YMR101C / SRT1

Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR101C / SRT1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:2.83|P-value:8.92E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:-4.15|P-value:2.50E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.45|P-value:7.61E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:-2.86|P-value:8.50E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.04|P-value:4.25E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.84|P-value:8.56E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.51|P-value:5.69E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.87|P-value:8.08E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.63|P-value:3.19E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.06|P-value:3.97E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.02|P-value:4.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.22|P-value:1.93E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.92|P-value:6.71E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.30|P-value:1.35E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.21|P-value:2.00E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.26|P-value:1.60E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-2.82|P-value:9.90E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.08|P-value:3.37E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.33|P-value:1.28E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-2.92|P-value:6.78E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.29|P-value:1.17E-6 ID:SGTC_1676|Compound:st018489|FD-Score:5.87|P-value:4.92E-11 ID:SGTC_1825|Compound:st052143|FD-Score:3.03|P-value:4.14E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-2.85|P-value:8.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.69|P-value:2.34E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.11|P-value:3.05E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.99|P-value:5.79E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.87|P-value:8.13E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.11|P-value:2.99E-6 ID:SGTC_2849|Compound:9019321|FD-Score:3.18|P-value:2.27E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-2.85|P-value:8.63E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.28|P-value:1.59E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.06|P-value:3.69E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:2.83|P-value:8.92E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:-4.15|P-value:2.50E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.45|P-value:7.61E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:-2.86|P-value:8.50E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.04|P-value:4.25E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.84|P-value:8.56E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.51|P-value:5.69E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.87|P-value:8.08E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.63|P-value:3.19E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.06|P-value:3.97E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.02|P-value:4.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.22|P-value:1.93E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.92|P-value:6.71E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.30|P-value:1.35E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.21|P-value:2.00E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.26|P-value:1.60E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-2.82|P-value:9.90E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.08|P-value:3.37E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.33|P-value:1.28E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-2.92|P-value:6.78E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.29|P-value:1.17E-6 ID:SGTC_1676|Compound:st018489|FD-Score:5.87|P-value:4.92E-11 ID:SGTC_1825|Compound:st052143|FD-Score:3.03|P-value:4.14E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-2.85|P-value:8.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.69|P-value:2.34E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.11|P-value:3.05E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.99|P-value:5.79E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.87|P-value:8.13E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.11|P-value:2.99E-6 ID:SGTC_2849|Compound:9019321|FD-Score:3.18|P-value:2.27E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-2.85|P-value:8.63E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.28|P-value:1.59E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.06|P-value:3.69E-4

Top fitness defect scores for YMR101C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1676 st018489 5.87 23.4 µM 4.92E-11 60S ribosome export 6 2.14E-9
2 SGTC_1673 st016611 4.29 27.3 µM 1.17E-6 34 9.12E-6
3 SGTC_2758 dehydroepiandrosterone 4.11 69.3 µM 2.99E-6 34 2.00E-5
4 SGTC_2395 5646831 3.69 180.2 µM 2.34E-5 31 1.10E-4
5 SGTC_769 0302-0231 3.63 76.0 µM 3.19E-5 53 1.43E-4
6 SGTC_1132 3456-3614 3.30 2.5 µM 1.35E-4 tubulin folding & SWR complex 88 4.77E-4
7 SGTC_979 1426-2828 3.27 121.0 µM 1.59E-4 46 5.46E-4
8 SGTC_1383 3049-0032 3.26 20.7 µM 1.60E-4 60S ribosome export 41 5.49E-4
9 SGTC_916 4466-0038 3.22 42.0 nM 1.93E-4 cell wall 115 6.42E-4
10 SGTC_1258 0671-0043 3.21 57.1 µM 2.00E-4 60 6.61E-4
11 SGTC_972 1319-0219 3.19 195.0 µM 2.14E-4 60 6.99E-4
12 SGTC_2849 9019321 3.18 13.0 µM 2.27E-4 59 7.35E-4
13 SGTC_2397 5161689 3.11 200.0 µM 3.05E-4 75 9.41E-4
14 SGTC_1465 k213-0056 3.08 144.0 µM 3.37E-4 DNA intercalators 54 0.00102
15 SGTC_3345 9148410 3.06 3.6 µM 3.69E-4 28 0.00110
16 SGTC_1825 st052143 3.03 62.6 µM 4.14E-4 42 0.00121
17 SGTC_912 3474-0017 3.02 2.2 µM 4.30E-4 63 0.00125
18 SGTC_323 4013-0906 2.84 34.3 µM 8.56E-4 ERG2 49 0.00223
19 SGTC_73 0327-0325 2.83 16.2 µM 8.92E-4 DNA damage response 141 0.00231
20 SGTC_940 3232-1287 2.73 54.8 µM 0.00130 NEO1 105 0.00316

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 3.25E-26 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.170 3.87E-23 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.164 1.55E-21 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.158 3.36E-20 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.153 6.24E-19 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.144 5.55E-17 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.135 4.65E-15 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.134 7.51E-15 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.132 2.14E-14 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.131 2.67E-14 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.123 7.70E-13 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.122 1.47E-12 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.122 1.56E-12 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.118 6.29E-12 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.117 1.00E-11 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR