YMR099C

Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR099C / YMR099C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:7.57|P-value:4.74E-13 ID:SGTC_13|Compound:0199-0087|FD-Score:3.66|P-value:2.91E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.98|P-value:9.07E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:6.48|P-value:5.01E-10 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.38|P-value:9.20E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:6.17|P-value:3.04E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:4.68|P-value:5.32E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:5.49|P-value:1.18E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:8.19|P-value:5.90E-15 ID:SGTC_181|Compound:1447-1644|FD-Score:3.36|P-value:7.94E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.40|P-value:6.95E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.29|P-value:2.76E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.26|P-value:9.80E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:7.65|P-value:2.67E-13 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.53|P-value:8.40E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.63|P-value:3.27E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.29|P-value:3.22E-7 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:5.79|P-value:2.51E-8 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.55|P-value:4.28E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.58|P-value:3.85E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:8.20|P-value:5.12E-15 ID:SGTC_518|Compound:1021-0119|FD-Score:7.79|P-value:1.01E-13 ID:SGTC_543|Compound:3844-1095|FD-Score:7.92|P-value:4.06E-14 ID:SGTC_562|Compound:3772-2733|FD-Score:9.17|P-value:2.67E-18 ID:SGTC_582|Compound:0987-0078|FD-Score:5.51|P-value:1.06E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:4.24|P-value:3.35E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.92|P-value:1.14E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.51|P-value:9.27E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.37|P-value:7.69E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.56|P-value:8.15E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.92|P-value:9.78E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.30|P-value:9.67E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.50|P-value:1.15E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:5.81|P-value:2.20E-8 ID:SGTC_1211|Compound:1056-0033|FD-Score:5.11|P-value:7.39E-7 ID:SGTC_1304|Compound:1165-0502|FD-Score:10.40|P-value:5.65E-23 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.39|P-value:1.57E-12 ID:SGTC_1712|Compound:st032288|FD-Score:8.07|P-value:1.41E-14 ID:SGTC_1741|Compound:st038134|FD-Score:-3.45|P-value:5.15E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.92|P-value:9.81E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.76|P-value:3.13E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.83|P-value:1.57E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-4.10|P-value:4.94E-5 ID:SGTC_1937|Compound:st074714|FD-Score:4.04|P-value:7.29E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.33|P-value:2.26E-5 ID:SGTC_2144|Compound:5628481|FD-Score:9.81|P-value:1.08E-20 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.07|P-value:5.46E-9 ID:SGTC_2322|Compound:7413319|FD-Score:11.10|P-value:5.76E-26 ID:SGTC_2430|Compound:5571206|FD-Score:-3.62|P-value:2.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:17.30|P-value:2.23E-60 ID:SGTC_2692|Compound:st077426|FD-Score:-3.60|P-value:3.14E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.65|P-value:2.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.01|P-value:8.20E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.93|P-value:1.09E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.83|P-value:6.05E-11 ID:SGTC_2956|Compound:9076196|FD-Score:5.23|P-value:4.28E-7 ID:SGTC_2961|Compound:9083290|FD-Score:3.63|P-value:3.21E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.62|P-value:6.83E-6 ID:SGTC_3303|Compound:9125618|FD-Score:3.96|P-value:9.73E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.53|P-value:1.02E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:7.57|P-value:4.74E-13 ID:SGTC_13|Compound:0199-0087|FD-Score:3.66|P-value:2.91E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.98|P-value:9.07E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:6.48|P-value:5.01E-10 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.38|P-value:9.20E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:6.17|P-value:3.04E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:4.68|P-value:5.32E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:5.49|P-value:1.18E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:8.19|P-value:5.90E-15 ID:SGTC_181|Compound:1447-1644|FD-Score:3.36|P-value:7.94E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.40|P-value:6.95E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.29|P-value:2.76E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.26|P-value:9.80E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:7.65|P-value:2.67E-13 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.53|P-value:8.40E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.63|P-value:3.27E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.29|P-value:3.22E-7 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:5.79|P-value:2.51E-8 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.55|P-value:4.28E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.58|P-value:3.85E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:8.20|P-value:5.12E-15 ID:SGTC_518|Compound:1021-0119|FD-Score:7.79|P-value:1.01E-13 ID:SGTC_543|Compound:3844-1095|FD-Score:7.92|P-value:4.06E-14 ID:SGTC_562|Compound:3772-2733|FD-Score:9.17|P-value:2.67E-18 ID:SGTC_582|Compound:0987-0078|FD-Score:5.51|P-value:1.06E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:4.24|P-value:3.35E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.92|P-value:1.14E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.51|P-value:9.27E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.37|P-value:7.69E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.56|P-value:8.15E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.92|P-value:9.78E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.30|P-value:9.67E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.50|P-value:1.15E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:5.81|P-value:2.20E-8 ID:SGTC_1211|Compound:1056-0033|FD-Score:5.11|P-value:7.39E-7 ID:SGTC_1304|Compound:1165-0502|FD-Score:10.40|P-value:5.65E-23 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.39|P-value:1.57E-12 ID:SGTC_1712|Compound:st032288|FD-Score:8.07|P-value:1.41E-14 ID:SGTC_1741|Compound:st038134|FD-Score:-3.45|P-value:5.15E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.92|P-value:9.81E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.76|P-value:3.13E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.83|P-value:1.57E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-4.10|P-value:4.94E-5 ID:SGTC_1937|Compound:st074714|FD-Score:4.04|P-value:7.29E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.33|P-value:2.26E-5 ID:SGTC_2144|Compound:5628481|FD-Score:9.81|P-value:1.08E-20 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.07|P-value:5.46E-9 ID:SGTC_2322|Compound:7413319|FD-Score:11.10|P-value:5.76E-26 ID:SGTC_2430|Compound:5571206|FD-Score:-3.62|P-value:2.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:17.30|P-value:2.23E-60 ID:SGTC_2692|Compound:st077426|FD-Score:-3.60|P-value:3.14E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.65|P-value:2.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.01|P-value:8.20E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.93|P-value:1.09E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.83|P-value:6.05E-11 ID:SGTC_2956|Compound:9076196|FD-Score:5.23|P-value:4.28E-7 ID:SGTC_2961|Compound:9083290|FD-Score:3.63|P-value:3.21E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.62|P-value:6.83E-6 ID:SGTC_3303|Compound:9125618|FD-Score:3.96|P-value:9.73E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.53|P-value:1.02E-5

Top fitness defect scores for YMR099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 17.30 96.7 µM 2.23E-60 calcium & mitochondrial duress 4 1.80E-67
2 SGTC_2322 7413319 11.10 38.2 µM 5.76E-26 ERAD & cell cycle 13 6.33E-29
3 SGTC_1304 1165-0502 10.40 251.0 µM 5.65E-23 8 1.42E-25
4 SGTC_2144 5628481 9.81 200.0 µM 1.08E-20 ERG2 3 5.13E-23
5 SGTC_562 3772-2733 9.17 112.0 µM 2.67E-18 ERG2 12 2.45E-20
6 SGTC_515 4092-1064 8.20 102.0 µM 5.12E-15 plasma membrane duress 17 1.16E-16
7 SGTC_178 4092-0806 8.19 87.5 µM 5.90E-15 ergosterol depletion effects on membrane 19 1.36E-16
8 SGTC_1712 st032288 8.07 53.4 µM 1.41E-14 calcium & mitochondrial duress 45 3.62E-16
9 SGTC_543 3844-1095 7.92 191.0 µM 4.06E-14 ERG2 8 1.18E-15
10 SGTC_518 1021-0119 7.79 62.6 µM 1.01E-13 ERG2 4 3.29E-15
11 SGTC_308 4092-1169 7.65 104.0 µM 2.67E-13 plasma membrane duress 8 9.72E-15
12 SGTC_8 0354-0001 7.57 70.0 µM 4.74E-13 12 1.85E-14
13 SGTC_1597 7-benzyloxygramine 7.39 47.5 µM 1.57E-12 calcium & mitochondrial duress 30 7.08E-14
14 SGTC_2896 9052656 6.83 71.4 µM 6.05E-11 endomembrane recycling 28 4.23E-12
15 SGTC_86 0417-1630 6.48 471.9 µM 5.01E-10 ubiquinone biosynthesis & proteasome 82 4.50E-11
16 SGTC_102 gallobenzophenone 6.38 83.6 µM 9.20E-10 redox potentiating 10 8.90E-11
17 SGTC_142 0335-0849 6.17 62.7 µM 3.04E-9 ubiquinone biosynthesis & proteasome 60 3.40E-10
18 SGTC_2249 haloperidol 6.07 116.4 µM 5.46E-9 ergosterol depletion effects on membrane 45 6.54E-10
19 SGTC_1209 2323-2347 5.81 50.3 µM 2.20E-8 2 3.11E-9
20 SGTC_473 2-arachidonoylglycerol 5.79 10.0 µM 2.51E-8 4 3.60E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 5.00E-81 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.284 2.49E-63 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.266 1.20E-55 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.257 8.68E-52 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.245 3.63E-47 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.240 2.75E-45 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.238 1.87E-44 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.237 7.33E-44 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.234 3.65E-43 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.230 2.16E-41 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.219 1.15E-37 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.207 1.24E-33 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.203 1.33E-32 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.198 7.17E-31 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.198 7.36E-31 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication