YMR102C_p

Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR102C / YMR102C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.49|P-value:1.89E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:5.61|P-value:5.14E-9 ID:SGTC_90|Compound:0870-0863|FD-Score:5.87|P-value:1.05E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:3.70|P-value:7.61E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:5.06|P-value:1.16E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:3.39|P-value:2.49E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.84|P-value:3.90E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.63|P-value:1.46E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:37.20|P-value:0 ID:SGTC_340|Compound:k038-0059|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.46|P-value:2.78E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.10|P-value:7.25E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.37|P-value:2.68E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.64|P-value:9.43E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:8.35|P-value:9.93E-18 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.14|P-value:6.20E-17 ID:SGTC_459|Compound:nigericin|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.76|P-value:2.10E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-6.51|P-value:3.31E-11 ID:SGTC_470|Compound:aa-861|FD-Score:10.70|P-value:4.65E-28 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.08|P-value:7.80E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:12.30|P-value:7.14E-36 ID:SGTC_543|Compound:3844-1095|FD-Score:10.10|P-value:3.24E-25 ID:SGTC_548|Compound:1436-0017|FD-Score:5.41|P-value:1.69E-8 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.73|P-value:1.11E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:4.69|P-value:8.24E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:8.97|P-value:3.71E-20 ID:SGTC_635|Compound:k038-0028|FD-Score:5.72|P-value:2.73E-9 ID:SGTC_639|Compound:0833-0042|FD-Score:3.93|P-value:2.90E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:5.61|P-value:5.34E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:3.97|P-value:2.42E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:7.35|P-value:3.75E-14 ID:SGTC_767|Compound:0929-0023|FD-Score:3.60|P-value:1.12E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.08|P-value:2.76E-13 ID:SGTC_819|Compound:1013-0258|FD-Score:3.74|P-value:6.22E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:6.15|P-value:1.76E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:3.61|P-value:1.07E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:12.20|P-value:1.00E-35 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.09|P-value:7.37E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.98|P-value:2.27E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.09|P-value:2.23E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:42.30|P-value:0 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.21|P-value:7.04E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.35|P-value:6.90E-6 ID:SGTC_1613|Compound:st002381|FD-Score:-3.18|P-value:7.81E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.70|P-value:7.37E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-4.55|P-value:2.65E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-4.99|P-value:3.00E-7 ID:SGTC_1766|Compound:st045414|FD-Score:3.47|P-value:1.84E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.20|P-value:5.08E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.10|P-value:7.35E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.28|P-value:3.77E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.22|P-value:9.75E-14 ID:SGTC_1924|Compound:st058459|FD-Score:4.28|P-value:5.87E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_1941|Compound:st076221|FD-Score:15.30|P-value:2.02E-54 ID:SGTC_2015|Compound:5119600|FD-Score:-3.36|P-value:4.03E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.77|P-value:5.38E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-4.15|P-value:1.69E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.19|P-value:5.31E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.36|P-value:2.77E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.83|P-value:4.35E-5 ID:SGTC_2482|Compound:5981709|FD-Score:7.18|P-value:1.28E-13 ID:SGTC_2488|Compound:5268135|FD-Score:3.52|P-value:1.55E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.06|P-value:8.44E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.56|P-value:1.31E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.71|P-value:4.18E-12 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.30|P-value:4.94E-31 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.14|P-value:8.94E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.76|P-value:5.84E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.72|P-value:7.05E-7 ID:SGTC_2788|Compound:5282734|FD-Score:3.68|P-value:8.25E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-5.24|P-value:7.75E-8 ID:SGTC_2798|Compound:7813637|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.25|P-value:6.07E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.60|P-value:1.11E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-3.13|P-value:9.30E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.38|P-value:1.95E-8 ID:SGTC_3125|Compound:9127534|FD-Score:4.32|P-value:4.96E-6 ID:SGTC_3143|Compound:9086658|FD-Score:3.25|P-value:4.26E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.74|P-value:6.41E-7 ID:SGTC_3153|Compound:9100258|FD-Score:3.39|P-value:2.50E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.84|P-value:6.23E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.98|P-value:2.34E-5 ID:SGTC_3297|Compound:9117502|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_3311|Compound:9131146|FD-Score:9.61|P-value:7.87E-23 ID:SGTC_3312|Compound:9133330|FD-Score:-4.87|P-value:5.53E-7 ID:SGTC_3323|Compound:9138564|FD-Score:3.68|P-value:8.16E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-3.21|P-value:6.94E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.38|P-value:2.57E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.49|P-value:1.89E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:5.61|P-value:5.14E-9 ID:SGTC_90|Compound:0870-0863|FD-Score:5.87|P-value:1.05E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:3.70|P-value:7.61E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:5.06|P-value:1.16E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:3.39|P-value:2.49E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.84|P-value:3.90E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.63|P-value:1.46E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:37.20|P-value:0 ID:SGTC_340|Compound:k038-0059|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.46|P-value:2.78E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.10|P-value:7.25E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.37|P-value:2.68E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.64|P-value:9.43E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:8.35|P-value:9.93E-18 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.14|P-value:6.20E-17 ID:SGTC_459|Compound:nigericin|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.76|P-value:2.10E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-6.51|P-value:3.31E-11 ID:SGTC_470|Compound:aa-861|FD-Score:10.70|P-value:4.65E-28 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.08|P-value:7.80E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:12.30|P-value:7.14E-36 ID:SGTC_543|Compound:3844-1095|FD-Score:10.10|P-value:3.24E-25 ID:SGTC_548|Compound:1436-0017|FD-Score:5.41|P-value:1.69E-8 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.73|P-value:1.11E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:4.69|P-value:8.24E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:8.97|P-value:3.71E-20 ID:SGTC_635|Compound:k038-0028|FD-Score:5.72|P-value:2.73E-9 ID:SGTC_639|Compound:0833-0042|FD-Score:3.93|P-value:2.90E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:5.61|P-value:5.34E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:3.97|P-value:2.42E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:7.35|P-value:3.75E-14 ID:SGTC_767|Compound:0929-0023|FD-Score:3.60|P-value:1.12E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.08|P-value:2.76E-13 ID:SGTC_819|Compound:1013-0258|FD-Score:3.74|P-value:6.22E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:6.15|P-value:1.76E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:3.61|P-value:1.07E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:12.20|P-value:1.00E-35 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.09|P-value:7.37E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.98|P-value:2.27E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.09|P-value:2.23E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:42.30|P-value:0 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.21|P-value:7.04E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.35|P-value:6.90E-6 ID:SGTC_1613|Compound:st002381|FD-Score:-3.18|P-value:7.81E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.70|P-value:7.37E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-4.55|P-value:2.65E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-4.99|P-value:3.00E-7 ID:SGTC_1766|Compound:st045414|FD-Score:3.47|P-value:1.84E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.20|P-value:5.08E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.10|P-value:7.35E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.28|P-value:3.77E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.22|P-value:9.75E-14 ID:SGTC_1924|Compound:st058459|FD-Score:4.28|P-value:5.87E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_1941|Compound:st076221|FD-Score:15.30|P-value:2.02E-54 ID:SGTC_2015|Compound:5119600|FD-Score:-3.36|P-value:4.03E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.77|P-value:5.38E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-4.15|P-value:1.69E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.19|P-value:5.31E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.36|P-value:2.77E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.83|P-value:4.35E-5 ID:SGTC_2482|Compound:5981709|FD-Score:7.18|P-value:1.28E-13 ID:SGTC_2488|Compound:5268135|FD-Score:3.52|P-value:1.55E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.06|P-value:8.44E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.56|P-value:1.31E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.71|P-value:4.18E-12 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.30|P-value:4.94E-31 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.14|P-value:8.94E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.76|P-value:5.84E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.72|P-value:7.05E-7 ID:SGTC_2788|Compound:5282734|FD-Score:3.68|P-value:8.25E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-5.24|P-value:7.75E-8 ID:SGTC_2798|Compound:7813637|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.25|P-value:6.07E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.60|P-value:1.11E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-3.13|P-value:9.30E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.38|P-value:1.95E-8 ID:SGTC_3125|Compound:9127534|FD-Score:4.32|P-value:4.96E-6 ID:SGTC_3143|Compound:9086658|FD-Score:3.25|P-value:4.26E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.74|P-value:6.41E-7 ID:SGTC_3153|Compound:9100258|FD-Score:3.39|P-value:2.50E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.84|P-value:6.23E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.98|P-value:2.34E-5 ID:SGTC_3297|Compound:9117502|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_3311|Compound:9131146|FD-Score:9.61|P-value:7.87E-23 ID:SGTC_3312|Compound:9133330|FD-Score:-4.87|P-value:5.53E-7 ID:SGTC_3323|Compound:9138564|FD-Score:3.68|P-value:8.16E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-3.21|P-value:6.94E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.38|P-value:2.57E-4

Top fitness defect scores for YMR102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1568 digitonin 42.30 820.0 nM 0 sphingolipid biosynthesis & PDR1 1 0
2 SGTC_266 formosanin C 37.20 406.0 nM 0 sphingolipid biosynthesis & PDR1 1 5.46E-303
3 SGTC_1941 st076221 15.30 61.8 µM 2.02E-54 sphingolipid biosynthesis & PDR1 2 6.26E-53
4 SGTC_513 4245-1575 12.30 41.7 µM 7.14E-36 unfolded protein response 8 7.43E-35
5 SGTC_955 1216-0110 12.20 33.0 µM 1.00E-35 sphingolipid biosynthesis & PDR1 10 1.04E-34
6 SGTC_2582 agaric acid 11.30 100.0 µM 4.94E-31 redox potentiating 48 3.85E-30
7 SGTC_470 aa-861 10.70 153.0 µM 4.65E-28 sphingolipid biosynthesis & PDR1 7 3.03E-27
8 SGTC_543 3844-1095 10.10 191.0 µM 3.24E-25 ERG2 2 1.77E-24
9 SGTC_3311 9131146 9.61 2.9 µM 7.87E-23 cell wall 17 3.72E-22
10 SGTC_628 1636-0253 8.97 16.0 µM 3.71E-20 sphingolipid biosynthesis & PDR1 4 1.48E-19
11 SGTC_439 amiodarone 8.35 34.4 µM 9.93E-18 NEO1-PIK1 20 3.41E-17
12 SGTC_453 enantio-paf c16 8.14 10.0 µM 6.20E-17 11 2.02E-16
13 SGTC_683 panaxydol 7.35 45.0 µM 3.75E-14 sphingolipid biosynthesis & PDR1 7 1.02E-13
14 SGTC_1872 amphotericin b 7.22 148.0 nM 9.75E-14 RNA pol III & RNase P/MRP 9 2.59E-13
15 SGTC_2482 5981709 7.18 142.7 µM 1.28E-13 PDR1 4 3.38E-13
16 SGTC_794 k038-0031 7.08 316.0 µM 2.76E-13 ubiquinone biosynthesis & proteasome 40 7.13E-13
17 SGTC_2581 avocatin a 6.71 64.0 µM 4.18E-12 sphingolipid biosynthesis & PDR1 13 9.98E-12
18 SGTC_36 0335-0881 6.49 14.2 µM 1.89E-11 ubiquinone biosynthesis & proteasome 54 4.32E-11
19 SGTC_846 0335-0850 6.15 148.0 µM 1.76E-10 ubiquinone biosynthesis & proteasome 14 3.78E-10
20 SGTC_90 0870-0863 5.87 4.6 µM 1.05E-9 16 2.14E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.629 0 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.538 2.03E-251 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.406 1.06E-133 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.391 9.07E-123 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.384 5.18E-118 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.334 1.88E-88 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.296 6.55E-69 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.262 1.22E-53 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.259 1.00E-52 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.257 1.27E-51 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.242 3.98E-46 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.233 1.04E-42 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.226 5.11E-40 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.225 8.33E-40 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.220 6.57E-38 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus