YMR149W / SWP1

Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR149W / SWP1

Click on Significant Values for Screen Details ID:SGTC_170|Compound:4197-0004|FD-Score:2.97|P-value:3.33E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-4.74|P-value:2.91E-8 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:2.71|P-value:9.53E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.93|P-value:4.01E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.92|P-value:4.08E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:2.70|P-value:9.91E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-2.82|P-value:6.20E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:2.70|P-value:9.89E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.51|P-value:2.88E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.51|P-value:2.89E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.89|P-value:4.31E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:-2.78|P-value:7.36E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-2.92|P-value:4.12E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.19|P-value:1.28E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:2.93|P-value:3.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.47|P-value:1.58E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.27|P-value:9.17E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.10|P-value:1.91E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.99|P-value:3.10E-4 ID:SGTC_1855|Compound:st056195|FD-Score:6.98|P-value:6.56E-16 ID:SGTC_1859|Compound:st055998|FD-Score:5.11|P-value:2.45E-9 ID:SGTC_1920|Compound:st075728|FD-Score:3.45|P-value:3.87E-5 ID:SGTC_1924|Compound:st058459|FD-Score:4.34|P-value:3.43E-7 ID:SGTC_1932|Compound:st074806|FD-Score:-2.79|P-value:7.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-5.21|P-value:1.22E-9 ID:SGTC_1934|Compound:st074720|FD-Score:-4.55|P-value:9.48E-8 ID:SGTC_1956|Compound:st077085|FD-Score:3.27|P-value:9.27E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.08|P-value:2.06E-4 ID:SGTC_2284|Compound:7945075|FD-Score:2.95|P-value:3.62E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.76|P-value:7.74E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.36|P-value:6.11E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.13|P-value:1.14E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.21|P-value:1.20E-4 ID:SGTC_2401|Compound:5128683|FD-Score:5.90|P-value:7.35E-12 ID:SGTC_2403|Compound:6032726|FD-Score:-6.14|P-value:1.10E-12 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.72|P-value:9.30E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.85|P-value:5.51E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.29|P-value:8.30E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.41|P-value:4.77E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-2.83|P-value:6.09E-4 ID:SGTC_2851|Compound:9015922|FD-Score:2.88|P-value:4.97E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.81|P-value:6.43E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-2.82|P-value:6.30E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.77|P-value:7.62E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.08|P-value:3.13E-9 ID:SGTC_2987|Compound:9018338|FD-Score:-3.75|P-value:8.84E-6 ID:SGTC_3073|Compound:9114972|FD-Score:3.30|P-value:7.79E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.22|P-value:1.13E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.64|P-value:1.51E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.75|P-value:8.86E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.19|P-value:8.00E-7 ID:SGTC_3209|Compound:9113616|FD-Score:3.77|P-value:7.80E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:2.97|P-value:3.33E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-4.74|P-value:2.91E-8 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:2.71|P-value:9.53E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.93|P-value:4.01E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.92|P-value:4.08E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:2.70|P-value:9.91E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-2.82|P-value:6.20E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:2.70|P-value:9.89E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.51|P-value:2.88E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.51|P-value:2.89E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.89|P-value:4.31E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:-2.78|P-value:7.36E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-2.92|P-value:4.12E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.19|P-value:1.28E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:2.93|P-value:3.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.47|P-value:1.58E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.27|P-value:9.17E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.10|P-value:1.91E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.99|P-value:3.10E-4 ID:SGTC_1855|Compound:st056195|FD-Score:6.98|P-value:6.56E-16 ID:SGTC_1859|Compound:st055998|FD-Score:5.11|P-value:2.45E-9 ID:SGTC_1920|Compound:st075728|FD-Score:3.45|P-value:3.87E-5 ID:SGTC_1924|Compound:st058459|FD-Score:4.34|P-value:3.43E-7 ID:SGTC_1932|Compound:st074806|FD-Score:-2.79|P-value:7.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-5.21|P-value:1.22E-9 ID:SGTC_1934|Compound:st074720|FD-Score:-4.55|P-value:9.48E-8 ID:SGTC_1956|Compound:st077085|FD-Score:3.27|P-value:9.27E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.08|P-value:2.06E-4 ID:SGTC_2284|Compound:7945075|FD-Score:2.95|P-value:3.62E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.76|P-value:7.74E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.36|P-value:6.11E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.13|P-value:1.14E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.21|P-value:1.20E-4 ID:SGTC_2401|Compound:5128683|FD-Score:5.90|P-value:7.35E-12 ID:SGTC_2403|Compound:6032726|FD-Score:-6.14|P-value:1.10E-12 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.72|P-value:9.30E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.85|P-value:5.51E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.29|P-value:8.30E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.41|P-value:4.77E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-2.83|P-value:6.09E-4 ID:SGTC_2851|Compound:9015922|FD-Score:2.88|P-value:4.97E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.81|P-value:6.43E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-2.82|P-value:6.30E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.77|P-value:7.62E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.08|P-value:3.13E-9 ID:SGTC_2987|Compound:9018338|FD-Score:-3.75|P-value:8.84E-6 ID:SGTC_3073|Compound:9114972|FD-Score:3.30|P-value:7.79E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.22|P-value:1.13E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.64|P-value:1.51E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.75|P-value:8.86E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.19|P-value:8.00E-7 ID:SGTC_3209|Compound:9113616|FD-Score:3.77|P-value:7.80E-6

Top fitness defect scores for YMR149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1855 st056195 6.98 39.6 µM 6.56E-16 60S ribosome export 2 1.44E-12 1.67
2 SGTC_2401 5128683 5.90 200.0 µM 7.35E-12 2 1.84E-9 0.20
3 SGTC_1859 st055998 5.11 20.0 µM 2.45E-9 1 1.60E-7 0.60
4 SGTC_2973 9094665 5.08 18.0 µM 3.13E-9 NEO1 11 1.94E-7 0.49
5 SGTC_1924 st058459 4.34 75.1 µM 3.43E-7 3 7.21E-6 0.06
6 SGTC_3208 9114115 4.19 49.5 µM 8.00E-7 8 1.39E-5 0.13
7 SGTC_2399 5884133 4.13 200.0 µM 1.14E-6 cell wall signaling 18 1.83E-5 0.15
8 SGTC_783 0848-0141 3.89 92.7 µM 4.31E-6 RSC & ERG11 15 5.08E-5 0.01
9 SGTC_3209 9113616 3.77 49.5 µM 7.80E-6 6 8.05E-5 0.12
10 SGTC_3200 9114385 3.64 49.5 µM 1.51E-5 24 1.34E-4 0.15
11 SGTC_621 3584-0052 3.51 32.1 µM 2.88E-5 6 2.21E-4 0.23
12 SGTC_1920 st075728 3.45 45.7 µM 3.87E-5 8 2.78E-4 0.03
13 SGTC_2757 clomiphene 3.41 4.2 µM 4.77E-5 fatty acid desaturase (OLE1) 24 3.27E-4 0.01
14 SGTC_2376 9072922 3.36 81.3 µM 6.11E-5 8 3.96E-4 0.03
15 SGTC_3073 9114972 3.30 49.5 µM 7.79E-5 60S ribosome export 10 4.78E-4 0.02
16 SGTC_2752 diclazuril 3.29 33.1 µM 8.30E-5 17 5.02E-4 0.15
17 SGTC_1118 chelidonine 3.27 707.5 nM 9.17E-5 8 5.43E-4 0.11
18 SGTC_1956 st077085 3.27 54.0 µM 9.27E-5 6 5.47E-4 0.01
19 SGTC_920 mycophenolic acid 3.19 780.4 nM 1.28E-4 11 7.02E-4 0.03
20 SGTC_1279 0874-0590 3.10 65.2 µM 1.91E-4 5 9.57E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.20E-26 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.151 1.13E-18 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.140 4.82E-16 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.133 8.78E-15 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.129 6.42E-14 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.128 9.58E-14 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.128 1.18E-13 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.126 2.71E-13 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.125 3.75E-13 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.122 1.11E-12 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.122 1.60E-12 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.121 2.01E-12 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.118 6.97E-12 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.118 7.85E-12 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.117 8.87E-12 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network