YMR155W_p

Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR155W / YMR155W

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:-4.53|P-value:2.90E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.74|P-value:9.39E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.28|P-value:4.73E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.26|P-value:4.92E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.93|P-value:3.77E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.36|P-value:3.51E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.09|P-value:9.08E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.35|P-value:4.06E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.43|P-value:3.05E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.72|P-value:8.59E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.23|P-value:5.65E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.20|P-value:6.96E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.26|P-value:5.77E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.16|P-value:7.21E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.15|P-value:8.25E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.12|P-value:8.05E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.04|P-value:2.30E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.43|P-value:2.67E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.17|P-value:1.30E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.38|P-value:3.18E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.43|P-value:2.73E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.14|P-value:7.52E-4 ID:SGTC_1807|Compound:st050092|FD-Score:-3.44|P-value:2.93E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-3.97|P-value:3.69E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.18|P-value:1.24E-5 ID:SGTC_1825|Compound:st052143|FD-Score:3.41|P-value:2.88E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.61|P-value:1.36E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.59|P-value:1.66E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.40|P-value:2.96E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.47|P-value:2.32E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-4.26|P-value:1.03E-5 ID:SGTC_2426|Compound:5582046|FD-Score:7.88|P-value:1.09E-15 ID:SGTC_2429|Compound:5902844|FD-Score:-7.15|P-value:4.02E-13 ID:SGTC_2786|Compound:7743617|FD-Score:-4.34|P-value:7.05E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.08|P-value:1.98E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.14|P-value:8.51E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.53|P-value:2.90E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.74|P-value:9.39E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.28|P-value:4.73E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.26|P-value:4.92E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.93|P-value:3.77E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.36|P-value:3.51E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.09|P-value:9.08E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:-3.35|P-value:4.06E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.43|P-value:3.05E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.72|P-value:8.59E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.23|P-value:5.65E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.20|P-value:6.96E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.26|P-value:5.77E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.16|P-value:7.21E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.15|P-value:8.25E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.12|P-value:8.05E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.04|P-value:2.30E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.43|P-value:2.67E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.17|P-value:1.30E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.38|P-value:3.18E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.43|P-value:2.73E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.14|P-value:7.52E-4 ID:SGTC_1807|Compound:st050092|FD-Score:-3.44|P-value:2.93E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-3.97|P-value:3.69E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.18|P-value:1.24E-5 ID:SGTC_1825|Compound:st052143|FD-Score:3.41|P-value:2.88E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.61|P-value:1.36E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.59|P-value:1.66E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.40|P-value:2.96E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.47|P-value:2.32E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-4.26|P-value:1.03E-5 ID:SGTC_2426|Compound:5582046|FD-Score:7.88|P-value:1.09E-15 ID:SGTC_2429|Compound:5902844|FD-Score:-7.15|P-value:4.02E-13 ID:SGTC_2786|Compound:7743617|FD-Score:-4.34|P-value:7.05E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.08|P-value:1.98E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.14|P-value:8.51E-4

Top fitness defect scores for YMR155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2426 5582046 7.88 32.2 µM 1.09E-15 2 1.61E-15
2 SGTC_1823 3-hydroxy-2-naphthoic acid 4.18 106.0 µM 1.24E-5 10 1.44E-5
3 SGTC_1521 st012942 4.17 49.4 µM 1.30E-5 26 1.52E-5
4 SGTC_2789 5281112 4.08 71.4 µM 1.98E-5 33 2.29E-5
5 SGTC_1194 1488-0194 4.04 225.0 µM 2.30E-5 27 2.66E-5
6 SGTC_125 0133-0007 3.93 11.8 µM 3.77E-5 DNA intercalators 8 4.33E-5
7 SGTC_415 dibenzyl ketone 3.72 100.0 µM 8.59E-5 14 9.78E-5
8 SGTC_1832 st054113 3.69 55.0 µM 1.01E-4 8 1.14E-4
9 SGTC_1094 duloxetine 3.63 25.4 µM 1.25E-4 RPP1 & pyrimidine depletion 25 1.41E-4
10 SGTC_1894 3',6'-dihydroxyflavone 3.61 78.7 µM 1.36E-4 19 1.55E-4
11 SGTC_1948 st076329 3.47 66.6 µM 2.32E-4 45 2.62E-4
12 SGTC_217 ketoconazole 3.46 989.0 nM 2.42E-4 ergosterol depletion effects on membrane 42 2.72E-4
13 SGTC_1520 flindersine 3.43 88.0 µM 2.67E-4 46 3.00E-4
14 SGTC_1781 st038725 3.43 66.3 µM 2.73E-4 NEO1 129 3.06E-4
15 SGTC_1825 st052143 3.41 62.6 µM 2.88E-4 26 3.23E-4
16 SGTC_1932 st074806 3.40 40.9 µM 2.96E-4 47 3.32E-4
17 SGTC_1729 st035615 3.38 46.0 µM 3.18E-4 56 3.57E-4
18 SGTC_285 1486-1325 3.36 46.0 µM 3.51E-4 33 3.93E-4
19 SGTC_250 brefeldin a 3.31 552.2 µM 4.15E-4 PDR1 32 4.64E-4
20 SGTC_1315 1237-0019 3.29 3.7 µM 4.50E-4 24 5.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.15E-14 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.114 3.80E-11 YLR108C YLR108C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication
0.105 1.26E-9 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.103 2.42E-9 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.100 6.95E-9 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.091 1.43E-7 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.091 1.47E-7 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.090 1.71E-7 YDR219C MFB1 hom Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
0.084 1.23E-6 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.081 2.97E-6 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.080 3.86E-6 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.079 4.10E-6 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.079 4.27E-6 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
0.079 4.73E-6 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.079 5.09E-6 YDL187C_d YDL187C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data