YMR093W / UTP15

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR093W / UTP15

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.52|P-value:9.37E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.19|P-value:7.96E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.71|P-value:5.25E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.47|P-value:3.77E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.45|P-value:4.06E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-4.36|P-value:4.23E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.58|P-value:6.11E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.73|P-value:3.81E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-4.23|P-value:6.81E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.69|P-value:5.51E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.26|P-value:6.11E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.54|P-value:8.94E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.79|P-value:5.08E-10 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.63|P-value:6.69E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.51|P-value:7.53E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.98|P-value:2.19E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.61|P-value:2.27E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.67|P-value:4.50E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.38|P-value:3.92E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.13|P-value:9.65E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:5.63|P-value:2.94E-7 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.43|P-value:3.20E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.76|P-value:4.51E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.51|P-value:9.76E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.56|P-value:1.94E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.92|P-value:2.61E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.51|P-value:9.68E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.90|P-value:2.83E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.69|P-value:4.25E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.00|P-value:1.54E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.67|P-value:6.02E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.50|P-value:2.51E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.55|P-value:8.53E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.06|P-value:1.23E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.61|P-value:7.08E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.73|P-value:1.40E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.64|P-value:2.83E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-3.62|P-value:5.32E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-5.38|P-value:6.49E-7 ID:SGTC_1733|Compound:st037357|FD-Score:-4.35|P-value:4.38E-5 ID:SGTC_1768|Compound:st044301|FD-Score:4.43|P-value:4.36E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-8.24|P-value:6.86E-14 ID:SGTC_1829|Compound:berberine|FD-Score:-4.14|P-value:9.37E-5 ID:SGTC_2100|Compound:5377183|FD-Score:-3.95|P-value:1.83E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.06|P-value:1.23E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.75|P-value:4.59E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.21|P-value:9.78E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.54|P-value:8.91E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.61|P-value:7.22E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.42|P-value:9.98E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.89|P-value:2.91E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-5.43|P-value:5.10E-7 ID:SGTC_2511|Compound:berberine|FD-Score:-4.97|P-value:3.86E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.42|P-value:3.37E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.07|P-value:1.19E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.31|P-value:8.64E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.67|P-value:5.93E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-4.40|P-value:3.56E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-4.45|P-value:3.02E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.94|P-value:2.48E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.58|P-value:1.84E-5 ID:SGTC_2812|Compound:7970281|FD-Score:5.75|P-value:1.66E-7 ID:SGTC_3032|Compound:9089427|FD-Score:-4.88|P-value:5.56E-6 ID:SGTC_3353|Compound:9151644|FD-Score:-3.45|P-value:9.16E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.52|P-value:9.37E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.19|P-value:7.96E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.71|P-value:5.25E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.47|P-value:3.77E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.45|P-value:4.06E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-4.36|P-value:4.23E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.58|P-value:6.11E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.73|P-value:3.81E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-4.23|P-value:6.81E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.69|P-value:5.51E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.26|P-value:6.11E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.54|P-value:8.94E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.79|P-value:5.08E-10 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.63|P-value:6.69E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.51|P-value:7.53E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.98|P-value:2.19E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.61|P-value:2.27E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.67|P-value:4.50E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.38|P-value:3.92E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.13|P-value:9.65E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:5.63|P-value:2.94E-7 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.43|P-value:3.20E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.76|P-value:4.51E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.51|P-value:9.76E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.56|P-value:1.94E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.92|P-value:2.61E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.51|P-value:9.68E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.90|P-value:2.83E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.69|P-value:4.25E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.00|P-value:1.54E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.67|P-value:6.02E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.50|P-value:2.51E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.55|P-value:8.53E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.06|P-value:1.23E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.61|P-value:7.08E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.73|P-value:1.40E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.64|P-value:2.83E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-3.62|P-value:5.32E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-5.38|P-value:6.49E-7 ID:SGTC_1733|Compound:st037357|FD-Score:-4.35|P-value:4.38E-5 ID:SGTC_1768|Compound:st044301|FD-Score:4.43|P-value:4.36E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-8.24|P-value:6.86E-14 ID:SGTC_1829|Compound:berberine|FD-Score:-4.14|P-value:9.37E-5 ID:SGTC_2100|Compound:5377183|FD-Score:-3.95|P-value:1.83E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.06|P-value:1.23E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.75|P-value:4.59E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.21|P-value:9.78E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.54|P-value:8.91E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.61|P-value:7.22E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.42|P-value:9.98E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.89|P-value:2.91E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-5.43|P-value:5.10E-7 ID:SGTC_2511|Compound:berberine|FD-Score:-4.97|P-value:3.86E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.42|P-value:3.37E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.07|P-value:1.19E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.31|P-value:8.64E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.67|P-value:5.93E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-4.40|P-value:3.56E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-4.45|P-value:3.02E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.94|P-value:2.48E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.58|P-value:1.84E-5 ID:SGTC_2812|Compound:7970281|FD-Score:5.75|P-value:1.66E-7 ID:SGTC_3032|Compound:9089427|FD-Score:-4.88|P-value:5.56E-6 ID:SGTC_3353|Compound:9151644|FD-Score:-3.45|P-value:9.16E-4

Top fitness defect scores for YMR093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2812 7970281 5.75 58.4 µM 1.66E-7 3 4.34E-9 0.90
2 SGTC_1712 st032288 5.64 53.4 µM 2.83E-7 calcium & mitochondrial duress 14 8.45E-9 0.13
3 SGTC_1096 rimcazole 5.63 32.2 µM 2.94E-7 1 8.87E-9 1.81
4 SGTC_1631 benzylvanillin 4.73 81.9 µM 1.40E-5 Golgi 2 1.12E-6 0.30
5 SGTC_718 1130-0073 4.61 349.0 µM 2.27E-5 3 2.05E-6 0.41
6 SGTC_118 0083-0097 4.47 135.3 µM 3.77E-5 translation 13 3.87E-6 0.22
7 SGTC_120 rhodamine 6G 4.45 52.3 µM 4.06E-5 mitochondrial processes 14 4.24E-6 0.07
8 SGTC_1768 st044301 4.43 37.2 µM 4.36E-5 3 4.64E-6 0.12
9 SGTC_2277 7947813 4.21 106.9 µM 9.78E-5 RSC complex & mRNA processing 15 1.27E-5 0.06
10 SGTC_712 r015-0009 3.98 80.6 µM 2.19E-4 5 3.49E-5 0.01
11 SGTC_2768 sulfasalazine 3.94 50.2 µM 2.48E-4 10 4.07E-5 0.06
12 SGTC_1304 1165-0502 3.92 251.0 µM 2.61E-4 7 4.34E-5 0.05
13 SGTC_1339 1486-1321 3.90 22.7 µM 2.83E-4 ERG2 7 4.81E-5 0.24
14 SGTC_2445 5742597 3.89 35.6 µM 2.91E-4 8 4.98E-5 0.35
15 SGTC_1222 0366-0074 3.76 1.2 µM 4.51E-4 TSC3-RPN4 5 8.61E-5 0.32
16 SGTC_2156 5649887 3.75 115.0 µM 4.59E-4 RPP1 & pyrimidine depletion 18 8.80E-5 0.10
17 SGTC_114 0364-0001 3.71 490.3 µM 5.25E-4 4 1.04E-4 0.01
18 SGTC_250 brefeldin a 3.69 552.2 µM 5.51E-4 PDR1 1 1.11E-4 0.23
19 SGTC_2679 rapamycin 3.67 1.0 nM 5.93E-4 56 1.21E-4 0.04
20 SGTC_1456 k015-0012 3.67 13.0 µM 6.02E-4 9 1.23E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 4.55E-24 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.162 4.44E-21 YHR196W UTP9 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.158 3.14E-20 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.146 2.44E-17 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.140 3.86E-16 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.130 3.62E-14 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.122 1.51E-12 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.117 1.14E-11 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.116 1.61E-11 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.116 1.74E-11 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.113 6.96E-11 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.111 1.25E-10 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.108 3.48E-10 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.107 5.20E-10 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.105 1.13E-9 YOR210W RPB10 het RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III