YMR137C / PSO2

Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR137C / PSO2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.20|P-value:1.28E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.87|P-value:5.16E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.39|P-value:5.24E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.33|P-value:4.29E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:9.48|P-value:1.82E-27 ID:SGTC_354|Compound:2783-3500|FD-Score:4.38|P-value:3.14E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.15|P-value:1.58E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.39|P-value:5.93E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.20|P-value:1.26E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.46|P-value:4.17E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.96|P-value:3.54E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.84|P-value:5.83E-6 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.09|P-value:2.21E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.00|P-value:3.25E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.83|P-value:6.60E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.48|P-value:3.89E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.17|P-value:1.56E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.26|P-value:5.86E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.07|P-value:3.43E-16 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.30|P-value:3.12E-13 ID:SGTC_1613|Compound:st002381|FD-Score:-3.58|P-value:2.14E-5 ID:SGTC_1669|Compound:st015249|FD-Score:-2.89|P-value:4.70E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.62|P-value:7.49E-8 ID:SGTC_1728|Compound:st035614|FD-Score:5.02|P-value:5.58E-9 ID:SGTC_1838|Compound:st055369|FD-Score:-2.73|P-value:9.14E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.79|P-value:7.74E-4 ID:SGTC_2020|Compound:4017018|FD-Score:2.78|P-value:7.88E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.79|P-value:7.17E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.81|P-value:7.31E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.61|P-value:2.05E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.78|P-value:7.92E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.59|P-value:9.01E-8 ID:SGTC_2931|Compound:9014674|FD-Score:-3.23|P-value:1.11E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.00|P-value:2.96E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.20|P-value:1.28E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.87|P-value:5.16E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.39|P-value:5.24E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.33|P-value:4.29E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:9.48|P-value:1.82E-27 ID:SGTC_354|Compound:2783-3500|FD-Score:4.38|P-value:3.14E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.15|P-value:1.58E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.39|P-value:5.93E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.20|P-value:1.26E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.46|P-value:4.17E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.96|P-value:3.54E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.84|P-value:5.83E-6 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.09|P-value:2.21E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.00|P-value:3.25E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.83|P-value:6.60E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.48|P-value:3.89E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.17|P-value:1.56E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.26|P-value:5.86E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.07|P-value:3.43E-16 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.30|P-value:3.12E-13 ID:SGTC_1613|Compound:st002381|FD-Score:-3.58|P-value:2.14E-5 ID:SGTC_1669|Compound:st015249|FD-Score:-2.89|P-value:4.70E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.62|P-value:7.49E-8 ID:SGTC_1728|Compound:st035614|FD-Score:5.02|P-value:5.58E-9 ID:SGTC_1838|Compound:st055369|FD-Score:-2.73|P-value:9.14E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.79|P-value:7.74E-4 ID:SGTC_2020|Compound:4017018|FD-Score:2.78|P-value:7.88E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.79|P-value:7.17E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.81|P-value:7.31E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.61|P-value:2.05E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.78|P-value:7.92E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:4.59|P-value:9.01E-8 ID:SGTC_2931|Compound:9014674|FD-Score:-3.23|P-value:1.11E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.00|P-value:2.96E-4

Top fitness defect scores for YMR137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_247 mechlorethamine 9.48 29.7 µM 1.82E-27 DNA damage response 1 1.25E-21
2 SGTC_1728 st035614 5.02 33.8 µM 5.58E-9 21 2.56E-7
3 SGTC_1727 st034309 4.62 9.9 µM 7.49E-8 18 1.93E-6
4 SGTC_2677 mitomycin C 4.59 100.0 µM 9.01E-8 DNA damage response 11 2.23E-6
5 SGTC_354 2783-3500 4.38 4.9 µM 3.14E-7 cell wall 37 5.88E-6
6 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.33 819.4 µM 4.29E-7 heat shock/prefoldin 29 7.52E-6
7 SGTC_2285 7945142 3.81 200.0 µM 7.31E-6 26 6.87E-5
8 SGTC_2306 7482397 3.61 179.5 µM 2.05E-5 RPP1 & pyrimidine depletion 32 1.54E-4
9 SGTC_1291 0993-0025 3.48 5.8 µM 3.89E-5 15 2.54E-4
10 SGTC_865 0488-0499 3.46 301.0 µM 4.17E-5 31 2.68E-4
11 SGTC_439 amiodarone 3.39 34.4 µM 5.93E-5 NEO1-PIK1 121 3.53E-4
12 SGTC_1359 1582-0056 3.17 520.0 nM 1.56E-4 49 7.55E-4
13 SGTC_1143 3454-2408 3.09 5.1 µM 2.21E-4 60S ribosome export 16 9.91E-4
14 SGTC_1177 0983-0204 3.00 23.6 µM 3.25E-4 47 0.00134
15 SGTC_1262 0737-0114 2.83 49.6 µM 6.60E-4 80 0.00234
16 SGTC_2014 4013930 2.79 200.0 µM 7.74E-4 111 0.00266
17 SGTC_2020 4017018 2.78 200.0 µM 7.88E-4 84 0.00270
18 SGTC_2519 cryptotanshinone 2.78 88.0 µM 7.92E-4 heme biosynthesis & mitochondrial translocase 60 0.00270
19 SGTC_333 3486-0131 2.71 40.1 µM 0.00104 amide catabolism 58 0.00335
20 SGTC_1644 st010134 2.68 20.9 µM 0.00119 mitochondrial processes 63 0.00372

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.374 8.62E-112 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.348 1.94E-96 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.324 2.75E-82 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.321 5.22E-81 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.305 5.09E-73 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.288 5.64E-65 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.284 1.78E-63 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.282 3.27E-62 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.274 6.10E-59 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.258 4.65E-52 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.242 4.99E-46 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.236 8.77E-44 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.233 2.14E-42 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.231 1.03E-41 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.230 1.14E-41 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress