YMR120C / ADE17

Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR120C / ADE17

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.09|P-value:8.60E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:8.80|P-value:2.64E-20 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.95|P-value:2.94E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.44|P-value:2.40E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.04|P-value:6.76E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.26|P-value:4.68E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.58|P-value:1.41E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.98|P-value:2.53E-5 ID:SGTC_447|Compound:ml7|FD-Score:-5.54|P-value:7.54E-9 ID:SGTC_460|Compound:trequinsin|FD-Score:-5.20|P-value:5.37E-8 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-4.26|P-value:7.22E-6 ID:SGTC_549|Compound:1661-1316|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.08|P-value:9.05E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.37|P-value:3.14E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.55|P-value:9.33E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.57|P-value:8.77E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.09|P-value:5.72E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.54|P-value:9.94E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:4.02|P-value:1.25E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.21|P-value:3.56E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-4.17|P-value:1.10E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.26|P-value:3.01E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:5.39|P-value:8.58E-9 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.76|P-value:3.87E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.28|P-value:4.45E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.44|P-value:1.45E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.08|P-value:9.07E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.07|P-value:9.29E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.24|P-value:5.19E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.13|P-value:4.89E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.50|P-value:1.18E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.04|P-value:6.65E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.00|P-value:7.78E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.33|P-value:3.66E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.51|P-value:1.13E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.14|P-value:4.63E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.37|P-value:3.12E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.94|P-value:1.80E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.92|P-value:1.92E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.75|P-value:4.08E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.78|P-value:3.51E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.15|P-value:7.08E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.72|P-value:7.81E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.24|P-value:3.26E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.64|P-value:6.42E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.19|P-value:3.89E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.48|P-value:1.27E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.63|P-value:6.70E-5 ID:SGTC_3099|Compound:9120367|FD-Score:-3.13|P-value:7.50E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.25|P-value:4.90E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.26|P-value:4.82E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-3.07|P-value:9.29E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.29|P-value:2.61E-4 ID:SGTC_3302|Compound:9125395|FD-Score:4.18|P-value:5.96E-6 ID:SGTC_3310|Compound:9130229|FD-Score:6.84|P-value:4.98E-13 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.09|P-value:8.60E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:8.80|P-value:2.64E-20 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.95|P-value:2.94E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.44|P-value:2.40E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.04|P-value:6.76E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.26|P-value:4.68E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.58|P-value:1.41E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.98|P-value:2.53E-5 ID:SGTC_447|Compound:ml7|FD-Score:-5.54|P-value:7.54E-9 ID:SGTC_460|Compound:trequinsin|FD-Score:-5.20|P-value:5.37E-8 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-4.26|P-value:7.22E-6 ID:SGTC_549|Compound:1661-1316|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.08|P-value:9.05E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.37|P-value:3.14E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.55|P-value:9.33E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.57|P-value:8.77E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.09|P-value:5.72E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.54|P-value:9.94E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:4.02|P-value:1.25E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.21|P-value:3.56E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-4.17|P-value:1.10E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.26|P-value:3.01E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:5.39|P-value:8.58E-9 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.76|P-value:3.87E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.28|P-value:4.45E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.44|P-value:1.45E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.08|P-value:9.07E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.07|P-value:9.29E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.24|P-value:5.19E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.13|P-value:4.89E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.50|P-value:1.18E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.04|P-value:6.65E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.00|P-value:7.78E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.33|P-value:3.66E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.51|P-value:1.13E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.14|P-value:4.63E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.37|P-value:3.12E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.94|P-value:1.80E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.92|P-value:1.92E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.75|P-value:4.08E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.78|P-value:3.51E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.15|P-value:7.08E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.72|P-value:7.81E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.24|P-value:3.26E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.64|P-value:6.42E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.19|P-value:3.89E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.48|P-value:1.27E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.63|P-value:6.70E-5 ID:SGTC_3099|Compound:9120367|FD-Score:-3.13|P-value:7.50E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.25|P-value:4.90E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.26|P-value:4.82E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-3.07|P-value:9.29E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.29|P-value:2.61E-4 ID:SGTC_3302|Compound:9125395|FD-Score:4.18|P-value:5.96E-6 ID:SGTC_3310|Compound:9130229|FD-Score:6.84|P-value:4.98E-13

Top fitness defect scores for YMR120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_123 0083-0120 8.80 66.7 µM 2.64E-20 8 6.89E-19
2 SGTC_3310 9130229 6.84 44.1 µM 4.98E-13 Golgi 3 4.02E-12
3 SGTC_991 3996-0057 5.39 64.7 µM 8.58E-9 4 3.45E-8
4 SGTC_3302 9125395 4.18 16.4 µM 5.96E-6 5 1.49E-5
5 SGTC_798 1287-0182 4.02 476.0 µM 1.25E-5 20 2.96E-5
6 SGTC_2587 piperic acid 3.94 92.2 µM 1.80E-5 25 4.13E-5
7 SGTC_2620 irigenin 3.92 100.0 µM 1.92E-5 42 4.40E-5
8 SGTC_2754 granisetron 3.78 64.0 µM 3.51E-5 38 7.69E-5
9 SGTC_1106 tegaserod maleate 3.76 11.7 µM 3.87E-5 27 8.41E-5
10 SGTC_2687 chenodiol 3.75 100.0 µM 4.08E-5 28 8.84E-5
11 SGTC_2808 7946468 3.64 45.5 µM 6.42E-5 34 1.34E-4
12 SGTC_3030 9087619 3.63 49.5 µM 6.70E-5 18 1.40E-4
13 SGTC_618 k072-0232 3.57 33.2 µM 8.77E-5 60S ribosome export 14 1.79E-4
14 SGTC_592 k241-0073 3.55 46.5 µM 9.33E-5 28 1.90E-4
15 SGTC_696 1560-0013 3.54 611.0 µM 9.94E-5 35 2.01E-4
16 SGTC_2434 5670830 3.51 169.9 µM 1.13E-4 41 2.28E-4
17 SGTC_1654 st012436 3.50 41.8 µM 1.18E-4 26 2.37E-4
18 SGTC_3029 9088683 3.48 49.5 µM 1.27E-4 32 2.53E-4
19 SGTC_1196 1588-0294 3.44 184.0 µM 1.45E-4 25 2.86E-4
20 SGTC_3299 9121982 3.29 43.1 µM 2.61E-4 56 4.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 4.20E-45 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.182 1.74E-26 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.148 6.03E-18 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.140 4.82E-16 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.129 7.63E-14 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
0.100 7.08E-9 YLL015W BPT1 hom ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.094 4.99E-8 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.084 1.15E-6 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.083 1.30E-6 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.082 1.90E-6 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.079 4.93E-6 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.078 5.77E-6 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.078 5.92E-6 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.075 1.30E-5 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.075 1.44E-5 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies