YMR138W / CIN4

GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR138W / CIN4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.84|P-value:1.26E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.14|P-value:3.94E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.24|P-value:0.00100 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.34|P-value:1.84E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:3.50|P-value:4.21E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:18.50|P-value:1.22E-69 ID:SGTC_71|Compound:0417-1750|FD-Score:4.05|P-value:5.66E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.64|P-value:2.67E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.25|P-value:2.84E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.63|P-value:5.10E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:16.60|P-value:2.35E-56 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.67|P-value:3.32E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:4.64|P-value:4.89E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:5.85|P-value:1.26E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:8.62|P-value:1.08E-16 ID:SGTC_229|Compound:benomyl|FD-Score:12.00|P-value:2.45E-30 ID:SGTC_236|Compound:1509-0011|FD-Score:18.10|P-value:3.39E-67 ID:SGTC_275|Compound:trichlorophene|FD-Score:15.00|P-value:2.50E-46 ID:SGTC_310|Compound:1273-0058|FD-Score:3.57|P-value:3.31E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.08|P-value:6.62E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:9.83|P-value:3.84E-21 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.35|P-value:7.21E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.44|P-value:5.31E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.20|P-value:3.66E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.29|P-value:8.80E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-5.21|P-value:3.46E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:6.65|P-value:1.21E-10 ID:SGTC_600|Compound:1495-0418|FD-Score:3.34|P-value:7.31E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.84|P-value:1.25E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.40|P-value:6.05E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.53|P-value:3.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.42|P-value:1.19E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.78|P-value:1.61E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.30|P-value:8.40E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.69|P-value:2.21E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.40|P-value:6.00E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.45|P-value:5.09E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.70|P-value:2.14E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.63|P-value:2.69E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.52|P-value:8.34E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.50|P-value:9.12E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:-4.14|P-value:4.14E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.53|P-value:3.85E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.30|P-value:8.45E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.03|P-value:6.24E-5 ID:SGTC_1635|Compound:st007035|FD-Score:17.50|P-value:1.68E-62 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.22|P-value:3.40E-7 ID:SGTC_1796|Compound:st049173|FD-Score:4.46|P-value:1.06E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:8.17|P-value:3.48E-15 ID:SGTC_1930|Compound:st074634|FD-Score:-4.78|P-value:2.69E-6 ID:SGTC_1943|Compound:st076331|FD-Score:3.61|P-value:2.92E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.30|P-value:8.34E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.99|P-value:7.31E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.37|P-value:6.63E-4 ID:SGTC_2174|Compound:5790901|FD-Score:10.90|P-value:2.22E-25 ID:SGTC_2319|Compound:6033012|FD-Score:8.32|P-value:1.11E-15 ID:SGTC_2322|Compound:7413319|FD-Score:-3.67|P-value:2.39E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.41|P-value:5.89E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.90|P-value:1.04E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.93|P-value:8.95E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-5.20|P-value:3.70E-7 ID:SGTC_2793|Compound:7325131|FD-Score:-3.80|P-value:1.46E-4 ID:SGTC_2796|Compound:7949634|FD-Score:5.63|P-value:4.02E-8 ID:SGTC_2800|Compound:7887935|FD-Score:-3.34|P-value:7.27E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.51|P-value:4.20E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.70|P-value:2.17E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.48|P-value:9.81E-6 ID:SGTC_3196|Compound:9111891|FD-Score:3.38|P-value:6.36E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.19|P-value:3.26E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.84|P-value:1.26E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.14|P-value:3.94E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.24|P-value:0.00100 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.34|P-value:1.84E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:3.50|P-value:4.21E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:18.50|P-value:1.22E-69 ID:SGTC_71|Compound:0417-1750|FD-Score:4.05|P-value:5.66E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.64|P-value:2.67E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.25|P-value:2.84E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.63|P-value:5.10E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:16.60|P-value:2.35E-56 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.67|P-value:3.32E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:4.64|P-value:4.89E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:5.85|P-value:1.26E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:8.62|P-value:1.08E-16 ID:SGTC_229|Compound:benomyl|FD-Score:12.00|P-value:2.45E-30 ID:SGTC_236|Compound:1509-0011|FD-Score:18.10|P-value:3.39E-67 ID:SGTC_275|Compound:trichlorophene|FD-Score:15.00|P-value:2.50E-46 ID:SGTC_310|Compound:1273-0058|FD-Score:3.57|P-value:3.31E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.08|P-value:6.62E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:9.83|P-value:3.84E-21 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.35|P-value:7.21E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.44|P-value:5.31E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.20|P-value:3.66E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.29|P-value:8.80E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-5.21|P-value:3.46E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:6.65|P-value:1.21E-10 ID:SGTC_600|Compound:1495-0418|FD-Score:3.34|P-value:7.31E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.84|P-value:1.25E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.40|P-value:6.05E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.53|P-value:3.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.42|P-value:1.19E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.78|P-value:1.61E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.30|P-value:8.40E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.69|P-value:2.21E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.40|P-value:6.00E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.45|P-value:5.09E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.70|P-value:2.14E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.63|P-value:2.69E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.52|P-value:8.34E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.50|P-value:9.12E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:-4.14|P-value:4.14E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.53|P-value:3.85E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.30|P-value:8.45E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.03|P-value:6.24E-5 ID:SGTC_1635|Compound:st007035|FD-Score:17.50|P-value:1.68E-62 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.22|P-value:3.40E-7 ID:SGTC_1796|Compound:st049173|FD-Score:4.46|P-value:1.06E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:8.17|P-value:3.48E-15 ID:SGTC_1930|Compound:st074634|FD-Score:-4.78|P-value:2.69E-6 ID:SGTC_1943|Compound:st076331|FD-Score:3.61|P-value:2.92E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.30|P-value:8.34E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.99|P-value:7.31E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.37|P-value:6.63E-4 ID:SGTC_2174|Compound:5790901|FD-Score:10.90|P-value:2.22E-25 ID:SGTC_2319|Compound:6033012|FD-Score:8.32|P-value:1.11E-15 ID:SGTC_2322|Compound:7413319|FD-Score:-3.67|P-value:2.39E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.41|P-value:5.89E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.90|P-value:1.04E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.93|P-value:8.95E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-5.20|P-value:3.70E-7 ID:SGTC_2793|Compound:7325131|FD-Score:-3.80|P-value:1.46E-4 ID:SGTC_2796|Compound:7949634|FD-Score:5.63|P-value:4.02E-8 ID:SGTC_2800|Compound:7887935|FD-Score:-3.34|P-value:7.27E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.51|P-value:4.20E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.70|P-value:2.17E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.48|P-value:9.81E-6 ID:SGTC_3196|Compound:9111891|FD-Score:3.38|P-value:6.36E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.19|P-value:3.26E-5

Top fitness defect scores for YMR138W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 18.50 43.3 µM 1.22E-69 mitochondrial stress 4 1.46E-76
2 SGTC_236 1509-0011 18.10 5.3 µM 3.39E-67 68 7.23E-74
3 SGTC_1635 st007035 17.50 42.4 µM 1.68E-62 26 1.08E-68
4 SGTC_149 3970-0822 16.60 46.1 µM 2.35E-56 tubulin folding & SWR complex 2 6.46E-62
5 SGTC_275 trichlorophene 15.00 5.7 µM 2.50E-46 mitochondrial stress 8 7.25E-51
6 SGTC_229 benomyl 12.00 22.9 µM 2.45E-30 tubulin folding & SWR complex 9 3.04E-33
7 SGTC_2174 5790901 10.90 200.0 µM 2.22E-25 tubulin folding & SWR complex 8 8.83E-28
8 SGTC_386 1509-0011 9.83 3.1 µM 3.84E-21 47 4.11E-23
9 SGTC_212 3807-4682 8.62 38.8 µM 1.08E-16 tubulin folding & SWR complex 13 3.26E-18
10 SGTC_2319 6033012 8.32 152.6 µM 1.11E-15 tubulin folding & SWR complex 10 4.26E-17
11 SGTC_1875 nocodazole 8.17 6.0 µM 3.48E-15 tubulin folding & SWR complex 17 1.49E-16
12 SGTC_503 tyrphostin 8 6.65 294.0 µM 1.21E-10 TSC3-RPN4 3 1.48E-11
13 SGTC_210 3551-0445 5.85 56.8 µM 1.26E-8 27 2.47E-9
14 SGTC_2796 7949634 5.63 45.5 µM 4.02E-8 7 8.81E-9
15 SGTC_908 3448-7491 5.42 47.7 µM 1.19E-7 mitochondrial stress 62 2.91E-8
16 SGTC_100 0086-0128 5.25 49.6 µM 2.84E-7 copper-dependent oxidative stress 19 7.56E-8
17 SGTC_365 0121-0052 5.08 13.6 µM 6.62E-7 mitochondrial response to ROS 30 1.92E-7
18 SGTC_173 1273-0061 4.64 2.7 µM 4.89E-6 mitochondrial stress 162 1.72E-6
19 SGTC_134 0269-0018 4.63 6.9 µM 5.10E-6 108 1.81E-6
20 SGTC_1326 1431-2094 4.52 10.8 µM 8.34E-6 tubulin folding & SWR complex 23 3.10E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.535 1.10E-247 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.523 1.28E-234 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.520 2.54E-232 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.516 1.32E-227 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.514 2.33E-225 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.513 1.34E-224 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.506 8.77E-218 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.501 1.32E-212 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.492 5.58E-204 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.491 4.78E-203 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.486 8.91E-199 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.471 9.66E-185 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.458 1.65E-173 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.456 1.16E-171 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.454 2.22E-170 YJR144W MGM101 hom Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage