HIPHOP chemogenomics database

YMR147W_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR147W / YMR147W

Click on Significant Values for Screen Details

Top fitness defect scores for YMR147W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1179	1021-1431	9.50	9.3 µM	1.74E-26		2	1.04E-21
2	SGTC_67	0335-0847	4.83	266.0 µM	3.49E-8	ubiquinone biosynthesis & proteasome	88	6.66E-7
3	SGTC_1177	0983-0204	4.79	23.6 µM	4.57E-8		6	8.29E-7
4	SGTC_2610	ononetin	4.72	44.2 µM	6.99E-8		20	1.17E-6
5	SGTC_2616	abietic acid	4.69	100.0 µM	8.31E-8		21	1.35E-6
6	SGTC_2611	pyromycin	4.51	23.9 µM	2.43E-7		12	3.22E-6
7	SGTC_2620	irigenin	4.46	100.0 µM	3.34E-7		19	4.17E-6
8	SGTC_2816	7982706	4.39	58.4 µM	4.86E-7	azole & statin	40	5.65E-6
9	SGTC_968	1309-0633	4.02	340.0 µM	3.58E-6		11	2.86E-5
10	SGTC_2621	lithochol-11-enic acid	3.70	100.0 µM	1.80E-5		33	1.06E-4
11	SGTC_381	3461-2219	3.39	42.7 µM	7.71E-5	copper-dependent oxidative stress	35	3.49E-4
12	SGTC_378	3970-0959	3.32	8.3 µM	1.05E-4		33	4.48E-4
13	SGTC_1967	st070177	3.26	51.4 µM	1.35E-4		39	5.49E-4
14	SGTC_1219	1469-0211	3.24	33.1 µM	1.48E-4		37	5.94E-4
15	SGTC_1172	0370-0043	3.02	85.0 µM	3.66E-4		59	0.00124
16	SGTC_1842	st055362	3.00	61.2 µM	4.05E-4		55	0.00135
17	SGTC_2456	5770359	2.92	74.5 µM	5.52E-4		54	0.00174
18	SGTC_2989	9073649	2.88	71.4 µM	6.53E-4		106	0.00199
19	SGTC_2935	9038016	2.85	30.0 µM	7.24E-4		75	0.00217
20	SGTC_133	0724-0033	2.78	378.9 µM	9.38E-4		75	0.00268

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.250	8.13E-49	YEL049W	PAU2	hom	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.245	6.34E-47	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.244	1.11E-46	YEL004W	YEA4	hom	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.243	2.52E-46	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.233	1.81E-42	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.224	1.65E-39	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.216	9.16E-37	YPR010C	RPA135	het	RNA polymerase I second largest subunit A135
0.215	2.98E-36	YKL220C	FRE2	hom	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.214	5.06E-36	YCR102W-A_d	YCR102W-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.214	5.42E-36	YGL146C_p	RRT6_p	hom	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.209	2.05E-34	YER071C_p	TDA2_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.209	2.50E-34	YMR210W	YMR210W	hom	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.206	1.81E-33	YBR118W	TEF2	hom	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.206	2.12E-33	YMR139W	RIM11	hom	Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.205	2.48E-33	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data