YMR131C / RRB1

Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR131C / RRB1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:6.63|P-value:2.39E-11 ID:SGTC_100|Compound:0086-0128|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.26|P-value:1.19E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:7.06|P-value:1.24E-12 ID:SGTC_341|Compound:1486-1430|FD-Score:5.41|P-value:3.94E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.14|P-value:8.57E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.81|P-value:8.09E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.28|P-value:5.73E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.48|P-value:2.85E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.29|P-value:5.13E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.27|P-value:5.98E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.28|P-value:9.88E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.27|P-value:5.52E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.33|P-value:6.17E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:6.67|P-value:1.78E-11 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.79|P-value:8.59E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.23|P-value:6.19E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.75|P-value:9.12E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.13|P-value:8.71E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.55|P-value:1.97E-4 ID:SGTC_1706|Compound:st031321|FD-Score:5.46|P-value:3.07E-8 ID:SGTC_1707|Compound:st032323|FD-Score:-3.27|P-value:5.42E-4 ID:SGTC_1746|Compound:st038117|FD-Score:7.21|P-value:4.09E-13 ID:SGTC_1806|Compound:st050005|FD-Score:3.86|P-value:6.55E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.25|P-value:5.86E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.36|P-value:3.90E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.13|P-value:8.91E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.54|P-value:2.03E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.14|P-value:8.40E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.50|P-value:2.36E-4 ID:SGTC_1966|Compound:st070145|FD-Score:5.22|P-value:1.10E-7 ID:SGTC_1970|Compound:st070122|FD-Score:-3.12|P-value:9.03E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.53|P-value:3.61E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.37|P-value:4.29E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.17|P-value:8.46E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.04|P-value:1.00E-9 ID:SGTC_2241|Compound:6772625|FD-Score:-4.31|P-value:8.39E-6 ID:SGTC_2294|Compound:7971431|FD-Score:4.11|P-value:2.34E-5 ID:SGTC_2344|Compound:7990960|FD-Score:5.02|P-value:3.24E-7 ID:SGTC_2372|Compound:9071633|FD-Score:5.25|P-value:9.37E-8 ID:SGTC_2378|Compound:9074213|FD-Score:-4.16|P-value:1.67E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.69|P-value:1.13E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.76|P-value:1.16E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:4.80|P-value:9.48E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.69|P-value:1.16E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.27|P-value:5.45E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.15|P-value:1.98E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.97|P-value:1.32E-9 ID:SGTC_3148|Compound:9097893|FD-Score:3.74|P-value:1.06E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.19|P-value:7.25E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.05|P-value:3.00E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.22|P-value:6.50E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.88|P-value:6.13E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.12|P-value:9.90E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.73|P-value:1.07E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.63|P-value:2.39E-11 ID:SGTC_100|Compound:0086-0128|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.26|P-value:1.19E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:7.06|P-value:1.24E-12 ID:SGTC_341|Compound:1486-1430|FD-Score:5.41|P-value:3.94E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.14|P-value:8.57E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.81|P-value:8.09E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.28|P-value:5.73E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.48|P-value:2.85E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.29|P-value:5.13E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.27|P-value:5.98E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.28|P-value:9.88E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.27|P-value:5.52E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.33|P-value:6.17E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:6.67|P-value:1.78E-11 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.79|P-value:8.59E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.23|P-value:6.19E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.75|P-value:9.12E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.13|P-value:8.71E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.55|P-value:1.97E-4 ID:SGTC_1706|Compound:st031321|FD-Score:5.46|P-value:3.07E-8 ID:SGTC_1707|Compound:st032323|FD-Score:-3.27|P-value:5.42E-4 ID:SGTC_1746|Compound:st038117|FD-Score:7.21|P-value:4.09E-13 ID:SGTC_1806|Compound:st050005|FD-Score:3.86|P-value:6.55E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.25|P-value:5.86E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.36|P-value:3.90E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.13|P-value:8.91E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.54|P-value:2.03E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.14|P-value:8.40E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.50|P-value:2.36E-4 ID:SGTC_1966|Compound:st070145|FD-Score:5.22|P-value:1.10E-7 ID:SGTC_1970|Compound:st070122|FD-Score:-3.12|P-value:9.03E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.53|P-value:3.61E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.37|P-value:4.29E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.17|P-value:8.46E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.04|P-value:1.00E-9 ID:SGTC_2241|Compound:6772625|FD-Score:-4.31|P-value:8.39E-6 ID:SGTC_2294|Compound:7971431|FD-Score:4.11|P-value:2.34E-5 ID:SGTC_2344|Compound:7990960|FD-Score:5.02|P-value:3.24E-7 ID:SGTC_2372|Compound:9071633|FD-Score:5.25|P-value:9.37E-8 ID:SGTC_2378|Compound:9074213|FD-Score:-4.16|P-value:1.67E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.69|P-value:1.13E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.76|P-value:1.16E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:4.80|P-value:9.48E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.69|P-value:1.16E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.27|P-value:5.45E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.15|P-value:1.98E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.97|P-value:1.32E-9 ID:SGTC_3148|Compound:9097893|FD-Score:3.74|P-value:1.06E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-3.19|P-value:7.25E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.05|P-value:3.00E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.22|P-value:6.50E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.88|P-value:6.13E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.12|P-value:9.90E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.73|P-value:1.07E-4

Top fitness defect scores for YMR131C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1746 st038117 7.21 42.0 µM 4.09E-13 1 2.78E-13 1.68
2 SGTC_236 1509-0011 7.06 5.3 µM 1.24E-12 6 8.54E-13 0.29
3 SGTC_1201 1889-3372 6.67 45.9 µM 1.78E-11 Golgi 1 1.27E-11 1.02
4 SGTC_70 0141-0289 6.63 43.3 µM 2.39E-11 mitochondrial stress 10 1.71E-11 1.08
5 SGTC_2233 sulbentine 6.04 40.4 µM 1.00E-9 23 7.54E-10 0.51
6 SGTC_1706 st031321 5.46 10.0 µM 3.07E-8 TSC3-RPN4 1 2.40E-8 1.47
7 SGTC_341 1486-1430 5.41 230.0 µM 3.94E-8 10 3.10E-8 0.17
8 SGTC_1188 1403-0014 5.33 4.6 µM 6.17E-8 mitochondrial stress 8 4.88E-8 0.70
9 SGTC_2372 9071633 5.25 200.0 µM 9.37E-8 1 7.45E-8 1.59
10 SGTC_1966 st070145 5.22 16.1 µM 1.10E-7 3 8.74E-8 0.98
11 SGTC_2344 7990960 5.02 77.0 µM 3.24E-7 26 2.62E-7 0.28
12 SGTC_2607 solasodine 4.80 47.4 µM 9.48E-7 7 7.77E-7 0.27
13 SGTC_2408 sulbentine 4.76 18.4 µM 1.16E-6 24 9.57E-7 0.14
14 SGTC_1997 st073024 4.53 93.8 µM 3.61E-6 2 3.02E-6 0.55
15 SGTC_173 1273-0061 4.26 2.7 µM 1.19E-5 mitochondrial stress 23 1.01E-5 0.01
16 SGTC_2944 9067346 4.15 25.6 µM 1.98E-5 12 1.69E-5 0.20
17 SGTC_2294 7971431 4.11 200.0 µM 2.34E-5 5 2.00E-5 0.67
18 SGTC_3190 9110366 4.05 49.5 µM 3.00E-5 2 2.58E-5 0.12
19 SGTC_3312 9133330 3.88 71.4 µM 6.13E-5 5 5.32E-5 0.31
20 SGTC_1806 st050005 3.86 60.3 µM 6.55E-5 2 5.68E-5 0.52

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 3.16E-45 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.221 1.74E-38 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.204 6.75E-33 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.203 1.36E-32 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.201 8.48E-32 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.199 2.32E-31 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.194 6.89E-30 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.193 1.28E-29 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.193 1.56E-29 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.192 3.25E-29 YDL068W_d YDL068W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.191 7.45E-29 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.189 2.05E-28 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.188 3.87E-28 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.188 5.04E-28 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.188 5.14E-28 YJR144W MGM101 hom Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage