YMR127C / SAS2

Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR127C / SAS2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.30|P-value:9.44E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:6.07|P-value:4.81E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:6.05|P-value:5.50E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:5.89|P-value:1.67E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:3.61|P-value:5.98E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:5.02|P-value:4.20E-8 ID:SGTC_154|Compound:3389-1638|FD-Score:3.79|P-value:2.67E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:9.67|P-value:3.25E-25 ID:SGTC_165|Compound:k038-0023|FD-Score:3.57|P-value:6.97E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.86|P-value:1.95E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.97|P-value:1.14E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.73|P-value:3.53E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:2.93|P-value:8.99E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.11|P-value:5.80E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.50|P-value:9.46E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.34|P-value:1.88E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.47|P-value:9.49E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:5.03|P-value:4.18E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:4.27|P-value:2.68E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.18|P-value:4.12E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.08|P-value:5.33E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:2.92|P-value:9.23E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.29|P-value:1.01E-11 ID:SGTC_846|Compound:0335-0850|FD-Score:3.78|P-value:2.81E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:11.40|P-value:4.37E-34 ID:SGTC_996|Compound:3970-0799|FD-Score:7.57|P-value:3.53E-16 ID:SGTC_1120|Compound:ficusin|FD-Score:2.96|P-value:8.03E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:17.80|P-value:1.01E-80 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.29|P-value:2.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:9.09|P-value:1.69E-22 ID:SGTC_1317|Compound:1273-0028|FD-Score:8.84|P-value:2.13E-21 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.19|P-value:3.98E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.40|P-value:1.42E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.38|P-value:1.62E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:2.93|P-value:8.83E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.37|P-value:1.67E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.55|P-value:7.75E-5 ID:SGTC_1827|Compound:berberine|FD-Score:6.36|P-value:5.76E-12 ID:SGTC_1829|Compound:berberine|FD-Score:7.38|P-value:1.85E-15 ID:SGTC_1910|Compound:st062352|FD-Score:3.15|P-value:3.83E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.17|P-value:3.65E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.82|P-value:2.30E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.26|P-value:2.78E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.55|P-value:7.66E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:5.53|P-value:1.82E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:5.30|P-value:7.93E-9 ID:SGTC_2610|Compound:ononetin|FD-Score:5.14|P-value:2.10E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.30|P-value:9.35E-12 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.01|P-value:6.63E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.27|P-value:2.53E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.05|P-value:5.75E-4 ID:SGTC_2899|Compound:9053889|FD-Score:2.96|P-value:7.80E-4 ID:SGTC_3168|Compound:9103419|FD-Score:3.20|P-value:3.21E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.77|P-value:3.06E-5 ID:SGTC_3253|Compound:9135987|FD-Score:2.94|P-value:8.66E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.64|P-value:5.10E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:6.30|P-value:9.44E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:6.07|P-value:4.81E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:6.05|P-value:5.50E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:5.89|P-value:1.67E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:3.61|P-value:5.98E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:5.02|P-value:4.20E-8 ID:SGTC_154|Compound:3389-1638|FD-Score:3.79|P-value:2.67E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:9.67|P-value:3.25E-25 ID:SGTC_165|Compound:k038-0023|FD-Score:3.57|P-value:6.97E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.86|P-value:1.95E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.97|P-value:1.14E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.73|P-value:3.53E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:2.93|P-value:8.99E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.11|P-value:5.80E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.50|P-value:9.46E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.34|P-value:1.88E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.47|P-value:9.49E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:5.03|P-value:4.18E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:4.27|P-value:2.68E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.18|P-value:4.12E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.08|P-value:5.33E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:2.92|P-value:9.23E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:6.29|P-value:1.01E-11 ID:SGTC_846|Compound:0335-0850|FD-Score:3.78|P-value:2.81E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:11.40|P-value:4.37E-34 ID:SGTC_996|Compound:3970-0799|FD-Score:7.57|P-value:3.53E-16 ID:SGTC_1120|Compound:ficusin|FD-Score:2.96|P-value:8.03E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:17.80|P-value:1.01E-80 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.29|P-value:2.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:9.09|P-value:1.69E-22 ID:SGTC_1317|Compound:1273-0028|FD-Score:8.84|P-value:2.13E-21 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.19|P-value:3.98E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.40|P-value:1.42E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.38|P-value:1.62E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:2.93|P-value:8.83E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.37|P-value:1.67E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.55|P-value:7.75E-5 ID:SGTC_1827|Compound:berberine|FD-Score:6.36|P-value:5.76E-12 ID:SGTC_1829|Compound:berberine|FD-Score:7.38|P-value:1.85E-15 ID:SGTC_1910|Compound:st062352|FD-Score:3.15|P-value:3.83E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.17|P-value:3.65E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.82|P-value:2.30E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.26|P-value:2.78E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.55|P-value:7.66E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:5.53|P-value:1.82E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:5.30|P-value:7.93E-9 ID:SGTC_2610|Compound:ononetin|FD-Score:5.14|P-value:2.10E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.30|P-value:9.35E-12 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.01|P-value:6.63E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.27|P-value:2.53E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.05|P-value:5.75E-4 ID:SGTC_2899|Compound:9053889|FD-Score:2.96|P-value:7.80E-4 ID:SGTC_3168|Compound:9103419|FD-Score:3.20|P-value:3.21E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.77|P-value:3.06E-5 ID:SGTC_3253|Compound:9135987|FD-Score:2.94|P-value:8.66E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.64|P-value:5.10E-5

Top fitness defect scores for YMR127C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1121 fusaric acid 17.80 630.5 nM 1.01E-80 3 2.53E-71
2 SGTC_862 0452-0056 11.40 10.2 µM 4.37E-34 azole & statin 2 3.08E-30
3 SGTC_158 k038-0087 9.67 26.4 µM 3.25E-25 ubiquinone biosynthesis & proteasome 32 2.03E-22
4 SGTC_1246 0422-0085 9.09 105.0 µM 1.69E-22 1 5.02E-20
5 SGTC_1317 1273-0028 8.84 910.0 nM 2.13E-21 azole & statin 14 4.70E-19
6 SGTC_996 3970-0799 7.57 1.8 µM 3.53E-16 23 1.88E-14
7 SGTC_1829 berberine 7.38 14.4 µM 1.85E-15 60S ribosome export 1 8.09E-14
8 SGTC_1827 berberine 6.36 7.2 µM 5.76E-12 60S ribosome export 2 9.79E-11
9 SGTC_2616 abietic acid 6.30 100.0 µM 9.35E-12 9 1.50E-10
10 SGTC_36 0335-0881 6.30 14.2 µM 9.44E-12 ubiquinone biosynthesis & proteasome 58 1.51E-10
11 SGTC_794 k038-0031 6.29 316.0 µM 1.01E-11 ubiquinone biosynthesis & proteasome 50 1.61E-10
12 SGTC_64 000l-0018 6.07 272.1 µM 4.81E-11 ubiquinone biosynthesis & proteasome 79 6.38E-10
13 SGTC_67 0335-0847 6.05 266.0 µM 5.50E-11 ubiquinone biosynthesis & proteasome 68 7.18E-10
14 SGTC_86 0417-1630 5.89 471.9 µM 1.67E-10 ubiquinone biosynthesis & proteasome 90 1.91E-9
15 SGTC_2605 digitonin 5.53 300.0 nM 1.82E-9 5 1.57E-8
16 SGTC_2608 thymoquinone 5.30 42.7 µM 7.93E-9 7 5.78E-8
17 SGTC_2610 ononetin 5.14 44.2 µM 2.10E-8 13 1.37E-7
18 SGTC_363 0455-0021 5.03 3.1 µM 4.18E-8 azole & statin 41 2.51E-7
19 SGTC_142 0335-0849 5.02 62.7 µM 4.20E-8 ubiquinone biosynthesis & proteasome 83 2.52E-7
20 SGTC_340 k038-0059 4.47 454.0 µM 9.49E-7 ubiquinone biosynthesis & proteasome 38 3.97E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.633 0 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.407 2.43E-134 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.403 4.19E-131 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.395 5.33E-126 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.376 3.16E-113 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.373 2.12E-111 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.358 2.38E-102 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.347 1.21E-95 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.339 4.51E-91 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.333 1.07E-87 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.328 7.64E-85 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.325 1.32E-83 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.322 8.85E-82 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.318 7.28E-80 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.312 1.06E-76 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation