YMR148W / OSW5

Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR148W / OSW5

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:-3.05|P-value:1.11E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.00|P-value:1.40E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:2.98|P-value:1.41E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.27|P-value:6.92E-11 ID:SGTC_923|Compound:1900-2434|FD-Score:2.83|P-value:2.81E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.73|P-value:2.69E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.15|P-value:6.09E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.60|P-value:5.79E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-2.72|P-value:4.91E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.67|P-value:6.06E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.07|P-value:9.17E-5 ID:SGTC_1673|Compound:st016611|FD-Score:2.80|P-value:3.26E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.03|P-value:1.11E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.96|P-value:1.53E-4 ID:SGTC_2000|Compound:st075254|FD-Score:2.66|P-value:5.93E-4 ID:SGTC_2046|Compound:4110841|FD-Score:2.70|P-value:4.99E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.76|P-value:2.36E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.02|P-value:1.17E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.22|P-value:4.30E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.09|P-value:3.10E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.56|P-value:9.71E-4 ID:SGTC_2438|Compound:5259590|FD-Score:6.07|P-value:7.36E-14 ID:SGTC_2439|Compound:5492030|FD-Score:4.05|P-value:4.17E-7 ID:SGTC_2442|Compound:5158906|FD-Score:2.97|P-value:1.49E-4 ID:SGTC_2474|Compound:5321570|FD-Score:2.56|P-value:8.78E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.69|P-value:5.79E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.16|P-value:5.76E-5 ID:SGTC_2794|Compound:7785382|FD-Score:2.74|P-value:4.18E-4 ID:SGTC_2851|Compound:9015922|FD-Score:2.80|P-value:3.13E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.18|P-value:5.98E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.32|P-value:2.97E-5 ID:SGTC_3303|Compound:9125618|FD-Score:2.82|P-value:2.95E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.05|P-value:1.11E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.00|P-value:1.40E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:2.98|P-value:1.41E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.27|P-value:6.92E-11 ID:SGTC_923|Compound:1900-2434|FD-Score:2.83|P-value:2.81E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.73|P-value:2.69E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.15|P-value:6.09E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.60|P-value:5.79E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-2.72|P-value:4.91E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.67|P-value:6.06E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.07|P-value:9.17E-5 ID:SGTC_1673|Compound:st016611|FD-Score:2.80|P-value:3.26E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.03|P-value:1.11E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.96|P-value:1.53E-4 ID:SGTC_2000|Compound:st075254|FD-Score:2.66|P-value:5.93E-4 ID:SGTC_2046|Compound:4110841|FD-Score:2.70|P-value:4.99E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.76|P-value:2.36E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.02|P-value:1.17E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.22|P-value:4.30E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.09|P-value:3.10E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.56|P-value:9.71E-4 ID:SGTC_2438|Compound:5259590|FD-Score:6.07|P-value:7.36E-14 ID:SGTC_2439|Compound:5492030|FD-Score:4.05|P-value:4.17E-7 ID:SGTC_2442|Compound:5158906|FD-Score:2.97|P-value:1.49E-4 ID:SGTC_2474|Compound:5321570|FD-Score:2.56|P-value:8.78E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.69|P-value:5.79E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.16|P-value:5.76E-5 ID:SGTC_2794|Compound:7785382|FD-Score:2.74|P-value:4.18E-4 ID:SGTC_2851|Compound:9015922|FD-Score:2.80|P-value:3.13E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.18|P-value:5.98E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.32|P-value:2.97E-5 ID:SGTC_3303|Compound:9125618|FD-Score:2.82|P-value:2.95E-4

Top fitness defect scores for YMR148W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2438 5259590 6.07 200.0 µM 7.36E-14 4 6.28E-10
2 SGTC_921 1561-0023 5.27 372.0 µM 6.92E-11 3 6.72E-8
3 SGTC_2402 5553605 4.09 200.0 µM 3.10E-7 21 2.13E-5
4 SGTC_2439 5492030 4.05 7.2 µM 4.17E-7 12 2.61E-5
5 SGTC_2167 5876490 3.76 200.0 µM 2.36E-6 38 8.58E-5
6 SGTC_930 2810-3379 3.73 265.0 µM 2.69E-6 14 9.41E-5
7 SGTC_1395 3486-0190 3.60 4.3 µM 5.79E-6 23 1.59E-4
8 SGTC_2309 7664088 3.22 163.9 µM 4.30E-5 83 6.36E-4
9 SGTC_2605 digitonin 3.16 300.0 nM 5.76E-5 67 7.78E-4
10 SGTC_1360 1598-0022 3.15 39.8 µM 6.09E-5 ERG2 75 8.09E-4
11 SGTC_1475 4092-1048 3.07 11.7 µM 9.17E-5 plasma membrane duress 87 0.00107
12 SGTC_1677 st019204 3.03 53.9 µM 1.11E-4 64 0.00122
13 SGTC_2255 7941087 3.02 197.4 µM 1.17E-4 74 0.00127
14 SGTC_538 2922-0838 2.98 53.3 µM 1.41E-4 Golgi 85 0.00145
15 SGTC_2442 5158906 2.97 48.5 µM 1.49E-4 64 0.00151
16 SGTC_1889 st059080 2.96 5.2 µM 1.53E-4 62 0.00153
17 SGTC_923 1900-2434 2.83 73.3 µM 2.81E-4 RNA processing & uracil transport 90 0.00234
18 SGTC_3303 9125618 2.82 40.6 µM 2.95E-4 132 0.00241
19 SGTC_2851 9015922 2.80 71.4 µM 3.13E-4 107 0.00252
20 SGTC_1673 st016611 2.80 27.3 µM 3.26E-4 118 0.00259

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.64E-18 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.127 1.69E-13 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.122 1.15E-12 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.121 2.22E-12 YCR005C CIT2 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.120 2.52E-12 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.111 1.17E-10 YGR248W SOL4 hom 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
0.111 1.30E-10 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.109 2.32E-10 YIL165C_p YIL165C_p hom Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene
0.109 2.48E-10 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.106 8.20E-10 YGR286C BIO2 hom Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.103 2.50E-9 YOR139C_d YOR139C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W
0.102 2.72E-9 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.096 2.77E-8 YGL115W SNF4 hom Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress
0.092 8.57E-8 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.092 9.71E-8 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress