YMR152W / YIM1

Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR152W / YIM1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-4.13|P-value:4.03E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.47|P-value:6.41E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:7.32|P-value:5.93E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:10.50|P-value:1.22E-24 ID:SGTC_61|Compound:0978-8327|FD-Score:3.41|P-value:4.32E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.73|P-value:1.33E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.45|P-value:1.18E-16 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.07|P-value:3.51E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.39|P-value:4.53E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.01|P-value:5.37E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:3.83|P-value:9.07E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.36|P-value:6.90E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.25|P-value:7.27E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.84|P-value:8.68E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.87|P-value:1.05E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.36|P-value:1.07E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.58|P-value:4.03E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.78|P-value:1.12E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.31|P-value:6.09E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.23|P-value:1.80E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:4.64|P-value:3.10E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.89|P-value:1.44E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.27|P-value:6.80E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.32|P-value:7.76E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.24|P-value:7.53E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.65|P-value:2.49E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.98|P-value:5.08E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.18|P-value:9.33E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.85|P-value:8.60E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.22|P-value:8.17E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.17|P-value:9.42E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.30|P-value:1.35E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.30|P-value:6.14E-4 ID:SGTC_1709|Compound:st033179|FD-Score:9.43|P-value:2.83E-20 ID:SGTC_1712|Compound:st032288|FD-Score:4.54|P-value:4.70E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.30|P-value:8.38E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.72|P-value:1.39E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.62|P-value:1.99E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.16|P-value:9.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.09|P-value:3.23E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.27|P-value:9.23E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.21|P-value:8.36E-4 ID:SGTC_2477|Compound:5967686|FD-Score:4.32|P-value:1.24E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.57|P-value:2.44E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.41|P-value:4.24E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.68|P-value:2.57E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:6.04|P-value:2.06E-9 ID:SGTC_2709|Compound:st078560|FD-Score:4.35|P-value:1.11E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.19|P-value:8.81E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.53|P-value:2.76E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.26|P-value:7.16E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.36|P-value:6.86E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.68|P-value:2.51E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.58|P-value:3.91E-6 ID:SGTC_3347|Compound:9188721|FD-Score:-3.38|P-value:6.51E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.13|P-value:4.03E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.47|P-value:6.41E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:7.32|P-value:5.93E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:10.50|P-value:1.22E-24 ID:SGTC_61|Compound:0978-8327|FD-Score:3.41|P-value:4.32E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.73|P-value:1.33E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.45|P-value:1.18E-16 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.07|P-value:3.51E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.39|P-value:4.53E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.01|P-value:5.37E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:3.83|P-value:9.07E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.36|P-value:6.90E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.25|P-value:7.27E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.84|P-value:8.68E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.87|P-value:1.05E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.36|P-value:1.07E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.58|P-value:4.03E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.78|P-value:1.12E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.31|P-value:6.09E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.23|P-value:1.80E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:4.64|P-value:3.10E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.89|P-value:1.44E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.27|P-value:6.80E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.32|P-value:7.76E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.24|P-value:7.53E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.65|P-value:2.49E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.98|P-value:5.08E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.18|P-value:9.33E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.85|P-value:8.60E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.22|P-value:8.17E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.17|P-value:9.42E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.30|P-value:1.35E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.30|P-value:6.14E-4 ID:SGTC_1709|Compound:st033179|FD-Score:9.43|P-value:2.83E-20 ID:SGTC_1712|Compound:st032288|FD-Score:4.54|P-value:4.70E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.30|P-value:8.38E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.72|P-value:1.39E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.62|P-value:1.99E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.16|P-value:9.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.09|P-value:3.23E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.27|P-value:9.23E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.21|P-value:8.36E-4 ID:SGTC_2477|Compound:5967686|FD-Score:4.32|P-value:1.24E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.57|P-value:2.44E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.41|P-value:4.24E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.68|P-value:2.57E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:6.04|P-value:2.06E-9 ID:SGTC_2709|Compound:st078560|FD-Score:4.35|P-value:1.11E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.19|P-value:8.81E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.53|P-value:2.76E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.26|P-value:7.16E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.36|P-value:6.86E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.68|P-value:2.51E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.58|P-value:3.91E-6 ID:SGTC_3347|Compound:9188721|FD-Score:-3.38|P-value:6.51E-4

Top fitness defect scores for YMR152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 10.50 9.0 µM 1.22E-24 cell wall 71 4.41E-26
2 SGTC_1709 st033179 9.43 39.1 µM 2.83E-20 1 2.01E-21
3 SGTC_138 0850-0259 8.45 40.9 µM 1.18E-16 cell wall 58 1.45E-17
4 SGTC_44 0929-0055 7.32 61.2 µM 5.93E-13 5 1.28E-13
5 SGTC_2619 obliquin 6.04 87.9 µM 2.06E-9 cell wall 73 7.52E-10
6 SGTC_514 4466-0038 5.01 2.6 nM 5.37E-7 cell wall 107 2.77E-7
7 SGTC_676 falcarinol 4.87 140.0 µM 1.05E-6 36 5.62E-7
8 SGTC_3311 9131146 4.68 2.9 µM 2.51E-6 cell wall 93 1.42E-6
9 SGTC_2610 ononetin 4.68 44.2 µM 2.57E-6 21 1.46E-6
10 SGTC_954 1189-0853 4.64 2.9 µM 3.10E-6 endomembrane recycling 23 1.78E-6
11 SGTC_3321 9137793 4.58 26.8 µM 3.91E-6 cell wall 60 2.27E-6
12 SGTC_742 0kpi-0133 4.58 140.0 µM 4.03E-6 ERG2 11 2.35E-6
13 SGTC_1712 st032288 4.54 53.4 µM 4.70E-6 calcium & mitochondrial duress 141 2.76E-6
14 SGTC_39 0986-0283 4.47 58.4 µM 6.41E-6 calcium & mitochondrial duress 21 3.84E-6
15 SGTC_740 k014-0057 4.36 261.0 µM 1.07E-5 17 6.58E-6
16 SGTC_2709 st078560 4.35 56.0 µM 1.11E-5 5 6.90E-6
17 SGTC_2477 5967686 4.32 25.2 µM 1.24E-5 19 7.73E-6
18 SGTC_1636 st007707 4.30 68.9 µM 1.35E-5 41 8.43E-6
19 SGTC_951 1171-0579 4.23 82.7 µM 1.80E-5 cell wall 66 1.15E-5
20 SGTC_2248 tofa 4.09 1.1 µM 3.23E-5 sphingolipid biosynthesis & PDR1 37 2.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.358 4.41E-102 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.340 1.27E-91 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.331 8.25E-87 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.327 1.11E-84 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.325 1.55E-83 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.320 9.12E-81 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.320 1.88E-80 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.315 2.18E-78 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.311 5.58E-76 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.310 1.54E-75 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.309 3.23E-75 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.309 5.06E-75 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.300 7.47E-71 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.300 1.12E-70 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.288 3.84E-65 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases