YMR114C

Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR114C / YMR114C

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:-3.22|P-value:4.28E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.79|P-value:4.24E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.66|P-value:7.02E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.13|P-value:5.87E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.42|P-value:2.31E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.18|P-value:4.95E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.79|P-value:4.25E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.20|P-value:6.74E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.25|P-value:3.83E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.04|P-value:8.26E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.00|P-value:1.72E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.18|P-value:4.87E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.28|P-value:3.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.00|P-value:9.56E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.35|P-value:2.64E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.33|P-value:3.64E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.25|P-value:5.41E-6 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.83|P-value:3.56E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.02|P-value:8.84E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.23|P-value:4.04E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.49|P-value:1.50E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.79|P-value:4.23E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.49|P-value:1.47E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.30|P-value:3.11E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-5.63|P-value:2.78E-9 ID:SGTC_2090|Compound:5301565|FD-Score:-3.13|P-value:5.82E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.27|P-value:3.48E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-6.24|P-value:5.10E-11 ID:SGTC_2397|Compound:5161689|FD-Score:3.32|P-value:2.86E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.49|P-value:1.51E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.04|P-value:8.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.30|P-value:3.18E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.85|P-value:3.28E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:2.99|P-value:9.72E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-6.72|P-value:1.64E-12 ID:SGTC_2851|Compound:9015922|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.76|P-value:4.93E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-6.00|P-value:2.50E-10 ID:SGTC_2878|Compound:9043973|FD-Score:-4.57|P-value:1.10E-6 ID:SGTC_2891|Compound:9063876|FD-Score:-3.15|P-value:5.45E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.06|P-value:7.69E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.79|P-value:4.27E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.01|P-value:9.08E-4 ID:SGTC_3319|Compound:9138450|FD-Score:5.88|P-value:5.61E-10 ID:SGTC_19|Compound:0279-0214|FD-Score:-3.22|P-value:4.28E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.79|P-value:4.24E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.66|P-value:7.02E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.13|P-value:5.87E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.42|P-value:2.31E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.18|P-value:4.95E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.79|P-value:4.25E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.20|P-value:6.74E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.25|P-value:3.83E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.04|P-value:8.26E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.00|P-value:1.72E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.18|P-value:4.87E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.28|P-value:3.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.00|P-value:9.56E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.35|P-value:2.64E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.33|P-value:3.64E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.25|P-value:5.41E-6 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.83|P-value:3.56E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.02|P-value:8.84E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.23|P-value:4.04E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.49|P-value:1.50E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.79|P-value:4.23E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.49|P-value:1.47E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.30|P-value:3.11E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-5.63|P-value:2.78E-9 ID:SGTC_2090|Compound:5301565|FD-Score:-3.13|P-value:5.82E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.27|P-value:3.48E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-6.24|P-value:5.10E-11 ID:SGTC_2397|Compound:5161689|FD-Score:3.32|P-value:2.86E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.49|P-value:1.51E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.04|P-value:8.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.30|P-value:3.18E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.85|P-value:3.28E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:2.99|P-value:9.72E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-6.72|P-value:1.64E-12 ID:SGTC_2851|Compound:9015922|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.76|P-value:4.93E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-6.00|P-value:2.50E-10 ID:SGTC_2878|Compound:9043973|FD-Score:-4.57|P-value:1.10E-6 ID:SGTC_2891|Compound:9063876|FD-Score:-3.15|P-value:5.45E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.06|P-value:7.69E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.79|P-value:4.27E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.01|P-value:9.08E-4 ID:SGTC_3319|Compound:9138450|FD-Score:5.88|P-value:5.61E-10

Top fitness defect scores for YMR114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3319 9138450 5.88 16.8 µM 5.61E-10 3 2.06E-9
2 SGTC_64 000l-0018 4.66 272.1 µM 7.02E-7 ubiquinone biosynthesis & proteasome 120 1.61E-6
3 SGTC_1218 1348-1416 4.33 30.7 µM 3.64E-6 SWF1 & branched chain AA biosynthesis 11 7.48E-6
4 SGTC_1227 3909-8010 4.25 46.6 µM 5.41E-6 11 1.08E-5
5 SGTC_234 nsc-17383 4.20 10.7 µM 6.74E-6 ERG2 19 1.33E-5
6 SGTC_811 0416-0114 4.00 265.0 µM 1.72E-5 18 3.19E-5
7 SGTC_2592 piperlongumine 3.85 83.3 µM 3.28E-5 TSC3-RPN4 43 5.84E-5
8 SGTC_1236 0330-0013 3.83 258.0 µM 3.56E-5 11 6.31E-5
9 SGTC_1370 2001-0092 3.79 44.6 µM 4.23E-5 43 7.41E-5
10 SGTC_217 ketoconazole 3.79 989.0 nM 4.25E-5 ergosterol depletion effects on membrane 27 7.44E-5
11 SGTC_2855 9016525 3.76 58.4 µM 4.93E-5 20 8.54E-5
12 SGTC_1789 tunicamycin 3.49 25.0 nM 1.47E-4 unfolded protein response 66 2.38E-4
13 SGTC_1367 1812-0510 3.49 76.9 µM 1.50E-4 39 2.42E-4
14 SGTC_2400 5203494 3.49 178.7 µM 1.51E-4 RSC complex & mRNA processing 34 2.44E-4
15 SGTC_2851 9015922 3.36 71.4 µM 2.53E-4 68 3.94E-4
16 SGTC_969 1313-0238 3.35 134.0 µM 2.64E-4 mitochondrial processes 43 4.11E-4
17 SGTC_2397 5161689 3.32 200.0 µM 2.86E-4 62 4.42E-4
18 SGTC_2495 cafestol 3.30 54.5 µM 3.18E-4 Golgi 50 4.88E-4
19 SGTC_896 0964-0007 3.28 44.5 µM 3.41E-4 25 5.22E-4
20 SGTC_2118 5526350 3.27 200.0 µM 3.48E-4 36 5.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.218 4.66E-37 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.161 6.99E-21 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.152 1.33E-18 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.147 1.18E-17 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.147 1.29E-17 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.144 6.03E-17 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.133 1.52E-14 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.132 1.97E-14 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.117 1.23E-11 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.111 1.39E-10 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.110 2.03E-10 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.110 2.13E-10 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.110 2.22E-10 YDR403W DIT1 hom Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
0.109 2.89E-10 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.109 3.14E-10 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis