YMR133W / REC114

Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR133W / REC114

Click on Significant Values for Screen Details ID:SGTC_300|Compound:r073-0011|FD-Score:-2.79|P-value:7.40E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:-2.74|P-value:8.99E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.48|P-value:3.58E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.38|P-value:5.69E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.74|P-value:8.86E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.90|P-value:4.80E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.95|P-value:2.95E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.81|P-value:5.26E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.55|P-value:1.89E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.28|P-value:6.82E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.39|P-value:1.78E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:3.30|P-value:6.31E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:5.10|P-value:1.73E-9 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.45|P-value:4.10E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.80|P-value:5.50E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.43|P-value:3.36E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.38|P-value:4.21E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.90|P-value:4.79E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.14|P-value:1.33E-9 ID:SGTC_1521|Compound:st012942|FD-Score:2.65|P-value:9.98E-4 ID:SGTC_1662|Compound:st014054|FD-Score:-2.72|P-value:9.56E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-2.76|P-value:8.42E-4 ID:SGTC_1669|Compound:st015249|FD-Score:-3.75|P-value:9.03E-6 ID:SGTC_1696|Compound:st025591|FD-Score:-3.00|P-value:3.15E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.98|P-value:1.95E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-2.87|P-value:5.47E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-2.82|P-value:6.45E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.04|P-value:2.02E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.34|P-value:1.07E-13 ID:SGTC_2692|Compound:st077426|FD-Score:4.70|P-value:2.62E-8 ID:SGTC_2693|Compound:st077581|FD-Score:6.05|P-value:1.29E-12 ID:SGTC_2785|Compound:7756463|FD-Score:-3.15|P-value:1.63E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.69|P-value:2.65E-8 ID:SGTC_2794|Compound:7785382|FD-Score:4.30|P-value:3.13E-7 ID:SGTC_2918|Compound:7977171|FD-Score:2.85|P-value:4.46E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.67|P-value:9.18E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.66|P-value:9.62E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.79|P-value:7.40E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:-2.74|P-value:8.99E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.48|P-value:3.58E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.38|P-value:5.69E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.74|P-value:8.86E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.90|P-value:4.80E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.95|P-value:2.95E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.81|P-value:5.26E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.55|P-value:1.89E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.28|P-value:6.82E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.39|P-value:1.78E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:3.30|P-value:6.31E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:5.10|P-value:1.73E-9 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.45|P-value:4.10E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.80|P-value:5.50E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.43|P-value:3.36E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.38|P-value:4.21E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.90|P-value:4.79E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.14|P-value:1.33E-9 ID:SGTC_1521|Compound:st012942|FD-Score:2.65|P-value:9.98E-4 ID:SGTC_1662|Compound:st014054|FD-Score:-2.72|P-value:9.56E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-2.76|P-value:8.42E-4 ID:SGTC_1669|Compound:st015249|FD-Score:-3.75|P-value:9.03E-6 ID:SGTC_1696|Compound:st025591|FD-Score:-3.00|P-value:3.15E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.98|P-value:1.95E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-2.87|P-value:5.47E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-2.82|P-value:6.45E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.04|P-value:2.02E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.34|P-value:1.07E-13 ID:SGTC_2692|Compound:st077426|FD-Score:4.70|P-value:2.62E-8 ID:SGTC_2693|Compound:st077581|FD-Score:6.05|P-value:1.29E-12 ID:SGTC_2785|Compound:7756463|FD-Score:-3.15|P-value:1.63E-4 ID:SGTC_2791|Compound:5663188|FD-Score:4.69|P-value:2.65E-8 ID:SGTC_2794|Compound:7785382|FD-Score:4.30|P-value:3.13E-7 ID:SGTC_2918|Compound:7977171|FD-Score:2.85|P-value:4.46E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.67|P-value:9.18E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.66|P-value:9.62E-4

Top fitness defect scores for YMR133W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2691 st077356 6.34 60.2 µM 1.07E-13 3 1.13E-10
2 SGTC_2693 st077581 6.05 40.7 µM 1.29E-12 6 7.42E-10
3 SGTC_1379 2144-0755 5.14 36.5 µM 1.33E-9 9 1.40E-7
4 SGTC_916 4466-0038 5.10 42.0 nM 1.73E-9 cell wall 37 1.71E-7
5 SGTC_2692 st077426 4.70 47.7 µM 2.62E-8 9 1.33E-6
6 SGTC_2791 5663188 4.69 71.4 µM 2.65E-8 RPP1 & pyrimidine depletion 8 1.34E-6
7 SGTC_807 1315-0151 4.39 48.0 µM 1.78E-7 16 5.66E-6
8 SGTC_2794 7785382 4.30 27.3 µM 3.13E-7 24 8.70E-6
9 SGTC_1739 st037196 3.98 92.5 µM 1.95E-6 22 3.47E-5
10 SGTC_797 k781-0471 3.55 270.0 µM 1.89E-5 RPP1 & pyrimidine depletion 35 1.95E-4
11 SGTC_1248 0469-0687 3.43 58.6 µM 3.36E-5 50 3.01E-4
12 SGTC_1270 0831-1170 3.38 17.3 µM 4.21E-5 23 3.58E-4
13 SGTC_910 3454-3003 3.30 490.0 µM 6.31E-5 37 4.87E-4
14 SGTC_798 1287-0182 3.28 476.0 µM 6.82E-5 50 5.16E-4
15 SGTC_2407 paclitaxel 3.04 400.0 µM 2.02E-4 82 0.00118
16 SGTC_763 3453-1109 2.95 128.0 µM 2.95E-4 57 0.00157
17 SGTC_2918 7977171 2.85 22.1 µM 4.46E-4 68 0.00216
18 SGTC_784 4579-0127 2.81 173.0 µM 5.26E-4 82 0.00245
19 SGTC_1246 0422-0085 2.80 105.0 µM 5.50E-4 101 0.00253
20 SGTC_3297 9117502 2.67 71.4 µM 9.18E-4 59 0.00374

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 1.38E-46 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.240 2.48E-45 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.187 9.28E-28 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.184 4.66E-27 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.183 1.11E-26 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.182 2.02E-26 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.177 6.12E-25 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.177 6.23E-25 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.176 7.90E-25 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.175 1.35E-24 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.174 2.32E-24 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.167 2.00E-22 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.163 2.04E-21 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.162 3.01E-21 YMR164C MSS11 hom Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
0.159 1.94E-20 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene