YMR122C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR122C / YMR122C

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:5.64|P-value:2.28E-7 ID:SGTC_48|Compound:0382-0018|FD-Score:3.93|P-value:2.20E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.43|P-value:3.74E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.74|P-value:4.20E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.26|P-value:7.16E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:5.38|P-value:7.45E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:-4.74|P-value:9.28E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.18|P-value:7.79E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.41|P-value:4.09E-5 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.84|P-value:3.04E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.52|P-value:2.63E-5 ID:SGTC_1805|Compound:st050013|FD-Score:-5.58|P-value:2.35E-7 ID:SGTC_1820|Compound:st053765|FD-Score:3.47|P-value:9.68E-4 ID:SGTC_1940|Compound:st075990|FD-Score:5.51|P-value:4.15E-7 ID:SGTC_1945|Compound:st075991|FD-Score:-4.74|P-value:9.28E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.70|P-value:4.13E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.65|P-value:4.74E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.49|P-value:9.15E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.56|P-value:7.47E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.69|P-value:4.96E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.79|P-value:3.58E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.73|P-value:3.70E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.53|P-value:7.07E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.86|P-value:7.85E-8 ID:SGTC_2847|Compound:9005661|FD-Score:-4.43|P-value:3.11E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.76|P-value:3.94E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.79|P-value:3.57E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.73|P-value:4.28E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:5.64|P-value:2.28E-7 ID:SGTC_48|Compound:0382-0018|FD-Score:3.93|P-value:2.20E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.43|P-value:3.74E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.74|P-value:4.20E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.26|P-value:7.16E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:5.38|P-value:7.45E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:-4.74|P-value:9.28E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.18|P-value:7.79E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.41|P-value:4.09E-5 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.84|P-value:3.04E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.52|P-value:2.63E-5 ID:SGTC_1805|Compound:st050013|FD-Score:-5.58|P-value:2.35E-7 ID:SGTC_1820|Compound:st053765|FD-Score:3.47|P-value:9.68E-4 ID:SGTC_1940|Compound:st075990|FD-Score:5.51|P-value:4.15E-7 ID:SGTC_1945|Compound:st075991|FD-Score:-4.74|P-value:9.28E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.70|P-value:4.13E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.65|P-value:4.74E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.49|P-value:9.15E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.56|P-value:7.47E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.69|P-value:4.96E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.79|P-value:3.58E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.73|P-value:3.70E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.53|P-value:7.07E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.86|P-value:7.85E-8 ID:SGTC_2847|Compound:9005661|FD-Score:-4.43|P-value:3.11E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.76|P-value:3.94E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.79|P-value:3.57E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.73|P-value:4.28E-4

Top fitness defect scores for YMR122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2833 9001315 5.86 45.5 µM 7.85E-8 amide catabolism 20 2.33E-9
2 SGTC_47 0149-0135 5.64 24.2 µM 2.28E-7 TSC3-RPN4 4 8.70E-9
3 SGTC_1940 st075990 5.51 51.1 µM 4.15E-7 60S ribosome export 4 1.82E-8
4 SGTC_859 0439-0102 5.38 54.6 µM 7.45E-7 redox potentiating 7 3.75E-8
5 SGTC_1763 st044482 4.52 94.5 µM 2.63E-5 copper-dependent oxidative stress 16 3.04E-6
6 SGTC_287 k060-0039 4.43 29.6 µM 3.74E-5 5 4.70E-6
7 SGTC_1439 4092-1168 4.41 46.0 µM 4.09E-5 6 5.25E-6
8 SGTC_847 0342-0274 4.26 5.5 µM 7.16E-5 15 1.04E-5
9 SGTC_48 0382-0018 3.93 55.0 µM 2.20E-4 9 4.17E-5
10 SGTC_1549 4'-methoxyflavonol 3.84 74.6 µM 3.04E-4 8 6.19E-5
11 SGTC_3005 9076496 3.79 71.4 µM 3.57E-4 8 7.56E-5
12 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.79 100.0 µM 3.58E-4 26 7.57E-5
13 SGTC_2850 9015429 3.76 58.4 µM 3.94E-4 15 8.51E-5
14 SGTC_479 n-linoleoylglycine 3.74 10.0 µM 4.20E-4 12 9.21E-5
15 SGTC_3212 9128307 3.73 49.5 µM 4.28E-4 52 9.42E-5
16 SGTC_2498 4'-Methoxychalcone 3.69 54.6 µM 4.96E-4 RPP1 & pyrimidine depletion 42 1.13E-4
17 SGTC_2344 7990960 3.56 77.0 µM 7.47E-4 36 1.87E-4
18 SGTC_2076 5212012 3.49 200.0 µM 9.15E-4 12 2.40E-4
19 SGTC_1820 st053765 3.47 18.6 µM 9.68E-4 RPP1 & pyrimidine depletion 32 2.57E-4
20 SGTC_1640 st009078 3.45 66.4 µM 0.00103 21 2.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.93E-20 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.121 1.70E-12 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.114 3.04E-11 YCR010C ADY2 hom Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication
0.109 2.77E-10 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.44E-9 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.098 1.11E-8 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.096 2.69E-8 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.095 3.12E-8 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.091 1.23E-7 YDR130C FIN1 hom Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress
0.090 1.63E-7 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.090 1.77E-7 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.086 6.84E-7 YDR532C KRE28 hom Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.084 1.14E-6 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.083 1.49E-6 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.081 2.34E-6 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance