YMR121C / RPL15B

Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR121C / RPL15B

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.60|P-value:3.91E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:3.06|P-value:7.05E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.36|P-value:1.56E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.92|P-value:2.38E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-3.40|P-value:3.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.36|P-value:2.94E-11 ID:SGTC_496|Compound:calpeptin|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:17.00|P-value:4.67E-68 ID:SGTC_549|Compound:1661-1316|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.63|P-value:1.58E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.77|P-value:4.20E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:3.04|P-value:7.44E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.03|P-value:7.72E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.23|P-value:6.77E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:5.40|P-value:1.24E-8 ID:SGTC_781|Compound:4335-2806|FD-Score:3.10|P-value:6.03E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.31|P-value:3.99E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:3.96|P-value:1.96E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.06|P-value:6.96E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.67|P-value:6.80E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.33|P-value:3.69E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.77|P-value:4.63E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.47|P-value:2.83E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-3.27|P-value:6.03E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.99|P-value:8.86E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.11|P-value:5.81E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.99|P-value:1.74E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.61|P-value:2.11E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.11|P-value:5.85E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.77|P-value:4.47E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.58|P-value:9.88E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.44|P-value:2.19E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.50|P-value:2.58E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.26|P-value:3.48E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.52|P-value:1.47E-6 ID:SGTC_2144|Compound:5628481|FD-Score:-3.32|P-value:5.06E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.29|P-value:3.04E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.40|P-value:2.00E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.70|P-value:5.96E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.22|P-value:3.97E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.80|P-value:4.03E-5 ID:SGTC_2462|Compound:5162487|FD-Score:2.97|P-value:9.70E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.84|P-value:6.74E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.26|P-value:5.08E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:8.48|P-value:1.66E-18 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.49|P-value:2.67E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.59|P-value:9.38E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.51|P-value:2.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.05|P-value:2.18E-7 ID:SGTC_2912|Compound:7964298|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.16|P-value:4.90E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.20|P-value:7.72E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-3.16|P-value:8.91E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.00|P-value:8.72E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.04|P-value:1.39E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.60|P-value:3.91E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:3.06|P-value:7.05E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.36|P-value:1.56E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.92|P-value:2.38E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-3.40|P-value:3.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.36|P-value:2.94E-11 ID:SGTC_496|Compound:calpeptin|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:17.00|P-value:4.67E-68 ID:SGTC_549|Compound:1661-1316|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.63|P-value:1.58E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.77|P-value:4.20E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:3.04|P-value:7.44E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.03|P-value:7.72E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.23|P-value:6.77E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:5.40|P-value:1.24E-8 ID:SGTC_781|Compound:4335-2806|FD-Score:3.10|P-value:6.03E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.31|P-value:3.99E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:3.96|P-value:1.96E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.06|P-value:6.96E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.67|P-value:6.80E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.33|P-value:3.69E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.77|P-value:4.63E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.47|P-value:2.83E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-3.27|P-value:6.03E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.99|P-value:8.86E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.11|P-value:5.81E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.99|P-value:1.74E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.61|P-value:2.11E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.11|P-value:5.85E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.77|P-value:4.47E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.58|P-value:9.88E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.44|P-value:2.19E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.50|P-value:2.58E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.26|P-value:3.48E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.52|P-value:1.47E-6 ID:SGTC_2144|Compound:5628481|FD-Score:-3.32|P-value:5.06E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.29|P-value:3.04E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.40|P-value:2.00E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.70|P-value:5.96E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.22|P-value:3.97E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.80|P-value:4.03E-5 ID:SGTC_2462|Compound:5162487|FD-Score:2.97|P-value:9.70E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.84|P-value:6.74E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.26|P-value:5.08E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:8.48|P-value:1.66E-18 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.49|P-value:2.67E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.59|P-value:9.38E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.51|P-value:2.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.05|P-value:2.18E-7 ID:SGTC_2912|Compound:7964298|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.16|P-value:4.90E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.20|P-value:7.72E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-3.16|P-value:8.91E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.00|P-value:8.72E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.04|P-value:1.39E-5

Top fitness defect scores for YMR121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 17.00 2.6 nM 4.67E-68 cell wall 4 2.35E-65
2 SGTC_2619 obliquin 8.48 87.9 µM 1.66E-18 cell wall 39 1.13E-17
3 SGTC_453 enantio-paf c16 6.36 10.0 µM 2.94E-11 35 1.01E-10
4 SGTC_58 0957-0393 5.60 9.0 µM 3.91E-9 cell wall 236 1.08E-8
5 SGTC_777 1315-0167 5.40 517.0 µM 1.24E-8 Golgi 12 3.26E-8
6 SGTC_138 0850-0259 5.36 40.9 µM 1.56E-8 cell wall 130 4.07E-8
7 SGTC_637 1181-0519 4.77 7.3 µM 4.20E-7 fatty acid desaturase (OLE1) 72 9.44E-7
8 SGTC_2111 5486399 4.52 200.0 µM 1.47E-6 31 3.11E-6
9 SGTC_2054 5233173 4.44 129.0 µM 2.19E-6 mitochondrial response to ROS 41 4.56E-6
10 SGTC_1083 didemethylchlorpromazine sulfoxide 4.33 707.4 nM 3.69E-6 redox potentiating 58 7.50E-6
11 SGTC_792 4534-1957 4.31 155.0 µM 3.99E-6 23 8.07E-6
12 SGTC_2582 agaric acid 4.26 100.0 µM 5.08E-6 redox potentiating 285 1.02E-5
13 SGTC_3311 9131146 4.04 2.9 µM 1.39E-5 cell wall 117 2.66E-5
14 SGTC_1921 5740136 3.99 50.0 µM 1.74E-5 TRP & mitochondrial translation 56 3.28E-5
15 SGTC_839 0122-0028 3.96 230.0 µM 1.96E-5 RSC complex & mRNA processing 38 3.68E-5
16 SGTC_435 c-PAF 3.92 6.7 µM 2.38E-5 44 4.42E-5
17 SGTC_2411 st077133 3.80 39.9 µM 4.03E-5 RNA pol III & RNase P/MRP 36 7.31E-5
18 SGTC_1993 st073995 3.77 70.8 µM 4.47E-5 26 8.06E-5
19 SGTC_1323 1348-1351 3.77 11.2 µM 4.63E-5 12 8.33E-5
20 SGTC_2313 7726885 3.70 200.0 µM 5.96E-5 RPP1 & pyrimidine depletion 42 1.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.460 1.10E-175 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.433 2.56E-153 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.415 3.09E-140 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.405 2.73E-132 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.394 1.00E-124 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.391 1.06E-122 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.371 3.02E-110 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.369 5.15E-109 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.357 4.13E-101 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.353 1.32E-98 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.338 1.02E-90 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.335 1.28E-88 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.309 2.70E-75 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.300 6.86E-71 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.296 6.05E-69 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication