YMR125W / STO1

Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR125W / STO1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.09|P-value:2.81E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:3.58|P-value:6.65E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.75|P-value:3.83E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.86|P-value:3.68E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.56|P-value:7.13E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.47|P-value:3.13E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.66|P-value:5.18E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.01|P-value:1.65E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.27|P-value:9.18E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.75|P-value:3.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.31|P-value:6.51E-11 ID:SGTC_328|Compound:k915-0120|FD-Score:-4.90|P-value:8.55E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:5.11|P-value:2.53E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.62|P-value:7.89E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.78|P-value:3.54E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.71|P-value:5.98E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-4.06|P-value:1.93E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.88|P-value:6.58E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.01|P-value:1.63E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.63|P-value:5.68E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-4.51|P-value:3.97E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:4.61|P-value:1.89E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:5.47|P-value:5.29E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.28|P-value:8.90E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.98|P-value:1.84E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.15|P-value:1.02E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.60|P-value:1.93E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.61|P-value:5.96E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-4.04|P-value:2.02E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.85|P-value:3.83E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.14|P-value:1.44E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.45|P-value:3.40E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.47|P-value:9.23E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-4.85|P-value:1.07E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.10|P-value:1.20E-4 ID:SGTC_2084|Compound:5306078|FD-Score:5.31|P-value:1.06E-6 ID:SGTC_2089|Compound:5281248|FD-Score:-4.49|P-value:4.26E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.64|P-value:1.67E-5 ID:SGTC_2096|Compound:5468907|FD-Score:-4.24|P-value:1.03E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.72|P-value:1.22E-5 ID:SGTC_2340|Compound:7987427|FD-Score:7.43|P-value:1.78E-11 ID:SGTC_2347|Compound:9049783|FD-Score:13.50|P-value:2.39E-33 ID:SGTC_2348|Compound:9022543|FD-Score:-4.82|P-value:1.18E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.26|P-value:6.97E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.96|P-value:4.61E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.88|P-value:9.62E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.28|P-value:1.20E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.21|P-value:8.07E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.89|P-value:2.47E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.09|P-value:2.67E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.39|P-value:7.37E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.54|P-value:7.53E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.89|P-value:6.20E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-5.23|P-value:2.25E-6 ID:SGTC_3043|Compound:9092303|FD-Score:3.71|P-value:4.42E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.77|P-value:1.45E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-5.94|P-value:8.99E-8 ID:SGTC_3149|Compound:9097855|FD-Score:4.33|P-value:5.43E-5 ID:SGTC_3282|Compound:9108498|FD-Score:4.85|P-value:7.40E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-4.50|P-value:3.99E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.61|P-value:5.99E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.65|P-value:5.40E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.63|P-value:5.64E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-5.07|P-value:4.37E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.09|P-value:2.81E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:3.58|P-value:6.65E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.75|P-value:3.83E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.86|P-value:3.68E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.56|P-value:7.13E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.47|P-value:3.13E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.66|P-value:5.18E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.01|P-value:1.65E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.27|P-value:9.18E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.75|P-value:3.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.31|P-value:6.51E-11 ID:SGTC_328|Compound:k915-0120|FD-Score:-4.90|P-value:8.55E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:5.11|P-value:2.53E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.62|P-value:7.89E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.78|P-value:3.54E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.71|P-value:5.98E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-4.06|P-value:1.93E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.88|P-value:6.58E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.01|P-value:1.63E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.63|P-value:5.68E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-4.51|P-value:3.97E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:4.61|P-value:1.89E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:5.47|P-value:5.29E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.28|P-value:8.90E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.98|P-value:1.84E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.15|P-value:1.02E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.60|P-value:1.93E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.61|P-value:5.96E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-4.04|P-value:2.02E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.85|P-value:3.83E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.14|P-value:1.44E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.45|P-value:3.40E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.47|P-value:9.23E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-4.85|P-value:1.07E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.10|P-value:1.20E-4 ID:SGTC_2084|Compound:5306078|FD-Score:5.31|P-value:1.06E-6 ID:SGTC_2089|Compound:5281248|FD-Score:-4.49|P-value:4.26E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.64|P-value:1.67E-5 ID:SGTC_2096|Compound:5468907|FD-Score:-4.24|P-value:1.03E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.72|P-value:1.22E-5 ID:SGTC_2340|Compound:7987427|FD-Score:7.43|P-value:1.78E-11 ID:SGTC_2347|Compound:9049783|FD-Score:13.50|P-value:2.39E-33 ID:SGTC_2348|Compound:9022543|FD-Score:-4.82|P-value:1.18E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.26|P-value:6.97E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.96|P-value:4.61E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.88|P-value:9.62E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.28|P-value:1.20E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.21|P-value:8.07E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.89|P-value:2.47E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.09|P-value:2.67E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.39|P-value:7.37E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.54|P-value:7.53E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.89|P-value:6.20E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-5.23|P-value:2.25E-6 ID:SGTC_3043|Compound:9092303|FD-Score:3.71|P-value:4.42E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.77|P-value:1.45E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-5.94|P-value:8.99E-8 ID:SGTC_3149|Compound:9097855|FD-Score:4.33|P-value:5.43E-5 ID:SGTC_3282|Compound:9108498|FD-Score:4.85|P-value:7.40E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-4.50|P-value:3.99E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.61|P-value:5.99E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.65|P-value:5.40E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.63|P-value:5.64E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-5.07|P-value:4.37E-6

Top fitness defect scores for YMR125W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2347 9049783 13.50 174.8 µM 2.39E-33 2 1.00E-41
2 SGTC_2340 7987427 7.43 183.4 µM 1.78E-11 2 5.30E-14
3 SGTC_58 0957-0393 6.09 9.0 µM 2.81E-8 cell wall 210 5.73E-10
4 SGTC_735 3076-0345 5.47 636.0 µM 5.29E-7 7 2.30E-8
5 SGTC_2598 perillyl alcohol 5.39 100.0 µM 7.37E-7 8 3.48E-8
6 SGTC_2084 5306078 5.31 60.6 µM 1.06E-6 5 5.47E-8
7 SGTC_2536 dehydroabietamide 5.28 32.0 µM 1.20E-6 6 6.45E-8
8 SGTC_422 cantharidin 5.11 155.0 µM 2.53E-6 cell wall signaling 32 1.64E-7
9 SGTC_2593 nobiletin 5.09 86.2 µM 2.67E-6 11 1.75E-7
10 SGTC_2489 cantharidin 4.96 73.4 µM 4.61E-6 cell wall signaling 20 3.47E-7
11 SGTC_3020 9089140 4.89 49.5 µM 6.20E-6 10 5.04E-7
12 SGTC_576 1073-0113 4.88 22.7 µM 6.58E-6 redox potentiating 40 5.43E-7
13 SGTC_3282 9108498 4.85 15.5 µM 7.40E-6 17 6.29E-7
14 SGTC_2322 7413319 4.72 38.2 µM 1.22E-5 ERAD & cell cycle 112 1.18E-6
15 SGTC_2091 4-phenylthiadiazole 4.64 200.0 µM 1.67E-5 7 1.75E-6
16 SGTC_729 4092-0585 4.61 94.1 µM 1.89E-5 13 2.03E-6
17 SGTC_1425 4048-4433 4.60 7.3 µM 1.93E-5 copper-dependent oxidative stress 24 2.09E-6
18 SGTC_226 1,3-diallylurea 4.47 8.3 mM 3.13E-5 7 3.82E-6
19 SGTC_1743 st037606 4.45 46.4 µM 3.40E-5 12 4.24E-6
20 SGTC_3149 9097855 4.33 49.5 µM 5.43E-5 Golgi 19 7.61E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 3.05E-40 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.122 1.42E-12 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.115 2.24E-11 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.112 8.40E-11 YML012C-A_d YML012C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
0.111 1.28E-10 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.106 6.90E-10 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
0.105 1.24E-9 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.104 1.37E-9 YOR198C BFR1 hom Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
0.102 3.03E-9 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.102 3.65E-9 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.102 3.84E-9 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.101 4.69E-9 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.100 7.22E-9 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.098 1.21E-8 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.095 3.42E-8 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin