YMR145C / NDE1

Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR145C / NDE1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.79|P-value:4.56E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:3.04|P-value:9.39E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.36|P-value:2.97E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.16|P-value:6.10E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.23|P-value:4.71E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.59|P-value:1.05E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.78|P-value:5.40E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.47|P-value:1.87E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.30|P-value:3.60E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.30|P-value:3.19E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.69|P-value:7.81E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.78|P-value:4.82E-7 ID:SGTC_1814|Compound:st052110|FD-Score:3.07|P-value:8.29E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.61|P-value:9.74E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.35|P-value:2.69E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.02|P-value:1.90E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.22|P-value:7.74E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-6.04|P-value:2.33E-10 ID:SGTC_2335|Compound:9018011|FD-Score:-3.50|P-value:1.47E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.56|P-value:1.32E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.22|P-value:4.24E-8 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.45|P-value:1.83E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.43|P-value:2.24E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.10|P-value:6.68E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.45|P-value:2.53E-6 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.32|P-value:4.69E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.05|P-value:8.16E-4 ID:SGTC_2744|Compound:captopril|FD-Score:-3.68|P-value:7.18E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.54|P-value:1.43E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.86|P-value:3.31E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.46|P-value:2.08E-6 ID:SGTC_3108|Compound:9121785|FD-Score:3.66|P-value:8.77E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.39|P-value:2.63E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.33|P-value:2.90E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.13|P-value:6.92E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.25|P-value:3.87E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.05|P-value:1.47E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.12|P-value:6.29E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.48|P-value:1.86E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.79|P-value:4.56E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:3.04|P-value:9.39E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.36|P-value:2.97E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.16|P-value:6.10E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.23|P-value:4.71E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.59|P-value:1.05E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.78|P-value:5.40E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.47|P-value:1.87E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.30|P-value:3.60E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.30|P-value:3.19E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.69|P-value:7.81E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.78|P-value:4.82E-7 ID:SGTC_1814|Compound:st052110|FD-Score:3.07|P-value:8.29E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.61|P-value:9.74E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.35|P-value:2.69E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.02|P-value:1.90E-5 ID:SGTC_2113|Compound:5491891|FD-Score:4.22|P-value:7.74E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-6.04|P-value:2.33E-10 ID:SGTC_2335|Compound:9018011|FD-Score:-3.50|P-value:1.47E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.56|P-value:1.32E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.22|P-value:4.24E-8 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.45|P-value:1.83E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.43|P-value:2.24E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.10|P-value:6.68E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.45|P-value:2.53E-6 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.32|P-value:4.69E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.05|P-value:8.16E-4 ID:SGTC_2744|Compound:captopril|FD-Score:-3.68|P-value:7.18E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.54|P-value:1.43E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.86|P-value:3.31E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.46|P-value:2.08E-6 ID:SGTC_3108|Compound:9121785|FD-Score:3.66|P-value:8.77E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.39|P-value:2.63E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.33|P-value:2.90E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.13|P-value:6.92E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.25|P-value:3.87E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.05|P-value:1.47E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.12|P-value:6.29E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.48|P-value:1.86E-4

Top fitness defect scores for YMR145C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.22 3.7 µM 4.24E-8 25 8.74E-8
2 SGTC_6 0844-0013 4.79 19.8 µM 4.56E-7 47 8.35E-7
3 SGTC_1630 st005209 4.78 31.3 µM 4.82E-7 11 8.80E-7
4 SGTC_2684 capsaicin 4.45 100.0 µM 2.53E-6 14 4.25E-6
5 SGTC_2723 salbutamol 4.32 83.6 µM 4.69E-6 6 7.65E-6
6 SGTC_2113 5491891 4.22 107.0 µM 7.74E-6 TSC3-RPN4 14 1.23E-5
7 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.02 70.1 µM 1.90E-5 23 2.89E-5
8 SGTC_857 0438-0306 3.78 1.4 µM 5.40E-5 copper-dependent oxidative stress 15 7.82E-5
9 SGTC_1546 5-methoxyflavanone 3.69 78.7 µM 7.81E-5 14 1.11E-4
10 SGTC_3108 9121785 3.66 49.5 µM 8.77E-5 21 1.24E-4
11 SGTC_2419 paclitaxel 3.56 166.5 µM 1.32E-4 61 1.83E-4
12 SGTC_2813 7971799 3.54 71.4 µM 1.43E-4 29 1.97E-4
13 SGTC_3298 9116858 3.48 71.4 µM 1.86E-4 23 2.54E-4
14 SGTC_1352 1496-0991 3.47 99.0 µM 1.87E-4 tubulin folding & SWR complex 42 2.56E-4
15 SGTC_2598 perillyl alcohol 3.43 100.0 µM 2.24E-4 56 3.03E-4
16 SGTC_3286 9117135 3.40 37.2 µM 2.53E-4 36 3.40E-4
17 SGTC_3109 9122853 3.39 49.5 µM 2.63E-4 21 3.54E-4
18 SGTC_160 3453-0671 3.36 289.7 µM 2.97E-4 60 3.97E-4
19 SGTC_3158 9100007 3.35 49.5 µM 3.02E-4 37 4.03E-4
20 SGTC_1449 4112-4002 3.30 201.0 µM 3.60E-4 RPP1 & pyrimidine depletion 29 4.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 9.53E-34 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.176 9.78E-25 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.165 5.53E-22 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.144 5.26E-17 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.143 1.03E-16 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.139 5.92E-16 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.134 7.17E-15 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.132 1.63E-14 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.128 9.25E-14 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.122 1.52E-12 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.121 1.83E-12 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.121 2.19E-12 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.120 2.83E-12 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.120 2.88E-12 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.119 5.02E-12 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm