YMR144W_p

Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR144W / YMR144W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.11|P-value:9.44E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:8.07|P-value:9.65E-17 ID:SGTC_369|Compound:0957-0393|FD-Score:3.12|P-value:7.21E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.37|P-value:2.99E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.11|P-value:7.66E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.91|P-value:3.30E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.21|P-value:8.94E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:4.23|P-value:7.95E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.84|P-value:4.53E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.06|P-value:8.97E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.09|P-value:1.54E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.90|P-value:3.43E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.30|P-value:1.29E-17 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.83|P-value:4.19E-7 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.07|P-value:8.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.69|P-value:8.23E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.30|P-value:3.76E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.68|P-value:8.83E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.68|P-value:8.74E-5 ID:SGTC_1725|Compound:st036284|FD-Score:6.64|P-value:6.33E-12 ID:SGTC_1769|Compound:st044406|FD-Score:4.38|P-value:3.92E-6 ID:SGTC_1862|Compound:st057513|FD-Score:3.08|P-value:8.48E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.06|P-value:1.75E-5 ID:SGTC_2197|Compound:6588183|FD-Score:4.71|P-value:7.90E-7 ID:SGTC_2278|Compound:7948257|FD-Score:4.66|P-value:9.91E-7 ID:SGTC_2375|Compound:9072683|FD-Score:5.11|P-value:9.53E-8 ID:SGTC_2403|Compound:6032726|FD-Score:8.59|P-value:9.84E-19 ID:SGTC_2444|Compound:5485484|FD-Score:3.92|P-value:3.16E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.75|P-value:6.49E-7 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.10|P-value:8.09E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.42|P-value:2.53E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.62|P-value:1.16E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.48|P-value:1.93E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.06|P-value:9.16E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.75|P-value:6.67E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.41|P-value:2.56E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.34|P-value:4.82E-6 ID:SGTC_2977|Compound:9011197|FD-Score:3.13|P-value:7.15E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.49|P-value:2.36E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.34|P-value:3.26E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.46|P-value:2.06E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.10|P-value:7.92E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.11|P-value:9.44E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:8.07|P-value:9.65E-17 ID:SGTC_369|Compound:0957-0393|FD-Score:3.12|P-value:7.21E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.37|P-value:2.99E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.11|P-value:7.66E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.91|P-value:3.30E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.21|P-value:8.94E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:4.23|P-value:7.95E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.84|P-value:4.53E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.06|P-value:8.97E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.09|P-value:1.54E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.90|P-value:3.43E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:8.30|P-value:1.29E-17 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.83|P-value:4.19E-7 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.07|P-value:8.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.69|P-value:8.23E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.30|P-value:3.76E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.68|P-value:8.83E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.68|P-value:8.74E-5 ID:SGTC_1725|Compound:st036284|FD-Score:6.64|P-value:6.33E-12 ID:SGTC_1769|Compound:st044406|FD-Score:4.38|P-value:3.92E-6 ID:SGTC_1862|Compound:st057513|FD-Score:3.08|P-value:8.48E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.06|P-value:1.75E-5 ID:SGTC_2197|Compound:6588183|FD-Score:4.71|P-value:7.90E-7 ID:SGTC_2278|Compound:7948257|FD-Score:4.66|P-value:9.91E-7 ID:SGTC_2375|Compound:9072683|FD-Score:5.11|P-value:9.53E-8 ID:SGTC_2403|Compound:6032726|FD-Score:8.59|P-value:9.84E-19 ID:SGTC_2444|Compound:5485484|FD-Score:3.92|P-value:3.16E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.75|P-value:6.49E-7 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.10|P-value:8.09E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.42|P-value:2.53E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.62|P-value:1.16E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.48|P-value:1.93E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.06|P-value:9.16E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.75|P-value:6.67E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.41|P-value:2.56E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.34|P-value:4.82E-6 ID:SGTC_2977|Compound:9011197|FD-Score:3.13|P-value:7.15E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.49|P-value:2.36E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.34|P-value:3.26E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.46|P-value:2.06E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.10|P-value:7.92E-4

Top fitness defect scores for YMR144W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 8.59 181.2 µM 9.84E-19 2 4.25E-18
2 SGTC_1133 3473-0247 8.30 50.0 µM 1.29E-17 RSC complex & mRNA processing 2 5.06E-17
3 SGTC_73 0327-0325 8.07 16.2 µM 9.65E-17 DNA damage response 6 3.52E-16
4 SGTC_1725 st036284 6.64 20.6 µM 6.33E-12 5 1.53E-11
5 SGTC_6 0844-0013 5.11 19.8 µM 9.44E-8 34 1.61E-7
6 SGTC_2375 9072683 5.11 200.0 µM 9.53E-8 mitochondrial processes 7 1.63E-7
7 SGTC_1179 1021-1431 4.83 9.3 µM 4.19E-7 21 6.78E-7
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.75 3.7 µM 6.49E-7 37 1.03E-6
9 SGTC_2197 6588183 4.71 93.1 µM 7.90E-7 15 1.25E-6
10 SGTC_2278 7948257 4.66 134.3 µM 9.91E-7 12 1.55E-6
11 SGTC_2978 9011784 4.49 43.0 µM 2.36E-6 17 3.59E-6
12 SGTC_1769 st044406 4.38 64.4 µM 3.92E-6 5 5.85E-6
13 SGTC_2967 9089538 4.34 49.9 µM 4.82E-6 24 7.15E-6
14 SGTC_572 0960-0087 4.23 17.7 µM 7.95E-6 22 1.16E-5
15 SGTC_545 4218-0007 4.21 221.0 µM 8.94E-6 20 1.30E-5
16 SGTC_974 1326-0144 4.09 138.0 µM 1.54E-5 ERG2 38 2.18E-5
17 SGTC_2111 5486399 4.06 200.0 µM 1.75E-5 42 2.47E-5
18 SGTC_2444 5485484 3.92 36.4 µM 3.16E-5 38 4.37E-5
19 SGTC_518 1021-0119 3.91 62.6 µM 3.30E-5 ERG2 37 4.56E-5
20 SGTC_986 1493-0483 3.90 84.0 µM 3.43E-5 11 4.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.52E-16 YMR032W HOF1 hom Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
0.129 5.63E-14 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.129 7.42E-14 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.127 1.32E-13 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.116 1.53E-11 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.115 2.44E-11 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.114 3.57E-11 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.113 5.61E-11 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.111 1.11E-10 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.109 2.62E-10 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.109 2.88E-10 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.108 3.20E-10 YOR022C_p YOR022C_p hom Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.105 8.98E-10 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.103 1.83E-9 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.102 3.55E-9 YLR250W SSP120 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern