YMR141C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR141C / YMR141C

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.36|P-value:8.38E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.65|P-value:2.18E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.61|P-value:1.77E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.76|P-value:1.03E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.27|P-value:6.29E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.64|P-value:1.65E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.34|P-value:4.94E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.26|P-value:6.40E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.19|P-value:8.29E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.24|P-value:1.40E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.93|P-value:5.07E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.70|P-value:1.27E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.64|P-value:1.64E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.39|P-value:4.14E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.38|P-value:4.21E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.39|P-value:7.13E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.23|P-value:7.20E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.16|P-value:9.17E-4 ID:SGTC_2100|Compound:5377183|FD-Score:4.23|P-value:1.47E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.76|P-value:1.00E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.47|P-value:3.06E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-4.75|P-value:1.31E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.31|P-value:5.34E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.76|P-value:1.04E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.51|P-value:2.54E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.65|P-value:1.51E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.47|P-value:5.12E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.83|P-value:7.79E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.36|P-value:4.41E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.21|P-value:7.65E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.00|P-value:3.99E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.51|P-value:4.03E-6 ID:SGTC_2992|Compound:9074591|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.25|P-value:6.77E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.20|P-value:7.85E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.30|P-value:5.56E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.36|P-value:8.38E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.65|P-value:2.18E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.61|P-value:1.77E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.76|P-value:1.03E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.27|P-value:6.29E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.64|P-value:1.65E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.34|P-value:4.94E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.26|P-value:6.40E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.19|P-value:8.29E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.24|P-value:1.40E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.93|P-value:5.07E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.70|P-value:1.27E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.64|P-value:1.64E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.39|P-value:4.14E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.38|P-value:4.21E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.39|P-value:7.13E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.23|P-value:7.20E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.16|P-value:9.17E-4 ID:SGTC_2100|Compound:5377183|FD-Score:4.23|P-value:1.47E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.76|P-value:1.00E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.47|P-value:3.06E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-4.75|P-value:1.31E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.31|P-value:5.34E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.76|P-value:1.04E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.51|P-value:2.54E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.65|P-value:1.51E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.47|P-value:5.12E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.83|P-value:7.79E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.36|P-value:4.41E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.21|P-value:7.65E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.00|P-value:3.99E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.51|P-value:4.03E-6 ID:SGTC_2992|Compound:9074591|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.25|P-value:6.77E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.20|P-value:7.85E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.30|P-value:5.56E-4

Top fitness defect scores for YMR141C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2600 tangeritin 5.00 88.0 µM 3.99E-7 13 2.90E-7
2 SGTC_2422 chlorphenesin carbamate 4.47 384.2 µM 5.12E-6 18 3.96E-6
3 SGTC_1760 st045453 4.39 10.4 µM 7.13E-6 NEO1-PIK1 129 5.55E-6
4 SGTC_76 0433-0009 4.36 400.3 µM 8.38E-6 8 6.55E-6
5 SGTC_1130 3454-2858 4.24 15.9 µM 1.40E-5 NEO1 72 1.11E-5
6 SGTC_2100 5377183 4.23 190.0 µM 1.47E-5 60S ribosome export 9 1.16E-5
7 SGTC_2528 xanthyletin 3.83 44.8 µM 7.79E-5 25 6.42E-5
8 SGTC_361 000s-0510 3.76 1.4 µM 1.03E-4 35 8.50E-5
9 SGTC_2155 5570423 3.76 76.0 µM 1.04E-4 ergosterol biosynthesis 14 8.60E-5
10 SGTC_2992 9074591 3.66 71.4 µM 1.53E-4 19 1.28E-4
11 SGTC_1442 4112-3290 3.64 3.0 µM 1.64E-4 21 1.37E-4
12 SGTC_653 0203-0016 3.64 55.2 µM 1.65E-4 26 1.39E-4
13 SGTC_3346 9158254 3.52 43.6 µM 2.57E-4 32 2.17E-4
14 SGTC_2108 5365811 3.47 200.0 µM 3.06E-4 33 2.60E-4
15 SGTC_1726 st035556 3.39 14.6 µM 4.14E-4 62 3.54E-4
16 SGTC_1748 st037455 3.38 53.6 µM 4.21E-4 52 3.60E-4
17 SGTC_771 0250-0039 3.34 27.3 µM 4.94E-4 28 4.25E-4
18 SGTC_675 1309-0189 3.33 238.0 µM 5.00E-4 24 4.30E-4
19 SGTC_48 0382-0018 3.32 55.0 µM 5.24E-4 24 4.51E-4
20 SGTC_2117 5521686 3.31 200.0 µM 5.34E-4 32 4.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.89E-11 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.109 2.19E-10 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.109 2.87E-10 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.108 3.27E-10 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.107 5.63E-10 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.106 7.25E-10 YOR173W DCS2 hom Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
0.093 7.85E-8 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.092 9.76E-8 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.088 3.40E-7 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.087 4.57E-7 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.085 8.14E-7 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.083 1.46E-6 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.73E-6 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.78E-6 YJL194W CDC6 het Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.081 2.35E-6 YKR081C RPF2 het Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles