YMR154C / RIM13

Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR154C / RIM13

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.32|P-value:9.33E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.53|P-value:6.91E-11 ID:SGTC_63|Compound:0099-0242|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-5.83|P-value:4.84E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:3.65|P-value:1.76E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:6.23|P-value:4.98E-10 ID:SGTC_197|Compound:4544-0043|FD-Score:5.46|P-value:4.42E-8 ID:SGTC_206|Compound:4546-0025|FD-Score:4.19|P-value:2.04E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:5.34|P-value:8.37E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.52|P-value:2.83E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.03|P-value:4.00E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.53|P-value:7.42E-11 ID:SGTC_227|Compound:fluconazole|FD-Score:15.60|P-value:2.10E-53 ID:SGTC_252|Compound:miconazole|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.70|P-value:1.36E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:5.44|P-value:4.91E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:6.72|P-value:2.29E-11 ID:SGTC_299|Compound:1273-0059|FD-Score:3.60|P-value:2.11E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.14|P-value:9.82E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.30|P-value:6.20E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:6.24|P-value:4.79E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.72|P-value:1.37E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.05|P-value:3.65E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.65|P-value:2.63E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:4.08|P-value:3.21E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.28|P-value:1.37E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:14.90|P-value:5.57E-49 ID:SGTC_367|Compound:0335-0881|FD-Score:3.94|P-value:5.68E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.50|P-value:4.64E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.69|P-value:1.49E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.62|P-value:1.96E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.15|P-value:2.41E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.00|P-value:4.52E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:14.80|P-value:3.76E-48 ID:SGTC_526|Compound:4469-0568|FD-Score:8.47|P-value:5.04E-17 ID:SGTC_528|Compound:3492-0019|FD-Score:14.40|P-value:1.54E-45 ID:SGTC_555|Compound:4296-0685|FD-Score:3.38|P-value:4.66E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.79|P-value:1.08E-14 ID:SGTC_577|Compound:r071-0003|FD-Score:3.27|P-value:6.96E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:5.04|P-value:3.97E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:4.05|P-value:3.65E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.31|P-value:1.20E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:5.32|P-value:9.37E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:4.52|P-value:4.66E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:7.66|P-value:2.83E-14 ID:SGTC_804|Compound:1595-0054|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.12|P-value:2.62E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:10.70|P-value:3.22E-26 ID:SGTC_902|Compound:1120-0002|FD-Score:6.92|P-value:5.76E-12 ID:SGTC_922|Compound:1866-0035|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.61|P-value:2.00E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.35|P-value:1.02E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:8.70|P-value:7.34E-18 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.47|P-value:3.45E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.83|P-value:8.76E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.15|P-value:2.25E-7 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.16|P-value:2.13E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.38|P-value:1.72E-20 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.33|P-value:1.50E-16 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.72|P-value:1.36E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.37|P-value:4.77E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.70|P-value:1.48E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.71|P-value:1.99E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:15.20|P-value:1.55E-50 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.47|P-value:5.99E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:6.24|P-value:4.78E-10 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.59|P-value:2.19E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.44|P-value:4.84E-8 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.25|P-value:7.28E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-6.67|P-value:2.62E-11 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.83|P-value:8.71E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.74|P-value:9.34E-9 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.33|P-value:1.11E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:9.80|P-value:3.37E-22 ID:SGTC_1311|Compound:1190-0148|FD-Score:8.00|P-value:2.20E-15 ID:SGTC_1317|Compound:1273-0028|FD-Score:32.00|P-value:7.66E-217 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.11|P-value:1.04E-9 ID:SGTC_1712|Compound:st032288|FD-Score:4.34|P-value:1.06E-5 ID:SGTC_1741|Compound:st038134|FD-Score:4.06|P-value:3.47E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.44|P-value:6.93E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-4.11|P-value:2.62E-5 ID:SGTC_1754|Compound:st042065|FD-Score:5.04|P-value:4.00E-7 ID:SGTC_1760|Compound:st045453|FD-Score:7.91|P-value:4.48E-15 ID:SGTC_1788|Compound:fluconazole|FD-Score:17.90|P-value:3.70E-69 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_1797|Compound:st048695|FD-Score:5.40|P-value:6.03E-8 ID:SGTC_1800|Compound:st050079|FD-Score:7.89|P-value:5.18E-15 ID:SGTC_1801|Compound:st050089|FD-Score:6.75|P-value:1.78E-11 ID:SGTC_1803|Compound:st050068|FD-Score:8.58|P-value:1.90E-17 ID:SGTC_1818|Compound:st052136|FD-Score:3.75|P-value:1.21E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.30|P-value:6.13E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.87|P-value:7.56E-5 ID:SGTC_1831|Compound:st055328|FD-Score:6.05|P-value:1.52E-9 ID:SGTC_1834|Compound:st055981|FD-Score:-4.55|P-value:3.71E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.63|P-value:3.47E-11 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.40|P-value:8.21E-6 ID:SGTC_1884|Compound:5633444|FD-Score:9.16|P-value:1.29E-19 ID:SGTC_1893|Compound:st059353|FD-Score:3.20|P-value:8.62E-4 ID:SGTC_1925|Compound:st057770|FD-Score:4.30|P-value:1.27E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.47|P-value:3.66E-8 ID:SGTC_1933|Compound:st074711|FD-Score:8.36|P-value:1.18E-16 ID:SGTC_1941|Compound:st076221|FD-Score:4.10|P-value:2.99E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.18|P-value:9.19E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.23|P-value:7.76E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.17|P-value:2.17E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.82|P-value:9.23E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.17|P-value:2.22E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.32|P-value:5.79E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.94|P-value:5.67E-5 ID:SGTC_2201|Compound:6605497|FD-Score:3.37|P-value:4.84E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.16|P-value:2.27E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.84|P-value:1.07E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.55|P-value:2.39E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.50|P-value:3.49E-8 ID:SGTC_2488|Compound:5268135|FD-Score:-3.31|P-value:5.65E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.16|P-value:9.32E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-6.29|P-value:3.13E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.93|P-value:6.92E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.99|P-value:5.00E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:4.73|P-value:1.81E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.61|P-value:4.27E-14 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.09|P-value:3.08E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.23|P-value:1.53E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.74|P-value:6.28E-22 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.37|P-value:2.54E-13 ID:SGTC_2756|Compound:carbadox|FD-Score:5.22|P-value:1.57E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.50|P-value:5.22E-6 ID:SGTC_2816|Compound:7982706|FD-Score:4.12|P-value:2.74E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-4.45|P-value:5.98E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.42|P-value:3.76E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.45|P-value:6.48E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_2925|Compound:9010536|FD-Score:9.54|P-value:3.98E-21 ID:SGTC_2927|Compound:9011802|FD-Score:-3.25|P-value:6.95E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.62|P-value:1.76E-8 ID:SGTC_2930|Compound:9013230|FD-Score:5.89|P-value:3.92E-9 ID:SGTC_2943|Compound:9068529|FD-Score:-3.56|P-value:2.24E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.41|P-value:7.96E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.87|P-value:7.66E-5 ID:SGTC_2971|Compound:9092186|FD-Score:8.64|P-value:1.21E-17 ID:SGTC_2973|Compound:9094665|FD-Score:4.93|P-value:6.65E-7 ID:SGTC_2974|Compound:9094440|FD-Score:4.80|P-value:1.26E-6 ID:SGTC_3037|Compound:9091026|FD-Score:6.21|P-value:5.82E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.21|P-value:7.72E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.66|P-value:1.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:13.40|P-value:5.35E-40 ID:SGTC_3189|Compound:9110682|FD-Score:7.75|P-value:1.50E-14 ID:SGTC_3279|Compound:9140807|FD-Score:4.65|P-value:2.61E-6 ID:SGTC_3296|Compound:9122258|FD-Score:3.21|P-value:8.34E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.96|P-value:2.54E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:5.32|P-value:9.33E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.53|P-value:6.91E-11 ID:SGTC_63|Compound:0099-0242|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-5.83|P-value:4.84E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:3.65|P-value:1.76E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:6.23|P-value:4.98E-10 ID:SGTC_197|Compound:4544-0043|FD-Score:5.46|P-value:4.42E-8 ID:SGTC_206|Compound:4546-0025|FD-Score:4.19|P-value:2.04E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:5.34|P-value:8.37E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.52|P-value:2.83E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.03|P-value:4.00E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.53|P-value:7.42E-11 ID:SGTC_227|Compound:fluconazole|FD-Score:15.60|P-value:2.10E-53 ID:SGTC_252|Compound:miconazole|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.70|P-value:1.36E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:5.44|P-value:4.91E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:6.72|P-value:2.29E-11 ID:SGTC_299|Compound:1273-0059|FD-Score:3.60|P-value:2.11E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.14|P-value:9.82E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.30|P-value:6.20E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:6.24|P-value:4.79E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.72|P-value:1.37E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.05|P-value:3.65E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.65|P-value:2.63E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:4.08|P-value:3.21E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.28|P-value:1.37E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:14.90|P-value:5.57E-49 ID:SGTC_367|Compound:0335-0881|FD-Score:3.94|P-value:5.68E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.50|P-value:4.64E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.69|P-value:1.49E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.62|P-value:1.96E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.15|P-value:2.41E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.00|P-value:4.52E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:14.80|P-value:3.76E-48 ID:SGTC_526|Compound:4469-0568|FD-Score:8.47|P-value:5.04E-17 ID:SGTC_528|Compound:3492-0019|FD-Score:14.40|P-value:1.54E-45 ID:SGTC_555|Compound:4296-0685|FD-Score:3.38|P-value:4.66E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.79|P-value:1.08E-14 ID:SGTC_577|Compound:r071-0003|FD-Score:3.27|P-value:6.96E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:5.04|P-value:3.97E-7 ID:SGTC_658|Compound:3253-0951|FD-Score:4.05|P-value:3.65E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.31|P-value:1.20E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:5.32|P-value:9.37E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:4.52|P-value:4.66E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:7.66|P-value:2.83E-14 ID:SGTC_804|Compound:1595-0054|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.12|P-value:2.62E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:10.70|P-value:3.22E-26 ID:SGTC_902|Compound:1120-0002|FD-Score:6.92|P-value:5.76E-12 ID:SGTC_922|Compound:1866-0035|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.61|P-value:2.00E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.35|P-value:1.02E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:8.70|P-value:7.34E-18 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.47|P-value:3.45E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.83|P-value:8.76E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.15|P-value:2.25E-7 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.16|P-value:2.13E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.38|P-value:1.72E-20 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.33|P-value:1.50E-16 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.72|P-value:1.36E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.37|P-value:4.77E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.70|P-value:1.48E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.71|P-value:1.99E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:15.20|P-value:1.55E-50 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.47|P-value:5.99E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:6.24|P-value:4.78E-10 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.59|P-value:2.19E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.44|P-value:4.84E-8 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.25|P-value:7.28E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-6.67|P-value:2.62E-11 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.83|P-value:8.71E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.74|P-value:9.34E-9 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.33|P-value:1.11E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:9.80|P-value:3.37E-22 ID:SGTC_1311|Compound:1190-0148|FD-Score:8.00|P-value:2.20E-15 ID:SGTC_1317|Compound:1273-0028|FD-Score:32.00|P-value:7.66E-217 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.11|P-value:1.04E-9 ID:SGTC_1712|Compound:st032288|FD-Score:4.34|P-value:1.06E-5 ID:SGTC_1741|Compound:st038134|FD-Score:4.06|P-value:3.47E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.44|P-value:6.93E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-4.11|P-value:2.62E-5 ID:SGTC_1754|Compound:st042065|FD-Score:5.04|P-value:4.00E-7 ID:SGTC_1760|Compound:st045453|FD-Score:7.91|P-value:4.48E-15 ID:SGTC_1788|Compound:fluconazole|FD-Score:17.90|P-value:3.70E-69 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_1797|Compound:st048695|FD-Score:5.40|P-value:6.03E-8 ID:SGTC_1800|Compound:st050079|FD-Score:7.89|P-value:5.18E-15 ID:SGTC_1801|Compound:st050089|FD-Score:6.75|P-value:1.78E-11 ID:SGTC_1803|Compound:st050068|FD-Score:8.58|P-value:1.90E-17 ID:SGTC_1818|Compound:st052136|FD-Score:3.75|P-value:1.21E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.30|P-value:6.13E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.87|P-value:7.56E-5 ID:SGTC_1831|Compound:st055328|FD-Score:6.05|P-value:1.52E-9 ID:SGTC_1834|Compound:st055981|FD-Score:-4.55|P-value:3.71E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.63|P-value:3.47E-11 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.40|P-value:8.21E-6 ID:SGTC_1884|Compound:5633444|FD-Score:9.16|P-value:1.29E-19 ID:SGTC_1893|Compound:st059353|FD-Score:3.20|P-value:8.62E-4 ID:SGTC_1925|Compound:st057770|FD-Score:4.30|P-value:1.27E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.47|P-value:3.66E-8 ID:SGTC_1933|Compound:st074711|FD-Score:8.36|P-value:1.18E-16 ID:SGTC_1941|Compound:st076221|FD-Score:4.10|P-value:2.99E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.18|P-value:9.19E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.23|P-value:7.76E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.17|P-value:2.17E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.82|P-value:9.23E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.17|P-value:2.22E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.32|P-value:5.79E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.94|P-value:5.67E-5 ID:SGTC_2201|Compound:6605497|FD-Score:3.37|P-value:4.84E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.16|P-value:2.27E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.84|P-value:1.07E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.55|P-value:2.39E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.50|P-value:3.49E-8 ID:SGTC_2488|Compound:5268135|FD-Score:-3.31|P-value:5.65E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.16|P-value:9.32E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-6.29|P-value:3.13E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.93|P-value:6.92E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.99|P-value:5.00E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:4.73|P-value:1.81E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.61|P-value:4.27E-14 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.09|P-value:3.08E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.23|P-value:1.53E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.74|P-value:6.28E-22 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.37|P-value:2.54E-13 ID:SGTC_2756|Compound:carbadox|FD-Score:5.22|P-value:1.57E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.50|P-value:5.22E-6 ID:SGTC_2816|Compound:7982706|FD-Score:4.12|P-value:2.74E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-4.45|P-value:5.98E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.42|P-value:3.76E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.45|P-value:6.48E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_2925|Compound:9010536|FD-Score:9.54|P-value:3.98E-21 ID:SGTC_2927|Compound:9011802|FD-Score:-3.25|P-value:6.95E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.62|P-value:1.76E-8 ID:SGTC_2930|Compound:9013230|FD-Score:5.89|P-value:3.92E-9 ID:SGTC_2943|Compound:9068529|FD-Score:-3.56|P-value:2.24E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.41|P-value:7.96E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.87|P-value:7.66E-5 ID:SGTC_2971|Compound:9092186|FD-Score:8.64|P-value:1.21E-17 ID:SGTC_2973|Compound:9094665|FD-Score:4.93|P-value:6.65E-7 ID:SGTC_2974|Compound:9094440|FD-Score:4.80|P-value:1.26E-6 ID:SGTC_3037|Compound:9091026|FD-Score:6.21|P-value:5.82E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.21|P-value:7.72E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.66|P-value:1.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:13.40|P-value:5.35E-40 ID:SGTC_3189|Compound:9110682|FD-Score:7.75|P-value:1.50E-14 ID:SGTC_3279|Compound:9140807|FD-Score:4.65|P-value:2.61E-6 ID:SGTC_3296|Compound:9122258|FD-Score:3.21|P-value:8.34E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.96|P-value:2.54E-9

Top fitness defect scores for YMR154C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1317 1273-0028 32.00 910.0 nM 7.66E-217 azole & statin 1 6.22E-225
2 SGTC_1788 fluconazole 17.90 20.0 µM 3.70E-69 azole & statin 5 1.01E-71
3 SGTC_227 fluconazole 15.60 33.5 µM 2.10E-53 azole & statin 5 2.25E-55
4 SGTC_1191 1487-1166 15.20 10.6 µM 1.55E-50 azole & statin 1 2.12E-52
5 SGTC_363 0455-0021 14.90 3.1 µM 5.57E-49 azole & statin 2 8.72E-51
6 SGTC_525 k781-2675 14.80 26.7 µM 3.76E-48 redox potentiating 1 6.33E-50
7 SGTC_528 3492-0019 14.40 172.0 µM 1.54E-45 calcium & mitochondrial duress 19 3.26E-47
8 SGTC_3152 9099253 13.40 49.5 µM 5.35E-40 NEO1-PIK1 8 1.83E-41
9 SGTC_862 0452-0056 10.70 10.2 µM 3.22E-26 azole & statin 3 3.63E-27
10 SGTC_1310 1188-0297 9.80 994.0 nM 3.37E-22 azole & statin 1 5.38E-23
11 SGTC_2688 kanamycin b 9.74 96.7 µM 6.28E-22 calcium & mitochondrial duress 29 1.03E-22
12 SGTC_2925 9010536 9.54 32.5 µM 3.98E-21 azole & statin 5 6.97E-22
13 SGTC_1083 didemethylchlorpromazine sulfoxide 9.38 707.4 nM 1.72E-20 redox potentiating 8 3.19E-21
14 SGTC_1884 5633444 9.16 25.0 µM 1.29E-19 redox potentiating 15 2.59E-20
15 SGTC_978 1416-0512 8.70 87.4 µM 7.34E-18 redox potentiating 3 1.71E-18
16 SGTC_2971 9092186 8.64 9.9 µM 1.21E-17 ergosterol biosynthesis 2 2.86E-18
17 SGTC_1803 st050068 8.58 52.4 µM 1.90E-17 NEO1-PIK1 31 4.59E-18
18 SGTC_526 4469-0568 8.47 170.0 µM 5.04E-17 azole & statin 8 1.26E-17
19 SGTC_1933 st074711 8.36 15.9 µM 1.18E-16 3 3.06E-17
20 SGTC_1084 voriconazole 8.33 435.0 nM 1.50E-16 azole & statin 3 3.91E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.684 0 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.653 0 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.599 0 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.585 3.22E-306 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.580 1.67E-299 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.572 4.77E-289 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.462 6.87E-176 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.402 2.44E-130 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.395 4.77E-125 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.384 9.11E-118 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.346 9.02E-95 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.340 2.91E-91 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.335 1.15E-88 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.308 2.64E-74 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.293 2.81E-67 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum