YMR105W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR105W-A / YMR105W-A

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:4.11|P-value:6.94E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:4.44|P-value:1.87E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.62|P-value:8.31E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:3.48|P-value:6.65E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.69|P-value:3.20E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.54|P-value:6.54E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:3.36|P-value:9.74E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.62|P-value:4.17E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.28|P-value:3.59E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.27|P-value:3.77E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.58|P-value:4.66E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.37|P-value:5.63E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.37|P-value:9.29E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.96|P-value:1.22E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.96|P-value:6.84E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.32|P-value:6.58E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.68|P-value:3.38E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.62|P-value:4.09E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.85|P-value:1.02E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.82|P-value:1.84E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.89|P-value:1.60E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.34|P-value:1.67E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.59|P-value:4.52E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.34|P-value:6.19E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.33|P-value:6.46E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.97|P-value:1.18E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.20|P-value:3.68E-9 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.12|P-value:6.86E-5 ID:SGTC_1620|Compound:st003704|FD-Score:4.06|P-value:8.56E-5 ID:SGTC_1668|Compound:st014914|FD-Score:4.78|P-value:4.56E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.21|P-value:6.21E-7 ID:SGTC_1849|Compound:st056239|FD-Score:3.53|P-value:5.58E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.08|P-value:7.86E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.41|P-value:8.40E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.65|P-value:3.77E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.42|P-value:7.92E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.26|P-value:3.98E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.76|P-value:2.57E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.93|P-value:1.67E-8 ID:SGTC_2399|Compound:5884133|FD-Score:-3.92|P-value:7.91E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.12|P-value:6.81E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.03|P-value:1.47E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.44|P-value:4.50E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.61|P-value:9.50E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.99|P-value:1.73E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.70|P-value:3.12E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.69|P-value:3.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.22|P-value:4.66E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.84|P-value:1.90E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.71|P-value:1.74E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-6.29|P-value:9.16E-10 ID:SGTC_2939|Compound:9044578|FD-Score:6.97|P-value:3.87E-11 ID:SGTC_2953|Compound:9074162|FD-Score:3.38|P-value:9.16E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.62|P-value:4.14E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.30|P-value:3.37E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.96|P-value:6.78E-5 ID:SGTC_3208|Compound:9114115|FD-Score:4.69|P-value:6.54E-6 ID:SGTC_3269|Compound:9137823|FD-Score:4.33|P-value:2.98E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:4.11|P-value:6.94E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:4.44|P-value:1.87E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.62|P-value:8.31E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:3.48|P-value:6.65E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.69|P-value:3.20E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.54|P-value:6.54E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:3.36|P-value:9.74E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.62|P-value:4.17E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.28|P-value:3.59E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:4.27|P-value:3.77E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.58|P-value:4.66E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.37|P-value:5.63E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.37|P-value:9.29E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.96|P-value:1.22E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.96|P-value:6.84E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.32|P-value:6.58E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.68|P-value:3.38E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.62|P-value:4.09E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.85|P-value:1.02E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.82|P-value:1.84E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.89|P-value:1.60E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.34|P-value:1.67E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.59|P-value:4.52E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.34|P-value:6.19E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.33|P-value:6.46E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.97|P-value:1.18E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.20|P-value:3.68E-9 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.12|P-value:6.86E-5 ID:SGTC_1620|Compound:st003704|FD-Score:4.06|P-value:8.56E-5 ID:SGTC_1668|Compound:st014914|FD-Score:4.78|P-value:4.56E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.21|P-value:6.21E-7 ID:SGTC_1849|Compound:st056239|FD-Score:3.53|P-value:5.58E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.08|P-value:7.86E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.41|P-value:8.40E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.65|P-value:3.77E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.42|P-value:7.92E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.26|P-value:3.98E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.76|P-value:2.57E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.93|P-value:1.67E-8 ID:SGTC_2399|Compound:5884133|FD-Score:-3.92|P-value:7.91E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.12|P-value:6.81E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.03|P-value:1.47E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.44|P-value:4.50E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.61|P-value:9.50E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.99|P-value:1.73E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.70|P-value:3.12E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.69|P-value:3.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.22|P-value:4.66E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.84|P-value:1.90E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.71|P-value:1.74E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-6.29|P-value:9.16E-10 ID:SGTC_2939|Compound:9044578|FD-Score:6.97|P-value:3.87E-11 ID:SGTC_2953|Compound:9074162|FD-Score:3.38|P-value:9.16E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.62|P-value:4.14E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.30|P-value:3.37E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.96|P-value:6.78E-5 ID:SGTC_3208|Compound:9114115|FD-Score:4.69|P-value:6.54E-6 ID:SGTC_3269|Compound:9137823|FD-Score:4.33|P-value:2.98E-5

Top fitness defect scores for YMR105W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2939 9044578 6.97 71.4 µM 3.87E-11 11 1.62E-12
2 SGTC_1160 4092-0570 6.34 10.5 µM 1.67E-9 plasma membrane duress 13 1.14E-10
3 SGTC_1368 1852-0141 6.20 284.0 µM 3.68E-9 ERG2 7 2.79E-10
4 SGTC_2342 7990637 5.93 118.9 µM 1.67E-8 RNA processing & uracil transport 4 1.54E-9
5 SGTC_58 0957-0393 5.62 9.0 µM 8.31E-8 cell wall 234 9.50E-9
6 SGTC_1732 st034308 5.21 51.8 µM 6.21E-7 10 9.27E-8
7 SGTC_2499 avocadenofuran 5.03 51.5 µM 1.47E-6 16 2.45E-7
8 SGTC_2591 skatole 4.99 100.0 µM 1.73E-6 10 2.96E-7
9 SGTC_1668 st014914 4.78 51.6 µM 4.56E-6 RPP1 & pyrimidine depletion 1 8.88E-7
10 SGTC_3208 9114115 4.69 49.5 µM 6.54E-6 22 1.34E-6
11 SGTC_2580 diallyl disulphide 4.61 81.4 µM 9.50E-6 12 2.04E-6
12 SGTC_42 0133-0086 4.44 60.6 µM 1.87E-5 16 4.41E-6
13 SGTC_3269 9137823 4.33 49.5 µM 2.98E-5 60S ribosome export 12 7.45E-6
14 SGTC_3040 9091894 4.30 49.5 µM 3.37E-5 DNA intercalators 16 8.59E-6
15 SGTC_350 k064-0020 4.28 19.8 µM 3.59E-5 heme requiring 21 9.20E-6
16 SGTC_382 3229-0966 4.27 23.2 µM 3.77E-5 13 9.73E-6
17 SGTC_2308 7584454 4.26 197.6 µM 3.98E-5 16 1.04E-5
18 SGTC_2912 7964298 4.22 10.9 µM 4.66E-5 cell wall 85 1.24E-5
19 SGTC_2402 5553605 4.12 200.0 µM 6.81E-5 19 1.91E-5
20 SGTC_1545 lovastatin 4.12 49.4 µM 6.86E-5 20 1.92E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.57E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.100 6.38E-9 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.097 1.64E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.097 1.69E-8 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.096 2.30E-8 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.095 4.00E-8 YMR223W UBP8 hom Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
0.092 8.07E-8 YGR221C TOS2 hom Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
0.090 1.60E-7 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.090 1.59E-7 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.089 2.54E-7 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.088 3.05E-7 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.086 5.76E-7 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.085 7.87E-7 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.085 8.44E-7 YBR281C DUG2 hom Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
0.082 2.22E-6 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1