YMR098C / ATP25

Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR098C / ATP25

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.91|P-value:1.90E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.91|P-value:1.87E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.63|P-value:4.74E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:6.36|P-value:3.58E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:5.52|P-value:2.60E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.99|P-value:1.39E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.81|P-value:5.88E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.60|P-value:2.33E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:19.50|P-value:6.57E-71 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.50|P-value:7.48E-26 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:4.43E-23 ID:SGTC_365|Compound:0121-0052|FD-Score:3.48|P-value:7.83E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.14|P-value:1.45E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.34|P-value:3.88E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.85|P-value:2.31E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.45|P-value:8.61E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.58|P-value:1.51E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.53|P-value:6.54E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.94|P-value:1.38E-10 ID:SGTC_832|Compound:4083-0019|FD-Score:4.42|P-value:2.93E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.90|P-value:1.97E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.24|P-value:9.32E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:9.30|P-value:1.33E-17 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.31|P-value:6.69E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.84|P-value:2.37E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.44|P-value:3.67E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.33|P-value:3.96E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.67|P-value:4.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.03|P-value:1.23E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.33|P-value:4.06E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.15|P-value:8.08E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.68|P-value:4.01E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.79|P-value:2.81E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.42|P-value:9.29E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.54|P-value:6.40E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.68|P-value:4.01E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.55|P-value:1.77E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.87|P-value:2.12E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.45|P-value:3.57E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.98|P-value:1.43E-4 ID:SGTC_1742|Compound:st038235|FD-Score:10.70|P-value:1.21E-22 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.30|P-value:6.93E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-4.61|P-value:1.36E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.53|P-value:1.82E-5 ID:SGTC_1825|Compound:st052143|FD-Score:3.75|P-value:3.24E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.34|P-value:3.86E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.71|P-value:3.65E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.79|P-value:2.77E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.43|P-value:2.71E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.27|P-value:5.15E-5 ID:SGTC_2139|Compound:5578692|FD-Score:5.16|P-value:1.33E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.71|P-value:1.02E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-6.62|P-value:8.32E-10 ID:SGTC_2337|Compound:9009472|FD-Score:4.19|P-value:6.89E-5 ID:SGTC_2361|Compound:9034121|FD-Score:5.12|P-value:1.56E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.79|P-value:2.83E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.11|P-value:9.08E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-4.12|P-value:8.83E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.09|P-value:9.80E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.90|P-value:1.92E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.76|P-value:3.07E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.43|P-value:9.03E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:6.27|P-value:5.80E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:3.92|P-value:1.82E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.08|P-value:1.00E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.99|P-value:1.43E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.08|P-value:1.01E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:7.68E-5 ID:SGTC_3010|Compound:9080089|FD-Score:-5.35|P-value:5.48E-7 ID:SGTC_3011|Compound:9081274|FD-Score:-3.43|P-value:8.81E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.60|P-value:5.15E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.61|P-value:5.04E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-4.24|P-value:5.61E-5 ID:SGTC_3207|Compound:9114163|FD-Score:5.93|P-value:3.35E-8 ID:SGTC_3210|Compound:9128157|FD-Score:4.81|P-value:5.94E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:3.91|P-value:1.90E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.91|P-value:1.87E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.63|P-value:4.74E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:6.36|P-value:3.58E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:5.52|P-value:2.60E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.99|P-value:1.39E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.81|P-value:5.88E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.60|P-value:2.33E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:19.50|P-value:6.57E-71 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.50|P-value:7.48E-26 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:4.43E-23 ID:SGTC_365|Compound:0121-0052|FD-Score:3.48|P-value:7.83E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.14|P-value:1.45E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.34|P-value:3.88E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.85|P-value:2.31E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.45|P-value:8.61E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.58|P-value:1.51E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.53|P-value:6.54E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.94|P-value:1.38E-10 ID:SGTC_832|Compound:4083-0019|FD-Score:4.42|P-value:2.93E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.90|P-value:1.97E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.24|P-value:9.32E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:9.30|P-value:1.33E-17 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.31|P-value:6.69E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.84|P-value:2.37E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.44|P-value:3.67E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.33|P-value:3.96E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.67|P-value:4.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.03|P-value:1.23E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.33|P-value:4.06E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.15|P-value:8.08E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.68|P-value:4.01E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.79|P-value:2.81E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.42|P-value:9.29E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.54|P-value:6.40E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.68|P-value:4.01E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.55|P-value:1.77E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.87|P-value:2.12E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.45|P-value:3.57E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.98|P-value:1.43E-4 ID:SGTC_1742|Compound:st038235|FD-Score:10.70|P-value:1.21E-22 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.30|P-value:6.93E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-4.61|P-value:1.36E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.53|P-value:1.82E-5 ID:SGTC_1825|Compound:st052143|FD-Score:3.75|P-value:3.24E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.34|P-value:3.86E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.71|P-value:3.65E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.79|P-value:2.77E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.43|P-value:2.71E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-4.27|P-value:5.15E-5 ID:SGTC_2139|Compound:5578692|FD-Score:5.16|P-value:1.33E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.71|P-value:1.02E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-6.62|P-value:8.32E-10 ID:SGTC_2337|Compound:9009472|FD-Score:4.19|P-value:6.89E-5 ID:SGTC_2361|Compound:9034121|FD-Score:5.12|P-value:1.56E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.79|P-value:2.83E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.11|P-value:9.08E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-4.12|P-value:8.83E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.09|P-value:9.80E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.90|P-value:1.92E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.76|P-value:3.07E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.43|P-value:9.03E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:6.27|P-value:5.80E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:3.92|P-value:1.82E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.08|P-value:1.00E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.99|P-value:1.43E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.08|P-value:1.01E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:7.68E-5 ID:SGTC_3010|Compound:9080089|FD-Score:-5.35|P-value:5.48E-7 ID:SGTC_3011|Compound:9081274|FD-Score:-3.43|P-value:8.81E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.60|P-value:5.15E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.61|P-value:5.04E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-4.24|P-value:5.61E-5 ID:SGTC_3207|Compound:9114163|FD-Score:5.93|P-value:3.35E-8 ID:SGTC_3210|Compound:9128157|FD-Score:4.81|P-value:5.94E-6

Top fitness defect scores for YMR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 19.50 5.3 µM 6.57E-71 60 3.67E-85
2 SGTC_275 trichlorophene 11.50 5.7 µM 7.48E-26 mitochondrial stress 28 8.21E-31
3 SGTC_310 1273-0058 10.80 1.1 µM 4.43E-23 mitochondrial stress 33 1.81E-27
4 SGTC_1742 st038235 10.70 28.9 µM 1.21E-22 mitochondrial stress 8 6.05E-27
5 SGTC_908 3448-7491 9.30 47.7 µM 1.33E-17 mitochondrial stress 10 7.19E-21
6 SGTC_173 1273-0061 7.60 2.7 µM 2.33E-12 mitochondrial stress 77 1.48E-14
7 SGTC_778 3456-2434 6.94 196.0 µM 1.38E-10 mitochondrial response to ROS 15 2.02E-12
8 SGTC_116 0155-0182 6.36 31.8 µM 3.58E-9 mitochondrial response to ROS 19 1.01E-10
9 SGTC_2749 bexarotene 6.27 57.4 µM 5.80E-9 3 1.80E-10
10 SGTC_3207 9114163 5.93 49.5 µM 3.35E-8 8 1.48E-9
11 SGTC_2250 alverine citrate 5.71 130.0 µM 1.02E-7 61 5.67E-9
12 SGTC_119 0121-0043 5.52 24.8 µM 2.60E-7 mitochondrial stress 32 1.73E-8
13 SGTC_1635 st007035 5.45 42.4 µM 3.57E-7 149 2.54E-8
14 SGTC_1007 4101-0031 5.44 70.0 µM 3.67E-7 5 2.62E-8
15 SGTC_892 0929-0076 5.24 29.0 µM 9.32E-7 TRP & mitochondrial translation 14 8.03E-8
16 SGTC_2139 5578692 5.16 56.5 µM 1.33E-6 superoxide 8 1.24E-7
17 SGTC_386 1509-0011 5.14 3.1 µM 1.45E-6 103 1.36E-7
18 SGTC_2361 9034121 5.12 116.0 µM 1.56E-6 RSC complex & mRNA processing 5 1.49E-7
19 SGTC_3210 9128157 4.81 49.5 µM 5.94E-6 26 7.40E-7
20 SGTC_1621 st003705 4.55 32.4 µM 1.77E-5 calcium & mitochondrial duress 12 2.74E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.582 2.94E-302 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.559 5.65E-275 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.553 1.57E-267 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.550 1.63E-264 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.547 2.69E-260 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.543 1.49E-255 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.533 3.65E-245 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.529 8.48E-241 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.515 1.03E-226 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.507 8.03E-217 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.506 1.40E-217 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.503 4.17E-214 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.486 3.33E-198 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.480 4.51E-192 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.479 3.07E-191 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit