4.40 16.0 µM 1.31E-5 15 5.53E-6
15 SGTC_869 0564-0080 4.36 44.1 µM 1.54E-5 16 6.58E-6
16 SGTC_1264 0783-0040 4.31 158.0 µM 1.89E-5 17 8.22E-6
17 SGTC_444 curcumin 4.24 90.4 µM 2.52E-5 iron homeostasis 20 1.12E-5
18 SGTC_1845 st056753 4.17 3.0 µM 3.28E-5 TSC3-RPN4 31 1.50E-5
19 SGTC_2473 5854593 4.09 8.9 µM 4.55E-5 8 2.14E-5
20 SGTC_2966 9084041 4.06 48.0 µM 5.15E-5 30 2.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.05E-15 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.101 3.87E-9 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.101 5.04E-9 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.094 4.29E-8 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.093 5.74E-8 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.089 2.13E-7 YLR083C EMP70 hom Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments
0.089 2.80E-7 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.088 3.65E-7 YMR068W AVO2 hom Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.080 3.11E-6 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.080 3.84E-6 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.079 4.22E-6 YCL047C POF1 hom ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p
0.078 6.74E-6 YOR332W VMA4 hom Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress
0.077 8.70E-6 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
0.077 8.88E-6 YHR060W VMA22 hom Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
0.076 1.01E-5 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus