YMR116C / ASC1

G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR116C / ASC1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-3.22|P-value:9.49E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.90|P-value:9.51E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:3.26|P-value:7.49E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.74|P-value:1.38E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.82|P-value:1.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.82|P-value:1.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:10.10|P-value:4.85E-23 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.23|P-value:2.20E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:4.29|P-value:1.53E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.60|P-value:2.58E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.32|P-value:6.76E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.04|P-value:4.25E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.18|P-value:9.99E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.52|P-value:3.12E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:11.80|P-value:9.07E-31 ID:SGTC_584|Compound:0986-0246|FD-Score:3.33|P-value:5.96E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.84|P-value:9.62E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.03|P-value:4.49E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.35|P-value:5.68E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.55|P-value:4.87E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.72|P-value:1.48E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.44|P-value:4.10E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.70|P-value:3.98E-11 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.61|P-value:2.22E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.80|P-value:1.53E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.39|P-value:9.88E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.50|P-value:1.37E-10 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.07|P-value:3.85E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.19|P-value:2.33E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.33|P-value:6.10E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.58|P-value:2.48E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.20|P-value:8.58E-10 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.82|P-value:1.01E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.31|P-value:6.51E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.40|P-value:4.81E-4 ID:SGTC_1658|Compound:st012944|FD-Score:6.59|P-value:8.18E-11 ID:SGTC_1689|Compound:st020265|FD-Score:3.85|P-value:9.04E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.30|P-value:7.28E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.89|P-value:7.77E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.95|P-value:6.15E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:9.05E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.31|P-value:6.97E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.66|P-value:1.88E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.86|P-value:1.18E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.61|P-value:2.21E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-3.90|P-value:8.46E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.26|P-value:7.49E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.28|P-value:7.69E-4 ID:SGTC_2485|Compound:5633444|FD-Score:4.25|P-value:1.82E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-4.46|P-value:8.15E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.58|P-value:2.50E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.13|P-value:2.94E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.78|P-value:1.34E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.46|P-value:4.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.56|P-value:4.76E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:4.63|P-value:3.41E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.51|P-value:3.51E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.18|P-value:9.89E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.38|P-value:5.00E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.48|P-value:3.56E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.99|P-value:5.34E-5 ID:SGTC_2917|Compound:7979103|FD-Score:5.81|P-value:8.45E-9 ID:SGTC_2951|Compound:9072950|FD-Score:3.29|P-value:6.94E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.52|P-value:3.08E-4 ID:SGTC_3080|Compound:9117754|FD-Score:5.84|P-value:7.28E-9 ID:SGTC_3083|Compound:9117465|FD-Score:-3.80|P-value:1.20E-4 ID:SGTC_3142|Compound:9086498|FD-Score:8.43|P-value:1.45E-16 ID:SGTC_3143|Compound:9086658|FD-Score:-3.27|P-value:8.13E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.41|P-value:4.51E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.88|P-value:8.20E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:-3.22|P-value:9.49E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.90|P-value:9.51E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:3.26|P-value:7.49E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.74|P-value:1.38E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.82|P-value:1.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.82|P-value:1.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:10.10|P-value:4.85E-23 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.23|P-value:2.20E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:4.29|P-value:1.53E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.60|P-value:2.58E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.32|P-value:6.76E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.04|P-value:4.25E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.18|P-value:9.99E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.52|P-value:3.12E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:11.80|P-value:9.07E-31 ID:SGTC_584|Compound:0986-0246|FD-Score:3.33|P-value:5.96E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.84|P-value:9.62E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.03|P-value:4.49E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.35|P-value:5.68E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.55|P-value:4.87E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.72|P-value:1.48E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.44|P-value:4.10E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.70|P-value:3.98E-11 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.61|P-value:2.22E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.80|P-value:1.53E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.39|P-value:9.88E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.50|P-value:1.37E-10 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.07|P-value:3.85E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.19|P-value:2.33E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.33|P-value:6.10E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.58|P-value:2.48E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.20|P-value:8.58E-10 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.82|P-value:1.01E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.31|P-value:6.51E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.40|P-value:4.81E-4 ID:SGTC_1658|Compound:st012944|FD-Score:6.59|P-value:8.18E-11 ID:SGTC_1689|Compound:st020265|FD-Score:3.85|P-value:9.04E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.30|P-value:7.28E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.89|P-value:7.77E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.95|P-value:6.15E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:9.05E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.31|P-value:6.97E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.66|P-value:1.88E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.86|P-value:1.18E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.61|P-value:2.21E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-3.90|P-value:8.46E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.26|P-value:7.49E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.28|P-value:7.69E-4 ID:SGTC_2485|Compound:5633444|FD-Score:4.25|P-value:1.82E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-4.46|P-value:8.15E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.58|P-value:2.50E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.13|P-value:2.94E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.78|P-value:1.34E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.46|P-value:4.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.56|P-value:4.76E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:4.63|P-value:3.41E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.51|P-value:3.51E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.18|P-value:9.89E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.38|P-value:5.00E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.48|P-value:3.56E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.99|P-value:5.34E-5 ID:SGTC_2917|Compound:7979103|FD-Score:5.81|P-value:8.45E-9 ID:SGTC_2951|Compound:9072950|FD-Score:3.29|P-value:6.94E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.52|P-value:3.08E-4 ID:SGTC_3080|Compound:9117754|FD-Score:5.84|P-value:7.28E-9 ID:SGTC_3083|Compound:9117465|FD-Score:-3.80|P-value:1.20E-4 ID:SGTC_3142|Compound:9086498|FD-Score:8.43|P-value:1.45E-16 ID:SGTC_3143|Compound:9086658|FD-Score:-3.27|P-value:8.13E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.41|P-value:4.51E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.88|P-value:8.20E-5

Top fitness defect scores for YMR116C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 11.80 7.5 µM 9.07E-31 ERAD & cell cycle 13 1.35E-32
2 SGTC_103 0844-0104 10.10 51.8 µM 4.85E-23 ERAD & cell cycle 29 2.25E-24
3 SGTC_3142 9086498 8.43 49.5 µM 1.45E-16 iron homeostasis 2 1.73E-17
4 SGTC_1026 k007-1105 6.70 30.6 µM 3.98E-11 ERAD & cell cycle 32 1.05E-11
5 SGTC_1658 st012944 6.59 20.0 µM 8.18E-11 iron homeostasis 21 2.26E-11
6 SGTC_1161 k007-0610 6.50 110.0 µM 1.37E-10 ERAD & cell cycle 51 3.91E-11
7 SGTC_1425 4048-4433 6.20 7.3 µM 8.58E-10 copper-dependent oxidative stress 7 2.74E-10
8 SGTC_3080 9117754 5.84 49.5 µM 7.28E-9 2 2.66E-9
9 SGTC_2917 7979103 5.81 53.8 µM 8.45E-9 5 3.11E-9
10 SGTC_58 0957-0393 4.90 9.0 µM 9.51E-7 cell wall 294 4.68E-7
11 SGTC_2291 7917025 4.86 104.3 µM 1.18E-6 iron homeostasis 32 5.90E-7
12 SGTC_1092 toremifene 4.80 6.3 µM 1.53E-6 8 7.75E-7
13 SGTC_2619 obliquin 4.63 87.9 µM 3.41E-6 cell wall 110 1.81E-6
14 SGTC_2582 agaric acid 4.56 100.0 µM 4.76E-6 redox potentiating 250 2.58E-6
15 SGTC_805 3852-0218 4.55 479.0 µM 4.87E-6 ERAD & cell cycle 50 2.64E-6
16 SGTC_1093 fluphenazine 4.39 8.0 µM 9.88E-6 10 5.60E-6
17 SGTC_457 grayanotoxin iii 4.35 135.0 µM 1.19E-5 49 6.84E-6
18 SGTC_140 0062-0056 4.29 502.5 µM 1.53E-5 17 8.89E-6
19 SGTC_2485 5633444 4.25 17.8 µM 1.82E-5 redox potentiating 33 1.07E-5
20 SGTC_1195 1502-0147 4.19 41.1 µM 2.33E-5 20 1.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 1.11E-99 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.348 6.82E-96 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.290 7.57E-66 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.289 1.23E-65 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.276 1.65E-59 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.265 4.35E-55 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.262 1.19E-53 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.242 5.85E-46 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.235 3.23E-43 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.219 9.23E-38 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.217 5.21E-37 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.217 6.38E-37 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.214 5.23E-36 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.203 2.03E-32 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.194 8.92E-30 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus