YMR112C / MED11

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR112C / MED11

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.29|P-value:2.58E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-2.59|P-value:7.95E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.99|P-value:1.11E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.71|P-value:4.13E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.66|P-value:3.93E-6 ID:SGTC_499|Compound:genistein|FD-Score:-2.61|P-value:7.41E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:2.97|P-value:1.26E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-2.56|P-value:9.16E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:-2.57|P-value:8.90E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.14|P-value:6.32E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-2.88|P-value:2.20E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.56|P-value:9.00E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.69|P-value:5.29E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.59|P-value:5.80E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.90|P-value:9.52E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:2.59|P-value:6.97E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.52|P-value:1.30E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:2.72|P-value:4.04E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:2.90|P-value:1.76E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-2.82|P-value:2.94E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-2.58|P-value:8.30E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:2.51|P-value:9.89E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.24|P-value:3.33E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:2.88|P-value:1.89E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:2.55|P-value:8.15E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-2.76|P-value:3.84E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.02|P-value:4.53E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.50|P-value:9.94E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.95|P-value:1.36E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.64|P-value:5.52E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.21|P-value:3.78E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.90|P-value:7.84E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:2.84|P-value:2.27E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.70|P-value:4.41E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.67|P-value:4.63E-9 ID:SGTC_1697|Compound:st025554|FD-Score:2.65|P-value:5.39E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.65|P-value:6.23E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.93|P-value:1.54E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.55|P-value:8.27E-4 ID:SGTC_2118|Compound:5526350|FD-Score:2.56|P-value:7.90E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.35|P-value:1.83E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-2.69|P-value:5.30E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-7.26|P-value:3.54E-19 ID:SGTC_2415|Compound:st077333|FD-Score:4.66|P-value:4.88E-9 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.30|P-value:2.40E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.17|P-value:1.42E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.12|P-value:1.93E-7 ID:SGTC_2691|Compound:st077356|FD-Score:2.78|P-value:3.06E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.53|P-value:8.83E-4 ID:SGTC_2794|Compound:7785382|FD-Score:2.53|P-value:8.85E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.81|P-value:1.58E-9 ID:SGTC_2855|Compound:9016525|FD-Score:-4.58|P-value:1.10E-8 ID:SGTC_2862|Compound:9027634|FD-Score:-3.02|P-value:1.17E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-2.74|P-value:4.28E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-2.78|P-value:3.49E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.97|P-value:1.45E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.32|P-value:2.59E-5 ID:SGTC_3097|Compound:9117246|FD-Score:-2.76|P-value:3.93E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-2.63|P-value:6.75E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.05|P-value:8.35E-5 ID:SGTC_3313|Compound:9133968|FD-Score:2.63|P-value:5.84E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.29|P-value:2.58E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-2.59|P-value:7.95E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.99|P-value:1.11E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.71|P-value:4.13E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.66|P-value:3.93E-6 ID:SGTC_499|Compound:genistein|FD-Score:-2.61|P-value:7.41E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:2.97|P-value:1.26E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-2.56|P-value:9.16E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:-2.57|P-value:8.90E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.14|P-value:6.32E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-2.88|P-value:2.20E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.56|P-value:9.00E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.69|P-value:5.29E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.59|P-value:5.80E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.90|P-value:9.52E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:2.59|P-value:6.97E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.52|P-value:1.30E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:2.72|P-value:4.04E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:2.90|P-value:1.76E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-2.82|P-value:2.94E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-2.58|P-value:8.30E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:2.51|P-value:9.89E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.24|P-value:3.33E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:2.88|P-value:1.89E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:2.55|P-value:8.15E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-2.76|P-value:3.84E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.02|P-value:4.53E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.50|P-value:9.94E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.95|P-value:1.36E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.64|P-value:5.52E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.21|P-value:3.78E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.90|P-value:7.84E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:2.84|P-value:2.27E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.70|P-value:4.41E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.67|P-value:4.63E-9 ID:SGTC_1697|Compound:st025554|FD-Score:2.65|P-value:5.39E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.65|P-value:6.23E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.93|P-value:1.54E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.55|P-value:8.27E-4 ID:SGTC_2118|Compound:5526350|FD-Score:2.56|P-value:7.90E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.35|P-value:1.83E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-2.69|P-value:5.30E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-7.26|P-value:3.54E-19 ID:SGTC_2415|Compound:st077333|FD-Score:4.66|P-value:4.88E-9 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.30|P-value:2.40E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.17|P-value:1.42E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.12|P-value:1.93E-7 ID:SGTC_2691|Compound:st077356|FD-Score:2.78|P-value:3.06E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.53|P-value:8.83E-4 ID:SGTC_2794|Compound:7785382|FD-Score:2.53|P-value:8.85E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.81|P-value:1.58E-9 ID:SGTC_2855|Compound:9016525|FD-Score:-4.58|P-value:1.10E-8 ID:SGTC_2862|Compound:9027634|FD-Score:-3.02|P-value:1.17E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-2.74|P-value:4.28E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-2.78|P-value:3.49E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.97|P-value:1.45E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.32|P-value:2.59E-5 ID:SGTC_3097|Compound:9117246|FD-Score:-2.76|P-value:3.93E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-2.63|P-value:6.75E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.05|P-value:8.35E-5 ID:SGTC_3313|Compound:9133968|FD-Score:2.63|P-value:5.84E-4

Top fitness defect scores for YMR112C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2852 9023854 4.81 52.0 µM 1.58E-9 3 7.38E-7 0.36
2 SGTC_1634 st006576 4.67 41.0 µM 4.63E-9 TSC3-RPN4 3 1.52E-6 0.18
3 SGTC_2415 st077333 4.66 57.7 µM 4.88E-9 10 1.58E-6 0.29
4 SGTC_996 3970-0799 4.52 1.8 µM 1.30E-8 19 3.04E-6 0.20
5 SGTC_2583 asiatic acid 4.17 100.0 µM 1.42E-7 7 1.52E-5 0.08
6 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 4.12 100.0 µM 1.93E-7 60S ribosome export 9 1.87E-5 0.09
7 SGTC_1520 flindersine 3.90 88.0 µM 7.84E-7 11 4.81E-5 0.12
8 SGTC_2158 5657123 3.35 3.6 µM 1.83E-5 22 4.04E-4 0.21
9 SGTC_2568 diosmetin 3.30 100.0 µM 2.40E-5 19 4.86E-4 0.18
10 SGTC_49 0717-0965 3.29 32.1 µM 2.58E-5 60S ribosome export 16 5.10E-4 3.95E-4
11 SGTC_1174 0739-0097 3.24 51.1 µM 3.33E-5 redox potentiating 8 6.07E-4 0.05
12 SGTC_1517 deoxycholic acid methyl ester 3.21 49.2 µM 3.78E-5 4 6.61E-4 0.11
13 SGTC_3218 9131285 3.05 49.5 µM 8.35E-5 endomembrane recycling 13 0.00113 0.14
14 SGTC_353 1988-1175 2.99 58.3 µM 1.11E-4 unfolded protein response 26 0.00137 0.05
15 SGTC_501 nsc-95397 2.97 161.0 µM 1.26E-4 16 0.00150 0.07
16 SGTC_1472 k841-0093 2.95 193.0 µM 1.36E-4 10 0.00157 0.03
17 SGTC_2002 4023503 2.93 131.0 µM 1.54E-4 mitochondrial processes 26 0.00172 0.04
18 SGTC_1060 3448-7350 2.90 82.0 µM 1.76E-4 Golgi 30 0.00188 0.04
19 SGTC_1259 0671-0132 2.88 43.0 µM 1.89E-4 19 0.00197 0.03
20 SGTC_1583 clindamycin 2.84 39.6 µM 2.27E-4 mitochondrial processes 27 0.00223 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.00E-38 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.217 6.29E-37 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.205 3.79E-33 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.183 1.36E-26 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.173 7.52E-24 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.169 7.16E-23 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.167 2.17E-22 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.160 1.38E-20 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.155 1.92E-19 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.154 3.20E-19 YGR174W-A_p YGR174W-A_p hom Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis
0.154 3.01E-19 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.154 3.64E-19 YHR180W_d YHR180W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.149 3.30E-18 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
0.147 8.94E-18 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.147 1.21E-17 YGR121W-A_p YGR121W-A_p hom Putative protein of unknown function