YMR119W-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR119W-A / YMR119W-A

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:3.18|P-value:7.09E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.33|P-value:6.75E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.84|P-value:5.75E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.84|P-value:5.57E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:5.08|P-value:1.58E-7 ID:SGTC_619|Compound:1652-1634|FD-Score:4.51|P-value:2.86E-6 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.37|P-value:3.40E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.45|P-value:2.62E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.12|P-value:8.61E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.31|P-value:4.47E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.45|P-value:2.51E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.34|P-value:3.85E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.09|P-value:9.36E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-6.33|P-value:8.74E-11 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.37|P-value:5.49E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.71|P-value:9.71E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.83|P-value:5.96E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.22|P-value:6.08E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.37|P-value:3.56E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.84|P-value:5.35E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-10.70|P-value:2.35E-27 ID:SGTC_1743|Compound:st037606|FD-Score:-9.43|P-value:1.09E-21 ID:SGTC_1746|Compound:st038117|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_1747|Compound:st037496|FD-Score:18.60|P-value:9.32E-79 ID:SGTC_1748|Compound:st037455|FD-Score:4.11|P-value:1.82E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.18|P-value:7.02E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.92|P-value:3.85E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.16|P-value:7.24E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.22|P-value:5.87E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.45|P-value:2.47E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-4.08|P-value:1.93E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.36|P-value:3.56E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.41|P-value:2.91E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.84|P-value:5.59E-7 ID:SGTC_2377|Compound:9073351|FD-Score:3.24|P-value:5.67E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.44|P-value:2.78E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.39|P-value:3.19E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.21|P-value:5.95E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.84|P-value:5.64E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.21|P-value:6.20E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.48|P-value:3.10E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-3.08|P-value:9.63E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-6.45|P-value:4.10E-11 ID:SGTC_2878|Compound:9043973|FD-Score:-5.67|P-value:5.48E-9 ID:SGTC_2919|Compound:7978188|FD-Score:-3.18|P-value:6.74E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.20|P-value:6.19E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.22|P-value:1.05E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.18|P-value:7.04E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.12|P-value:8.20E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.83|P-value:5.87E-7 ID:SGTC_105|Compound:0111-0055|FD-Score:3.18|P-value:7.09E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.33|P-value:6.75E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.84|P-value:5.75E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.84|P-value:5.57E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:5.08|P-value:1.58E-7 ID:SGTC_619|Compound:1652-1634|FD-Score:4.51|P-value:2.86E-6 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.37|P-value:3.40E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.45|P-value:2.62E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.12|P-value:8.61E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.31|P-value:4.47E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.45|P-value:2.51E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.34|P-value:3.85E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.09|P-value:9.36E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-6.33|P-value:8.74E-11 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.37|P-value:5.49E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.71|P-value:9.71E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.83|P-value:5.96E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.22|P-value:6.08E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.37|P-value:3.56E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.84|P-value:5.35E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-10.70|P-value:2.35E-27 ID:SGTC_1743|Compound:st037606|FD-Score:-9.43|P-value:1.09E-21 ID:SGTC_1746|Compound:st038117|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_1747|Compound:st037496|FD-Score:18.60|P-value:9.32E-79 ID:SGTC_1748|Compound:st037455|FD-Score:4.11|P-value:1.82E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.18|P-value:7.02E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.92|P-value:3.85E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.16|P-value:7.24E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.22|P-value:5.87E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.45|P-value:2.47E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-4.08|P-value:1.93E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.36|P-value:3.56E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.41|P-value:2.91E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.84|P-value:5.59E-7 ID:SGTC_2377|Compound:9073351|FD-Score:3.24|P-value:5.67E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.44|P-value:2.78E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.39|P-value:3.19E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.21|P-value:5.95E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.84|P-value:5.64E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.21|P-value:6.20E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.48|P-value:3.10E-6 ID:SGTC_2790|Compound:5423970|FD-Score:-3.08|P-value:9.63E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-6.45|P-value:4.10E-11 ID:SGTC_2878|Compound:9043973|FD-Score:-5.67|P-value:5.48E-9 ID:SGTC_2919|Compound:7978188|FD-Score:-3.18|P-value:6.74E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.20|P-value:6.19E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.22|P-value:1.05E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.18|P-value:7.04E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.12|P-value:8.20E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.83|P-value:5.87E-7

Top fitness defect scores for YMR119W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1747 st037496 18.60 66.6 µM 9.32E-79 1 8.90E-78
2 SGTC_548 1436-0017 5.08 110.0 µM 1.58E-7 TSC3-RPN4 21 1.84E-7
3 SGTC_2336 9001819 4.84 198.7 µM 5.59E-7 heme biosynthesis & mitochondrial translocase 24 6.41E-7
4 SGTC_3201 9113999 4.83 49.5 µM 5.87E-7 14 6.73E-7
5 SGTC_619 1652-1634 4.51 108.0 µM 2.86E-6 PDR1 13 3.22E-6
6 SGTC_1133 3473-0247 4.37 50.0 µM 5.49E-6 RSC complex & mRNA processing 34 6.12E-6
7 SGTC_158 k038-0087 4.33 26.4 µM 6.75E-6 ubiquinone biosynthesis & proteasome 118 7.51E-6
8 SGTC_1748 st037455 4.11 53.6 µM 1.82E-5 27 2.00E-5
9 SGTC_471 1-acyl-paf 3.84 4.0 µM 5.57E-5 DNA intercalators 34 6.06E-5
10 SGTC_2710 st078562 3.84 53.7 µM 5.64E-5 18 6.12E-5
11 SGTC_407 eburnamonine 3.84 100.0 µM 5.75E-5 15 6.24E-5
12 SGTC_1220 1838-0075 3.83 193.0 µM 5.96E-5 14 6.47E-5
13 SGTC_1134 3477-0009 3.71 42.5 µM 9.71E-5 51 1.05E-4
14 SGTC_1746 st038117 3.67 42.0 µM 1.14E-4 40 1.23E-4
15 SGTC_151 3013-0144 3.59 2.3 µM 1.56E-4 iron homeostasis 43 1.67E-4
16 SGTC_744 1594-0068 3.45 283.0 µM 2.62E-4 amide catabolism 48 2.80E-4
17 SGTC_2485 5633444 3.44 17.8 µM 2.78E-4 redox potentiating 68 2.96E-4
18 SGTC_365 0121-0052 3.42 13.6 µM 2.95E-4 mitochondrial response to ROS 88 3.14E-4
19 SGTC_1278 0874-0585 3.37 172.0 µM 3.56E-4 31 3.79E-4
20 SGTC_3049 9092223 3.34 49.5 µM 3.89E-4 44 4.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 2.37E-38 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.208 9.47E-34 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.174 5.62E-24 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.154 3.58E-19 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.141 2.59E-16 YKL085W MDH1 hom Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
0.138 1.37E-15 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.132 2.21E-14 YGR002C SWC4 het Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
0.128 1.11E-13 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.124 6.41E-13 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.121 2.11E-12 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.118 8.28E-12 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.117 1.15E-11 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.116 2.18E-11 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.115 2.32E-11 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.113 7.40E-11 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1