YMR142C / RPL13B

Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR142C / RPL13B

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:5.03|P-value:6.88E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:4.76|P-value:2.48E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:3.52|P-value:3.74E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.20|P-value:2.78E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:5.00|P-value:7.98E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:8.71|P-value:2.59E-17 ID:SGTC_343|Compound:4130-2827|FD-Score:4.41|P-value:1.17E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.04|P-value:5.27E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.89|P-value:9.36E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.95|P-value:7.71E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.33|P-value:1.64E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.66|P-value:2.26E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.30|P-value:7.87E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.24|P-value:9.96E-10 ID:SGTC_501|Compound:nsc-95397|FD-Score:5.64|P-value:2.99E-8 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:7.42|P-value:4.74E-13 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.22|P-value:2.07E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.28|P-value:7.13E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.24|P-value:9.50E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.66|P-value:3.84E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.77|P-value:1.48E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.86|P-value:1.07E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.22|P-value:8.71E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.48|P-value:4.24E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.43|P-value:5.00E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.67|P-value:3.74E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:6.57|P-value:1.36E-10 ID:SGTC_831|Compound:k061-1017|FD-Score:5.06|P-value:5.84E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.61|P-value:4.83E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.48|P-value:3.61E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-5.24|P-value:1.86E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.63|P-value:2.49E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.87|P-value:1.02E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.25|P-value:9.11E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.45|P-value:4.71E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.47|P-value:4.44E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.58|P-value:3.02E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.65|P-value:7.95E-11 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.01|P-value:7.65E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.29|P-value:8.17E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.98|P-value:6.76E-5 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-3.37|P-value:5.34E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:5.46|P-value:7.67E-8 ID:SGTC_1558|Compound:st069300|FD-Score:-4.98|P-value:6.73E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.59|P-value:2.90E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.20|P-value:2.34E-5 ID:SGTC_1837|Compound:st055472|FD-Score:-3.29|P-value:6.91E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.60|P-value:2.77E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.53|P-value:3.02E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.62|P-value:2.57E-4 ID:SGTC_2102|Compound:5377816|FD-Score:5.35|P-value:1.40E-7 ID:SGTC_2187|Compound:6125751|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.39|P-value:5.88E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.22|P-value:2.69E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.25|P-value:2.31E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.73|P-value:2.76E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.42|P-value:5.33E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.73|P-value:1.48E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.25|P-value:9.13E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.36|P-value:6.50E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.33|P-value:1.18E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.48|P-value:3.59E-4 ID:SGTC_2792|Compound:7535235|FD-Score:7.48|P-value:3.14E-13 ID:SGTC_2800|Compound:7887935|FD-Score:4.05|P-value:5.17E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_2802|Compound:7925815|FD-Score:5.95|P-value:5.48E-9 ID:SGTC_2827|Compound:7993847|FD-Score:6.34|P-value:5.55E-10 ID:SGTC_2959|Compound:9079155|FD-Score:4.18|P-value:3.07E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.28|P-value:8.27E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.69|P-value:1.69E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.32|P-value:6.20E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.03|P-value:6.88E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:4.76|P-value:2.48E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:3.52|P-value:3.74E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.20|P-value:2.78E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:5.00|P-value:7.98E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:8.71|P-value:2.59E-17 ID:SGTC_343|Compound:4130-2827|FD-Score:4.41|P-value:1.17E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.04|P-value:5.27E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.89|P-value:9.36E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.95|P-value:7.71E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.33|P-value:1.64E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.66|P-value:2.26E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.30|P-value:7.87E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.24|P-value:9.96E-10 ID:SGTC_501|Compound:nsc-95397|FD-Score:5.64|P-value:2.99E-8 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:7.42|P-value:4.74E-13 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.22|P-value:2.07E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.28|P-value:7.13E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.24|P-value:9.50E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.66|P-value:3.84E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.77|P-value:1.48E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.86|P-value:1.07E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.22|P-value:8.71E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.48|P-value:4.24E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.43|P-value:5.00E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.67|P-value:3.74E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:6.57|P-value:1.36E-10 ID:SGTC_831|Compound:k061-1017|FD-Score:5.06|P-value:5.84E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.61|P-value:4.83E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.48|P-value:3.61E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-5.24|P-value:1.86E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.63|P-value:2.49E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.87|P-value:1.02E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.25|P-value:9.11E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.45|P-value:4.71E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.47|P-value:4.44E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.58|P-value:3.02E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.65|P-value:7.95E-11 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.01|P-value:7.65E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.29|P-value:8.17E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.98|P-value:6.76E-5 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-3.37|P-value:5.34E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:5.46|P-value:7.67E-8 ID:SGTC_1558|Compound:st069300|FD-Score:-4.98|P-value:6.73E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.59|P-value:2.90E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.20|P-value:2.34E-5 ID:SGTC_1837|Compound:st055472|FD-Score:-3.29|P-value:6.91E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.60|P-value:2.77E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.53|P-value:3.02E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.62|P-value:2.57E-4 ID:SGTC_2102|Compound:5377816|FD-Score:5.35|P-value:1.40E-7 ID:SGTC_2187|Compound:6125751|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.39|P-value:5.88E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.22|P-value:2.69E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.25|P-value:2.31E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.73|P-value:2.76E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.42|P-value:5.33E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.73|P-value:1.48E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.25|P-value:9.13E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.36|P-value:6.50E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.33|P-value:1.18E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.48|P-value:3.59E-4 ID:SGTC_2792|Compound:7535235|FD-Score:7.48|P-value:3.14E-13 ID:SGTC_2800|Compound:7887935|FD-Score:4.05|P-value:5.17E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_2802|Compound:7925815|FD-Score:5.95|P-value:5.48E-9 ID:SGTC_2827|Compound:7993847|FD-Score:6.34|P-value:5.55E-10 ID:SGTC_2959|Compound:9079155|FD-Score:4.18|P-value:3.07E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.28|P-value:8.27E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.69|P-value:1.69E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.32|P-value:6.20E-4

Top fitness defect scores for YMR142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_341 1486-1430 8.71 230.0 µM 2.59E-17 1 1.51E-18
2 SGTC_2792 7535235 7.48 81.8 µM 3.14E-13 fatty acid desaturase (OLE1) 4 3.73E-14
3 SGTC_503 tyrphostin 8 7.42 294.0 µM 4.74E-13 TSC3-RPN4 2 5.83E-14
4 SGTC_1534 6-azauridine 6.65 81.6 µM 7.95E-11 RNA pol III & RNase P/MRP 5 1.44E-11
5 SGTC_830 4076-0286 6.57 57.8 µM 1.36E-10 translation 9 2.57E-11
6 SGTC_2827 7993847 6.34 71.4 µM 5.55E-10 2 1.17E-10
7 SGTC_451 chloral hydrate 6.24 100.0 µM 9.96E-10 14 2.19E-10
8 SGTC_2802 7925815 5.95 54.5 µM 5.48E-9 6 1.37E-9
9 SGTC_501 nsc-95397 5.64 161.0 µM 2.99E-8 1 8.52E-9
10 SGTC_1549 4'-methoxyflavonol 5.46 74.6 µM 7.67E-8 1 2.35E-8
11 SGTC_2102 5377816 5.35 72.8 µM 1.40E-7 4 4.48E-8
12 SGTC_2589 lobaric acid 5.22 100.0 µM 2.69E-7 11 9.05E-8
13 SGTC_831 k061-1017 5.06 217.0 µM 5.84E-7 translation 21 2.08E-7
14 SGTC_103 0844-0104 5.03 51.8 µM 6.88E-7 ERAD & cell cycle 101 2.49E-7
15 SGTC_1542 7-hydroxy-3'-methoxyflavone 5.01 49.7 µM 7.65E-7 6 2.79E-7
16 SGTC_325 2810-4341 5.00 181.0 µM 7.98E-7 amide catabolism 3 2.92E-7
17 SGTC_118 0083-0097 4.76 135.3 µM 2.48E-6 translation 72 9.89E-7
18 SGTC_2634 4'-methoxyflavone 4.73 100.0 µM 2.76E-6 15 1.11E-6
19 SGTC_800 3448-7362 4.67 155.0 µM 3.74E-6 translation 105 1.54E-6
20 SGTC_684 1140-0066 4.66 328.0 µM 3.84E-6 Golgi 10 1.58E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.54E-19 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.148 5.69E-18 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.134 7.38E-15 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.130 4.42E-14 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.129 6.38E-14 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.124 5.59E-13 YGL218W_d YGL218W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance
0.123 7.26E-13 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.122 1.28E-12 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.116 1.95E-11 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.115 2.23E-11 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.113 5.00E-11 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.113 5.30E-11 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.113 6.08E-11 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.112 6.95E-11 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.111 9.57E-11 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog